Knowledge Work

topic on 20 shows · 49 statements across 40 episodes

the Y Combinator Startup Podcast Mixergy BG2 Pod Innovators & Investors We Live to Build the Knowledge Project Latent Space Lenny's Podcast My First Million the Neon Show No Priors Invest Like the Best A Product Market Fit Show Sourcery Capital Allocators the MAD Podcast the a16z Podcast Big Technology All-In 20VC

49 statements about Knowledge Work, every show

a16z Insight
George: AI diffusion beyond coding will be slow because tasks lack verifiability
“Coding hit, but that's kind of a head fake, right? Like coding, coding is perfectly documented, right? So it has like perfect data. It's verifiable and it's simulatable, right? And so like most tasks in business do not share those three attributes. And so, you…”
David George Sep 10, 2026 ▶ 35:21 Why Investors Are Rethinking Everything for the AI Era
Seshan: AI products have entered a second era defined by agents
“The second era of these products is clearly working with agents and, you know, primarily has been coding agents. We'd like to bring it to more, more domains, certainly like knowledge work.”
Tara Seshan Aug 30, 2026 ▶ 34:57 AI’s third era: the rise of persistent AI coworkers | Tara Seshan (OpenAI’s product lead)
Seshan: Coding AI allows output verification; knowledge work requires process auditing
“Coding is so output oriented that when you ask it to do a coding task, you can verify whether it did the task correctly or well via tests. You can try it out and see if it works. Like there is a way to validate it based on the output. But knowledge work is dif…”
Tara Seshan Aug 30, 2026 ▶ 1:05:18 AI’s third era: the rise of persistent AI coworkers | Tara Seshan (OpenAI’s product lead)
Seshan: Knowledge work AI requires showing intermediate citations and in-progress work
“A lot of work that we have done and have to continue to do is continue to adapt the product to knowledge work, which means way more focus on Making ChatGPT your collaborator, allowing you to see all the in-progress work, see its citations and inputs, help you …”
Tara Seshan Aug 30, 2026 ▶ 1:05:53 AI’s third era: the rise of persistent AI coworkers | Tara Seshan (OpenAI’s product lead)
SOURCERY Opinion
Wu: AI will be capable of performing all pure human knowledge work
“I've always felt that there's, in terms of just pure knowledge work, there's, there is nothing that humans do that AIs can't do, you know, partly because Humans are, humans, you know, our brains are just computers, you know, like the AIs are too, right?”
Scott Wu Jul 27, 2026 ▶ 23:55 Inside the Fastest-Growing Category in AI: Scott Wu, CEO of $26B Cognition · Sourcery with Molly O'Shea
Kant: Solving knowledge work does not require 2-3 orders of magnitude scaling
“I'm no longer thinking that we need two or three orders of magnitude on the largest models to be able to You know, solve knowledge work the accounting, the legal, the code that we write.”
Eiso Kant Jul 22, 2026 ▶ 43:22 The AI Frontier: from open weights to open research — Eiso Kant, Poolside AI
NEON SHOW Insight
Siddharth: Humans Should Never Create V1 of Knowledge Work
“Basically the agents create V-one of the work. Humans are verifying and iterating. Humans never create V-one.”
Jonathan Siddharth Jun 18, 2026 ▶ 38:05 Why Coding is the Fastest Path to AGI | Turing CEO Jonathan Siddharth
20VC Insight
Foody: All knowledge work is converging on training AI agents
“All knowledge work is converging on training agents because it is structurally more efficient to do something once.”
Brendan Foody Jun 1, 2026 ▶ 15:40 Mercor CEO: Why Application Layer Companies Have No Moat & The Cost of Hiring AI Researchers · 20VC with Harry Stebbings
Rao: Enterprise AI frontier is long-horizon virtual collaborators with organizational context
“I think it is towards this vision or this goal of like a virtual collaborator. And so think of this as, you know, something that has context within your organization that can use all of the tools That are specific to you, whether they be homegrown tools or too…”
Krishna Rao May 13, 2026 ▶ 1:08:44 Inside Anthropic's $100 Billion Al Compute Commitment | CFO Krishna Rao · Invest Like The Best
KNOWLEDGE PROJECT Prediction Not checkable as stated
Weinberg predicts marginally faster attorneys will capture winner-take-all market dynamics
“And I think that that's what's gonna end up happening in knowledge work, where, you know, if an attorney is, is slightly better or slightly faster, they're gonna get all the work.”
Winston Weinberg May 12, 2026 ▶ 39:04 Speed, Stress, and Better Decisions | Winston Weinberg
AI knowledge work disruption parallels 2000s-era manufacturing automation and offshoring
“To me, it's still not significantly different than manufacturing automation in the 2000 and what that did to blue collar work in the U S and also outsourcing within China. And this is a whole other discussion right now. We only got two minutes left, but to me,…”
Ranjan Roy May 11, 2026 ▶ 54:11 The Unlikely Anthropic & SpaceX Marriage, OpenAI Trial Revelations, AI Layoffs Or Cope?
Y COMBINATOR Prediction Not checkable as stated
Garry Tan: Tokenmaxxing will permeate all knowledge work across society
“I think now it's going to permeate every part of society. Like, every thing that we would call knowledge work could be token maxed.”
Garry Tan May 8, 2026 ▶ 8:38 Tokenmaxxing: How Top Builders Use AI To Do The Work Of 400 Engineers · Y Combinator
LENNY'S PODCAST Prediction Not checkable as stated
Schoening: AI for Knowledge Work Will Reach 'Good Enough' Intelligence
“I think for a lot of knowledge work tasks, probably sometime we'll get to good enough. And once you get to good enough, then you can optimize other things. Like they run locally, they're cheaper, they're faster.”
Max Schoening May 2, 2026 ▶ 33:40 AI era skills: Why cultivating agency matters more than job titles | Max Schoening (Notion)
Schoening: Modern knowledge work effectively functions as universal basic income
“My take is that we already have universal basic income. It's called knowledge work. And I don't exclude my job from it, but if you really look about at what do we actually need to live and like to be content, it is a lot less than we've built this hierarchy. A…”
Max Schoening May 2, 2026 ▶ 1:08:00 AI era skills: Why cultivating agency matters more than job titles | Max Schoening (Notion)
MAD Assertion Not checkable as stated
Rieseberg: AI models can execute week-long knowledge work tasks today
“The models we have today are actually quite capable. They're quite capable of running knowledge work of both of an extremely long time horizon, the kind of things that you give to someone and expect like a week later.”
Felix Rieseberg Apr 10, 2026 ▶ 10:06 Anthropic’s Felix Rieseberg: Claude Cowork, Mythos, and the SaaS Extinction
a16z Prediction Not checkable as stated
Yang: Coding Will Eat All Knowledge Work
“I feel like coding will eat all knowledge work.”
Peter Yang Apr 6, 2026 ▶ 15:22 OpenClaw, Claude Code, and the Future of Software | Peter Yang on The a16z Show
Brockman: AI Progress Now Requires Real-World Feedback Over Benchmark Testing
“And that we're moving out of testing on benchmarks and sort of these almost cerebral demonstrations of capability to it actually being the case that for us to develop it further, we need to see it in the real world and get feedback from how people are using it…”
Greg Brockman Apr 1, 2026 ▶ 2:14 OpenAI President Greg Brockman: AI Self-Improvement, The Superapp Bet, Path To AGI, Scaling Compute
BIG TECHNOLOGY Prediction Not checkable as stated
Brockman: AI knowledge work will see a real takeoff within the next year
“We're going to see this real takeoff Of this technology and knowledge work over the next year.”
Greg Brockman Apr 1, 2026 ▶ 5:11 OpenAI President Greg Brockman: AI Self-Improvement, The Superapp Bet, Path To AGI, Scaling Compute
LATENT SPACE Prediction Not checkable as stated
Swyx: The major AI story of 2026 will be knowledge work agents
“I do think like a lot of the last year's, 20, 25 story was the rise of coding agents. And I think 26 stories, definitely knowledge work.”
Shawn Wang Mar 5, 2026 ▶ 28:55 Why Every Agent Needs a Box — Aaron Levie, Box
ALL-IN Prediction Not checkable as stated
Friedberg: Knowledge work may be a transitory phenomenon before AI
“It may be the case that knowledge work in general is also a transitory phenomenon that only existed between the foundation of the computer or computing tools and the existence of AI, generally speaking.”
David Friedberg Feb 28, 2026 ▶ 16:36 Software Stocks Implode, Claude's Hit List, State of the Union Reactions, Trump's Tariff Pivot
BIG TECHNOLOGY Prediction Not checkable as stated
Roy: AI will automate multi-step knowledge work across different systems
“In any kind of knowledge work, any multi-step process, like anything that can call from different systems, write to those systems, come up with some analysis and insight, so much of that work is going to be done.”
Ranjan Roy Feb 16, 2026 ▶ 3:45 Is Something Big Happening?, AI Safety Apocalypse, Anthropic Raises $30 Billion
BIG TECHNOLOGY Prediction Not checkable as stated
AI agents will disrupt general knowledge work by late 2026
“Yeah, that I'm telling you, I, that was my, in December, that was my prediction for 20, 26 on this show that what happened in software development is going to happen in knowledge worth this year. End of this year. It's happening.”
Ranjan Roy Feb 9, 2026 ▶ 29:08 Software In Shambles, OpenAI vs. Anthropic Super Brawl, Amazon’s Struggles
20VC Prediction Not checkable as stated
Lovinsky: Continuous background AI inference won't reach general knowledge work by 2026
“Whether it happens widely in knowledge work, By 20, 26, I think is, you know, I'll take a bet with you on that. Certainly for coding. I think in a lot of places we're already there, right? I mean, you have like the Ralph Wiggum stuff that, that popped up over,…”
Noam Lovinsky Jan 16, 2026 ▶ 32:35 20Product: Is the Design Phase Dead in a World of AI | Has Claude Code Crushed Anthropic Already | What Roles of a PM Are Less and More Important with AI | How the Best Product Leaders Tell Stories with Noam Lovinsky, CPO @ Superhuman
Monk: TPA shifts the institutional unit of work to knowledge analysis
“The unit of work becomes knowledge work instead of deal work. The unit of work is different. It's not capital deployment. It's not bucket filling. It's something else moving you towards your objective, intelligent understanding of additionality in your portfol…”
Ashby Monk Jan 12, 2026 ▶ 16:28 Ashby Monk – Total Portfolio Approach and the Future of Asset Owners (EP.480)
a16z Assertion Not checkable as stated
Acharya: People use AI code editor Cursor for writing essays
“I'm hearing increasingly about people doing knowledge work and writing essays in cursor instead of just writing code.”
Anish Acharya Dec 29, 2025 ▶ 41:28 Where does consumer AI stand at the end of 2025?
Smith: The 9-to-5 knowledge work structure is a massive waste
“And the way that nine to five knowledge work is structured is like one of the biggest freaking wastes in the world, in my opinion.”
Jennifer Smith Dec 8, 2025 ▶ 18:10 Her VCs said she killed the company. 6 years later, it's worth $1.3B. | Jennifer Smith, Founder o... · PMF Show
WE LIVE TO BUILD Prediction Not checkable as stated
Ustinov: Future Knowledge Work Will Center on Unified Context Over Apps
“And I strongly believe that in the future, most of the work with any kind of systems will look like this. Of course it wouldn't be a cursor. It would be like something nicer in terms of interface and everything. But the process of building up your context, bri…”
Seva Ustinov Nov 18, 2025 ▶ 37:24 He Manages $100M in Ad Spend With a Trick Nobody Tried Yet
MAD Prediction Not checkable as stated
Kant: AI is on track to rewrite $29T of global knowledge work
“I don't think anyone has any doubts anymore that we're now on track to reach human level capabilities and intelligence. And in that world, 29 trillion dollars of knowledge work rewrites itself, right?”
Eiso Kant Nov 6, 2025 ▶ 8:03 Intelligence Isn’t Enough: Why Energy & Compute Decide the AGI Race – Eiso Kant
MAD Prediction Not checkable as stated
Kant: AI models will equal top human knowledge workers within 36 months
“I think we have a hard time holding the point of view that models will reach the same level of intelligence and capabilities that the world's most capable people in every field have. And when you take a step back, and don't take the next 12 month view, but jus…”
Eiso Kant Nov 6, 2025 ▶ 47:30 Intelligence Isn’t Enough: Why Energy & Compute Decide the AGI Race – Eiso Kant
MAD Disclosure
Kant: Poolside aims to power all knowledge work globally
“And so we're starting to open up much more broader outside of software development and come back to what we've always said, like we want to be able to power all of knowledge work in the world.”
Eiso Kant Nov 6, 2025 ▶ 55:07 Intelligence Isn’t Enough: Why Energy & Compute Decide the AGI Race – Eiso Kant
MIXERGY Opinion
Lieberman: Engineers are seeing greater AI leverage than any other knowledge workers
“And one of the things I've realized working around engineers now is engineers are living in the future. Like they are seeing the greatest leverage of AI relative to all areas of knowledge work.”
Alex Lieberman Nov 5, 2025 ▶ 3:15 #2284 Why is Morning Brew’s founder selling “AI Transformation”?
MIXERGY Insight
Shipper: Driving is easier to automate than knowledge work because roads are static
“The difference is that the roads, even though things are complex and dynamic and all that kind of stuff on the road, the roads are the same. Like that's the same roads. You're getting from point A to point B and the way that that works, like you, there's a zil…”
Dan Shipper Oct 30, 2025 ▶ 43:27 #2283 How Dan Shipper uses AI to build artisanal AI apps
SOURCERY Prediction Not checkable as stated
Siddharth: AI will automate $30 trillion of global knowledge work
“This is like, if you look at those four dimensional, if you look at that four dimensional matrix, that's 30 trillion dollars of knowledge work that is going to be automated.”
Jonathan Siddharth Oct 10, 2025 ▶ 7:43 Inside The $2.2B AI Research Accelerator | Turing · Sourcery with Molly O'Shea
Krieger: Knowledge work AI progress follows code's exponential curve on a delay
“And I think of knowledge work as being on a similar sort of exponential as code has been on, but just time shifted, right?”
Mike Krieger Sep 30, 2025 ▶ 19:50 ⚡️Claude Sonnet 4.5 and Anthropic's roadmap for Agents and Developers — Mike Krieger, Anthropic
Levie: AI brings scalable automation to knowledge work tuned by compute
“For the first time ever with AI, we can bring automation to effectively all of that work. And that automation can kind of be tuned based on just how much compute we throw at the problem.”
Aaron Levie Sep 18, 2025 ▶ 41:33 Are 95% of Businesses Really Getting No Return on AI Investment? — With Aaron Levie
20VC Prediction Not checkable as stated
Osika: AI will devalue knowledge work just as fine art lost profitability
“I think we're going to have, like, Maybe a shift away from some very glamorous jobs, which people will be get depressed by, like similarly to how being like an artist was like so fucking cool, but clearly you can't make any money as an artist. I think we're go…”
Anton Osika Aug 18, 2025 ▶ 1:11:16 Lovable CEO, Anton Osika: The State of Foundation Models, Grok vs OpenAI, and Replit vs Bolt · 20VC with Harry Stebbings
Alalu: Human friction is a feature, not a bug, in some work
“While we see that there is a lot of opportunity to automate some types of knowledge related work, there's other places where human friction It's more of a feature than it is a bug.”
Joe Alalu Jul 28, 2025 ▶ 1:46 Diamonds in the Rough: Investing Where Grit Meets Innovation
20VC Prediction Open · timeframe Apr 2035
Lazarte: Only 1% of computer knowledge work will exist in 10 years
“What percentage of knowledge work as we know today will exist in 10 years? Like if you define work, knowledge work as work you do behind a computer, I think it's probably like one percent.”
Victor Lazarte Apr 14, 2025 ▶ 38:50 Benchmark GP, Victor Lazarte: The 3 Traits All the Best Founders Have · 20VC with Harry Stebbings
NO PRIORS Insight
Foody: Agent eval creation is biggest barrier to automating knowledge work
“And so I think we're going to see an immense amount of eval creation for, like, agents and that is the largest barrier to Automating most knowledge work in the economy.”
Brendan Foody Apr 10, 2025 ▶ 15:11 No Priors Ep. 110 | With Mercor CEO and Co-Founder Brendan Foody
NO PRIORS Prediction Not checkable as stated
Foody: Eval creation could become the most common knowledge job globally
“It Would not surprise me if that becomes the most common knowledge work job in the world.”
Brendan Foody Apr 10, 2025 ▶ 19:43 No Priors Ep. 110 | With Mercor CEO and Co-Founder Brendan Foody
Houston: Decoupling work from location is knowledge work's biggest shift since 1959
“This idea of our, we're finally decoupling work from the physical, our physical location. It's a big deal. It's probably one of the biggest changes to knowledge work in our lifetimes, or even since Drucker coined that term knowledge work in 1959.”
Drew Houston Jan 9, 2025 ▶ 1:07:24 Behind the founder: Drew Houston (Dropbox)
BG2 Insight
Levie: AI succeeds in coding because code is linear and open-source
“Coding is still working better than most other use cases. And it's because you basically have a workflow where you're in a text interface that is just linear, where most of the sort of knowledge of that, of the field is all public and open source for the most …”
Aaron Levie Feb 8, 2024 ▶ 1:05:23 BG2 with Bill Gurley, Brad Gerstner & Aaron Levie | Software Valuations, Earnings, Immigration | E02 · Bg2 Pod
BG2 Prediction Not checkable as stated
Levie: Expecting GitHub Copilot-level gains across general knowledge work is premature
“So this idea that, that you're going to get a, you're going to get a GitHub co-pilot effect for all forms of knowledge work, at least in the near term, it's way too early to be kind of jumping to that.”
Aaron Levie Feb 8, 2024 ▶ 1:06:01 BG2 with Bill Gurley, Brad Gerstner & Aaron Levie | Software Valuations, Earnings, Immigration | E02 · Bg2 Pod
a16z Opinion
Smartphones did not significantly boost knowledge worker productivity
“I don't think the smartphone helped much at all just in terms of productivity and knowledge work.”
Kevin Scott Sep 25, 2023 ▶ 7:31 AI Copilots and the Future of Knowledge Work with Microsoft's Kevin Scott
ALL-IN Prediction Not checkable as stated
Chamath: Physical labor will get more expensive while AI deflates knowledge work
“Physical labor will continue to be more expensive. They'll demand more and more money to do the job that they're asked to do. And then knowledge work will become increasingly more deflationary because so much of it will be automated by AI that those folks will…”
Chamath Palihapitiya Apr 28, 2023 ▶ 23:58 E126: Big Tech blow-out, Powell’s recession warning, lab-grown meat, RFK Jr shakes up race & more
ALL-IN Prediction Not checkable as stated
Calacanis: Knowledge work will cost 90% less within 5 to 10 quarters
“All this knowledge work is going to be 10% as expensive to do. I don't think it's 10% less Chamath or the, you know, I think it's like 90%, 10 cents on the dollar. And it's not, this is not a five year, 10 year prediction. This is like five quarter, 10 quarter…”
Jason Calacanis Apr 28, 2023 ▶ 32:31 E126: Big Tech blow-out, Powell’s recession warning, lab-grown meat, RFK Jr shakes up race & more
Shaan Puri: The 40-hour workweek makes no sense for knowledge workers
“If you're working with your brain you're doing knowledge work, that work week doesn't make any sense.”
Shaan Puri Aug 24, 2021 ▶ 1:50 Why You Shouldn't Be A Slave to a 40 Hour Work Week | My First Million #212
20VC Insight
AI productivity gains require reorganizing work around human leverage
“To my own horn, as I was trying to push years ago, and we still push you know, the real model, I think, is you have to think about AI and people as symbiotic, and you have to think about the real transition in the industrial revolution of knowledge work we're …”
Sam Lessin Feb 4, 2019 ▶ 8:19 20VC: Slow Ventures' Sam Lessin on How VC Forces Certain Companies To Exist and Makes It Difficult To Finance Others, Why Cities Won't Let Scooter Companies Be Profitable and Why Dapps Are A Concern and Where Emphasis Should Be Placed In Crypto
Benet: Crypto networks reward knowledge work better than salaried employment
“You can't measure knowledge work in hours. Somebody's investment over a decade can put them into the right perspective to make the right contribution at the right time, that creates something like Ethereum or Bitcoin or whatever. And, you know, how do you corr…”
Juan Benet Jul 1, 2017 ▶ 1:40:14 IPFS, CoinList, and the Filecoin ICO with Juan Benet and Dalton Caldwell · Y Combinator

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