Cancer

“And what we showed at ASCO and we published from a phase two study, but we believe it's the same thing in the phase three, because it's mechanistic, is that around 99 zero percent of the antigen are different patient to patient.”

“The two leading causes of death though, are cardiovascular disease and cancer is not metastasized to the brain. And I think both of those are going to be really attackable through this type of work.”

“Till the 19 seventies, I think in all of South India, there was like three recorded cases of cancer.”

“Look, I think that we have a chance for our children or the next generation, not only to not die from cancer, but to not know anybody who died from cancer. I think that is a real achievable goal in 25 years.”

“There's a shot that our children, none of them, nor their people they love will die of cancer.”

“We're literally, in our lifetime, we're going to have flying cars. We're going to have room temperature superconductors. We are going to solve cancer.”

“Well, look, I want to literally cure cancer. I know people said that's the cliche, but I actually, what we're building isomorphic is general purpose. So we're trying to build a platform, a drug design platform that will be applicable to any therapeutic area. S…”

“One year into the company, it is actually laid out that, you know, we would start at prenatal genetics, then go into late stage cancers, and then go into early stage cancers in this way.”

“I think it would be helpful for the industry to refocus some messaging on not AI is going to cure cancer, but human humanity is going to use AI to cure cancer and do a number of other things. Right. And so the bar is not just like one shotting it with a prompt…”

“One of the latest things in cancer research, which was interesting, there is a Microinflammatory environment that cancer cells need to thrive. They don't need oxygen. They like a low oxygen environment and they like an inflammatory environment. And so they're …”

“I mean, the most, what I think is like the highest odds is that Our kids, maybe our grandkids will live in an era which being diagnosed with cancer is not, not that big a deal.”

“I do believe all this amazing AI technology is people, I think people's lifespans are going to increase exponentially. Not until like 200 years, but we're not going to be living to 75, but we're going to be more commonly living to a hundred or a 105. There'll …”

“The DeepMind researchers in collaboration with Yale released a twenty seven billion parameter foundational model for single cell analysis. I'm not even going to try to name it. It's called C to S scale in shorthand. It's built on Google's open source gamma fam…”

“It's well known, and it's been often repeated, that medical error is a third leading cause of death in the United States after heart disease and cancer.”

“Until we've solved cancer, every month that we're not rushing to the frontier of accelerating biological discovery or scientific progress is a month that millions of people are suffering from disease that we could be solving with the eye.”

“So I think it would be twenty-twenty-eight if you're talking about automating a job at the average engineer, and then twenty-thirty-eight if we're talking about curing cancer.”

“But the reality is, if you cure all cancer, you extend American's lifespan by three years.”

“It takes 20 years to get these diseases, with rare exception. You know, heart disease, almost all cancers, and neurodegenerative, they are incubating for a very long time.”

“And cancer and neurodegenerative, just from what we know today with lifestyle factors, we're about half that can be prevented.”

“And so, you know, whether it's antibody drug conjugates, a tumor infiltrating lymphocytes, and all these different ways, it's hard to imagine that in the future, we're gonna lose people with cancer, Because of being able to bring your immune system to the high…”

“We only pick up 14% of cancers from that mass screening, which costs over hundreds of billions of dollars a year.”

“Heart attacks are the number one cause of death. They're the number one cause of death in men and women. Cardiovascular disease deaths are the number one cause of death and total 40% more deaths than all cancers combined.”

“Manus is kind of a new AI-driven drug discovery company. Targeting primarily cancer that says, we have this AI revolution, which creates these enormously new, better cognitive artifacts, and how can we deploy that in various ways to get drug discovery superpow…”

“Because obesity is a standalone risk factor for multiple types of cancer.”

“I think a hot take would be cancer is probably gone in 10 years, I think is one of my favorite hot takes. There's just so many different attacks on it, and CAR T cell therapies are doing well, and it's a matter of kind of scaling, scaling those out.”

“It turns out that people live to older age so much more now that they live long enough to get cancer.”

“And now there's the thing called the Grail test. It's not covered By all insurance in the US, so probably not by much in India, but if you can afford it, ah, that is almost magical at helping to see cancers way before other techniques would catch those.”

“Early detection is really what makes the difference. But the problem is you can't find cancer early in most organs in the body.”

“When we think about disease, we think of disease as something bad happening to us, but a lot of that stuff is exacerbated with age, and that age itself is like so much of the challenge that we get Cancer and Alzheimer's and type two diabetes with such greater …”

“4000 people die every day of heart disease and cancer, and no one says a word.”

“And that's why the vast majority of the cancer that we catch is actually stage one or localized to the organ of origin.”

“We just had cancer aneurysms in maybe one in 20 to one in 25 people, depending on the location.”

“The single biggest category are people that might've had cancer and worried that it's Coming back, or they have a strong family history of cancer, aneurysm, or disease, and for them, not being screened is obviously affecting their quality of life.”

“We want to detect cancer by using some of these technologies.”

“When we understand the immune system better and better, and we map more areas of the immune system, we will be able to cope with more rare autoimmune indications, orphan disease, and other you know, cancer indications that only few patients have.”

“And the interesting thing is that when we do our immune profiling of patients pre and post therapies, we see that some very subtle nuanced differences between responders and non-responders explain, or at least partially explain the reason. So we can find that …”

“Truly reset the age of the body and diseases of aging, like Alzheimer's and heart disease, even cancer will go away if we become young again.”

“The frontiers in RNA over the next decade could change the course of how we treat disease and change the course of outcomes for many diseases from genetic diseases all the way through to cancers.”

“Perhaps the pandemic was the accelerant we needed to get more of these to market faster and millions of people whose lives would have been lost or would be lost otherwise to cancer and other genetic diseases and so on over the years to come will be saved becau…”

“If I lose my hair, I'm going to look sick. If I look sick, I'm going to feel sick. Plus you lose your privacy of people constantly looking at you like, oh, do you have cancer?”

“We were both investors in Garden Health, which, you know, we might revolutionize how cancer is detected and how early it is. It might become part of our, you know, annual screening is just to get a blood test.”

“It's going to be tried in patients over the next year or so. If we were right scientifically, I think we can be thinking about seeing the beginning of the end of cancer.”

“I didn't feel like I could do that with the team. I felt like that team didn't know that I had cancer. They found out earlier this year when I told them before the blog post. But they, the board knew that I had cancer and they let me just be myself.”

“It's a technology that we have developed and can be used for several other types of cancers because all other types of cancers or many, many Of those also depict a similar thermal signature that we can find too. So not just for cancer as well, this can be used…”

“Cancer is the second leading cause of death, responsible for nearly ten million deaths globally every year.”

“I believe the missing link is extra chromosomal DNA or ECDNA, which represents a brand new way in understanding how cancer behaves.”

“This is what gives me hope that we will be able to one day erase cancer.”

“One thing that's interesting to think about is that you can think of DNA almost like a one-dimensional image, and so you can use the exact same technology now to put in DNA sequences, and maybe now you're not identifying a face, you're identifying whether some…”

“And if you correlate cancer with aging, the dogs after the age of even five, the probability of cancer goes way up.”

“40% of Americans will get cancer, and that number is only going to go up.”

“The economists have calculated that just reducing one major disease, let's say cancer, by just 10%, The U.S. Would save about three, four trillion dollars in the long run.”

“This is where AI could really be a part of the key missing link towards the cure to cancer.”

“The best drugs that we have today to treat cancer called immunotherapies only give you about 30 to 40% chance of five-year survival in treatment. These are the best drugs that we have. Chemotherapy and radiation give you less than 20%. Chance of survival. On t…”

“With that in mind, I think a lot of us like to think that it's going to be the next greatest drug that's going to cure cancer. It's going to be that, you know, silver bullet. There isn't really going to be a silver bullet in my mind to treating a hundred diffe…”

“There is some really tantalizing possibilities here that 80% of all cancers could be cured with existing drugs if we caught them early enough and we knew to give them early enough”

“Now, these are fundamentally very different diseases, different symptoms, different progressions, but they share the same underlying driving risk factor, which is how old you are.”

“And scientists have estimated that if we could cure all cancer, that would only get her up to 85. That would add only four years to the average lifespan.”

“So metformin is a first-line therapy for diabetes. Millions of people have been taking it for decades, and there was a paper that came out a few years ago where they looked retrospectively and saw that, hey, those diabetics that were taking metformin for decad…”

“In the case of cancer, it's unfortunate that 40% of the men and women in this room will likely be diagnosed with a form of cancer somewhere in their lives, sometime in their lives.”

“Part of what people don't necessarily always understand is that the practice of medicine is, is an art. Like, you can go, the reason why you can go to five different physicians and get five different ways of you know, treating cancer is because there's the pra…”