Depression

“And then also some other things are also a bit more subtle when you look at the effect of an unhealthy gut on symptoms like anxiety, risk of depression, just an immune system that's out of check. Maybe influenced by some disturbances in the gut has an impact.”

“As a matter of fact, the best predictor of depression, anxiety, For young adults is the answer yes to the question. Does your life feel meaningless? That's the best predictor.”

“Depression has increased by about a factor of three for people under 30. Anxiety by about a factor of two.”

“60% of the people who use drugs or therapy to try and get out of depression, make zero improvements.”

“There's actually data to support that when you're having sex once a week, that those people live longer and have less depression than people that don't.”

“And I have talked to many founders who left their company, and there's like, I'd say half of them fall into a depression because their identity is the company.”

“The number one, however, significantly more than exercise and cognitive behavioral therapy, higher than yoga, higher than Tai Chi, was dancing. Dance therapy outperformed exercise significantly. Dance, According to this meta-analysis had the greatest impact in…”

“Like Prozac for instance. It was never studied long term for depression. It was studied to be implemented as a basically like an emergency shoot when you're going through a terrible time period. You use it during a window.”

“We would have ended up, if I didn't do that, we would have ended up in a depression.”

“I left my church, and I got a divorce. And those two changes just made it evaporate. So it was environmental, and it was contextual.”

“It was the people that had hope, but not expectations that did, right? So they knew they'd get out of there, but they didn't have an expectation on when. And I think depression is, is like that as well.”

“When people feel suicidal, I am deeply empathetic. It is rational to want to kill oneself. It's reasonable.”

“I would make sleep your number one life priority. Like the most important thing you do in any given day is high quality sleep. And I would build your life around it because when you have good sleep, So many of the things in life are much better, and then if yo…”

“I am very open with, I share my humanity all the time. You know, I'm medicated on for depression. They know that. I let them know that.”

“And that led to this disconnect between the inner me and the outer me, which on a prolonged period of time leads to depression.”

“That even if you could take away the depression or the trauma or give somebody, you know, the perfect life and everything they wanted, once they've developed the disease of addiction, they have addiction, and if you don't intervene for that problem, it's typic…”

“Because there's very clear and known research that has shown, you know, microdosing mushrooms can significantly help with or get rid of PTSD, stress, anxiety, depression.”

“We will, 100% basically be able to, you know, get rid of pain probably, you know, short circuit depression, like, all these sorts of things we will be able to do without needing to know exactly what, you know, we'll know the math, because you can look into thi…”

“There's tremendous amount of research that has proven without a shadow of a doubt that, that psychedelics have been amazing for curing depression. Curing depression. Curing treatment-resistant depression”

“National Institute of Mental Health says that 43% of us are now saying that we have a form of depression.”

“I personally now can pretty cleanly like tell the difference between exhaustion and depression and It tends to tie to my broader motivations, not just my motivation to work, right? So like, the, like, when I'm exhausted, I will, I'll still show up to work, I'l…”

“National statistics report that now, nowadays, over 40% of college students report being too depressed to function most days. Over 60% say that they're overwhelmingly anxious. Another over 60% report feeling lonely, extremely lonely most of the time. Over 80% …”

“And actually it's a hallmark physiological signature of depression to have a late shifted cortisol peak.”

“I've discovered as well that the people who I believe are depressed, even if they refuse to admit it to themselves, find that it's easier to live in the comfort of depression than to strive to do something that would make them happy, which would then bring the…”

“That sets A cortisol increase in the morning, which is a healthy cortisol increase that provides wakefulness, triggers your metabolism in the proper direction. If that cortisol spike happens too late because you didn't view light, then you step out during noon…”

“The key is that if they experience these traumas in an unpredictable way, with, like, you know, you don't know when it's gonna end, you don't know the next thing's gonna happen, that's when you actually get, you know, the symptoms of depression and giving up.”

“Cause I mean, I can tell you the one big breakthrough that we now know is that concussions make you incredibly depressed cause your brain is trying to stop you from getting injured again. And so it kind of shuts down all the pathways that Tell your brain it's …”

“My wife is a clinical psychologist who works with a lot of startup founders, and she often quotes a study that indicates entrepreneurs experience higher levels of stress and anxiety, while people with salary jobs experience higher levels of depression.”

“It translates into depression, anxiety, heart disease, diabetes. They're all metabolic illnesses that come from a debt, running a deficit in your body budget.”

“But the reality is most people struggle in one way or another. And most Founders actually do struggle with, whether it's depression, anxiety, ADD, and actually the flip side of that, which is pretty interesting, is sometimes it's part of what allows them to be…”

“At a much earlier age, perhaps, than you were prepared for, you were thrust into a position of being a parent, taking care, being a caregiver. And that's an important statement that you just made, because while it's not the only root cause of mental illnesses,…”

“I had my first major depressive episode when I was running my first company in my mid-twenties, and it was triggered by three things happening at the same time. The first was I ended up getting divorced from my first wife. Our relationship blew up. The second …”

“If the quarantine goes on for months as our only way of dealing with the virus, then, you know, we could be looking at the depression.”

“We can use selfies to predict skin cancer. We can use changes in your voice to predict depression or on early onset Alzheimer's.”

“Rates of depression and anxiety before puberty are fairly similar. But at puberty there's a big divergence and depression and anxiety generally go up for girls.”

“It turns out I have a propensity clinically for depression, and so I got to the place where I kind of had to fake it at work that I was doing ok, but drag myself out of bed and come to the office and kind of put on a show.”

“There's a lot of research showing agency affects it positively. So people who have a sense of agency, of control, they're less likely to be depressed. They're more likely to be healthy as well because the two are very much correlated. Our mental state affects,…”

“You know, as a short-term thing to get people through a crisis time, I think sometimes it can be really helpful, and for some people it works, but for a lot of people it's a short-term fix that doesn't really change the causes of the depression.”

“They'd had depression for an average of 18 years, and they tried between I think three and 11 types of antidepressants.”

“It seems to, for most people last for about two or three months and then the depression starts to come back.”

“If you just give someone a psychedelic and you don't encourage them to make the most of the window of opportunity, then what we found with our participants is that the depression came back after three months or so.”

“So the area of digital therapeutics lies in the fact that for many areas, such as type two diabetes, anxiety, depression, PTSD, I think our go-to for cures for this is a pill, but actually these are behavioral problems, and it's much more natural to have a beh…”

“To some extent, you know, our attitude in life, our mood, our happiness levels, depression levels, these are also habits.”

“Sometimes patients come and complain about pain, but what they really are talking about is depression. And if you had some context about where they're coming from, you would not look for the source of pain, you would look for why they're depressed.”