Moderna

“So indeed last week now we shared the news with our colleagues at Merck that after working 10 years on the individualized treatment against cancer using mRNA technology, that the phase three was positive.”

“It's the first time that there is an agent In melanoma that is better than Ketudra alone.”

“Here it's the first time there is a cancer vaccine working. The field, as you know, has been doing that for 20 plus years. I think more than a thousand clinical trials that have all failed.”

“What we announced last week is that we met the primary End point of a study, which was recurrence-free survival, i.e. People having the cancer back or dying, that we met, and then to our own surprise, because this was the first interim analysis. This is not th…”

“The factory is ready in Massachusetts, but we have figured out how to make and scale a product for every human being at the time.”

“With all technology, I cannot speak about all the mRNA companies that have different mRNAs, different lipids, and so on, but with all technology, when we inject our mRNA in a muscle, whether it's a COVID shot, a flu shot, or this cancer treatment, basically th…”

“We select the 34 that we believe are the most relevant, and we stitch them together into one big mRNA molecule, which we make in thirty-ish days for you, that is injected then in a hospital intramuscularly.”

“And what we showed at ASCO and we published from a phase two study, but we believe it's the same thing in the phase three, because it's mechanistic, is that around 99 zero percent of the antigen are different patient to patient.”

“Because the algorithm from the phase three was the same from the phase two, was the same from the phase one. But because we've been doing this for 10 years, it's a 10 year old algorithm.”

“As we said about the phase two data, 80% of people are disease-free after five years.”

“Well, it's exactly the same for Intismaran, which is the current version of Intismaran that Moderna is the worst version of Intismaran you're going to see for the rest of medical history.”

“So the time is around 42 days now, needle to needle. So from taking the biopsy to getting the vaccine in the hospital ready for you.”

“But now we don't make it with plasmid growing E. Coli or whatever. We make it all synthetic. So it's all enzymatic in liquid, in water.”

“The facility will be able to make the one in Marlboro, Mass, tens of thousands of doses.”

“As you mentioned, CAR-T, CAR-T was also approved in the same way as we believe Intesmiran will be, which is as a process BLA not a product BLA.”

“We showed it even at ASCO this year, where we took the blood before treatment, after treatment of cancer patients, melanoma, with all technology, and we showed that I don't think we have an expansion of the T-cells, But we have de novo, so new T cells being cr…”

“We announced in the spring of 2026, starting a phase three study for patients with stage one lung cancer, but as Intismarine, so Moderna's product, as a monotherapy without checkpoint.”

“I think they went from like a twenty billion market cap to sixty billion market cap on the positive readouts from this thing that's being called a cancer vaccine”

“And like, Moderna is like an IP company. It's like the same thing as publishing. The stock is going to go down. The innovations might be amazing. But unlike Lilly, like they don't have any angle other than publishing, which is not a good business. So the stock…”

“Like SpaceX is a meme. It's a great meme. It's an awesome meme. Like, SpaceX, like Moderna, has every ability to pop out headlines that people are going to go nuts for. But, you know, it isn't that dissimilar from a GME, not in that they don't do amazing thing…”

“So we have developed some monster UTRs, untranslated regions, which flank the protein coding region which dictate those expression properties. Something like Tenex, the references from Moderna and Pfizer. And over the course of six months, got to in vivo data …”

“Today we work with about 1300 biotech and pharma companies scientists at over 7000 academic institutions, universities, all, all around the world. And our software powers, you know, household names like Moderna and Sanofi and Eli Lilly and Regeneron, but also …”

“The last time a fifty billion dollar plus biotech company was started from scratch, excluding Moderna, which was kind of an accident of COVID, was in the eighties. I think it was Regeneron. And so it's been almost 40 years since we've had a de novo, like tens …”

“MRNA, which was our 18th company that became Moderna is a good example of this. There was no mRNA drug or vaccine before. There was nobody working on it. When we started, there were academic labs that had worked on it and given up.”

“So our mRNA vaccines from Moderna or Pfizer were gene therapies and they cost two bucks each, right? They were sold for 20 bucks or whatever the case might be. So we know that you can mass produce gene therapies extraordinarily cheaply.”

“It was only seven weeks, 63 days, between the sequencing of the DNA of the virus and the first human being that Moderna gave the vaccine to”

“And now we're talking about a modality that might end up before the end of the decade being the second or third biggest modality in terms of revenue and potentially also in terms of impact.”

“The last time a biotech company hit, I don't know what it is, 3040, fifty billion dollars in market cap, something like that. The last year such a thing was founded was in the late eighties. So it's been at this point, what is that? 35, 40 years without a new …”

“In the exact same year that we Did the foundation laying for what became Moderna. We also started four other projects that were each platforms in their own right, going after different aspects of biomedical opportunity space, each with as big a leap, each with…”

“We had tested nine, maybe even 10 different human vaccines in every single case showing neutralizing antibodies, and we had also another nine programs that were going after human therapeutics, so it was a fairly broad platform that had already been developed. …”

“Before a single vaccine for coronavirus that we tested, we had already 2000 people Who had received mRNA from us.”

“And to the time when we had the computer-generated sequence of the RNA, that is essentially today mRNA-twelve-seventy-three, was two days.”

“Well, we indeed, in May, we indeed did come out and say at a very high level that we had some encouraging results, and people attacked us every which way for having said that, because they basically said, well, that's doing science by press release and many ot…”

“We didn't do the clinical work. They did.”

“We could make, you know, a billion doses the first year of production, up from probably making, you know, a thousand doses the year before of anything.”

“In 2003, when the SARS outbreak broke, took us seven months to read the genome of the SARS. And you have to read the genome to create an effective vaccine. When COVID broke, it took us two days. That information was digitally sent to Moderna, and it took th…”

“Governments all around the world have said, look, if someone can come up with a vaccine for COVID-. We will buy You know, forty million doses, fifty million doses, whatever it is that has worked to produce a huge race among different companies, and the great t…”

“I think that the biggest winner in business this year is a company that started a few years ago called Moderna.”