Medicine

topic on 18 shows · 40 statements across 33 episodes

the Y Combinator Startup Podcast Cheeky Pint American Optimist the Knowledge Project Masters of Scale Latent Space No Priors WTF is with Nikhil Kamath Invest Like the Best A Product Market Fit Show Sourcery Capital Allocators the MAD Podcast the a16z Podcast Big Technology All-In TBPN 20VC

40 statements about Medicine, every show

NO PRIORS Insight
Hodak: Vision, hearing, balance, and 1 kbps motor control unlock radical neurotech
“If you can, if you get vision, hearing, balance, and a kilobit per second of motor control, you're halfway to the matrix. And this takes you into some like really trippy interpret reinterpretations of medicine.”
Max Hodak Aug 20, 2026 ▶ 14:06 From Restoring Sight to Reimagining the Brain, with Max Hodak
20VC Prediction Not checkable as stated
Angelopoulos: AI Will Eradicate Diseases Like Open Problems in Math
“I think that the, like, level of just human flourishing that's going to happen as we start to one by one eradicate diseases the same way that we're currently eradicating open problems in math is going to be incredible.”
Anastasios Angelopoulos Aug 2, 2026 ▶ 1:07:41 Arena CEO: There Will be a $100BN US Open-Source Model & Data is a Trillion Dollar Market
20VC Prediction Not checkable as stated
Angelopoulos: Value in AI Biology Will Accrue to Data Layer
“That's exactly one of the areas where the data layer, where you can clearly see that the data layer is where value is going to accrue. Because the GPUs Are the same GPUs in both cases. The problem is that, that data infrastructure, the flywheel, the data colle…”
Anastasios Angelopoulos Aug 2, 2026 ▶ 1:08:28 Arena CEO: There Will be a $100BN US Open-Source Model & Data is a Trillion Dollar Market
AMERICAN OPTIMIST Assertion Partly supported
Emil Michael: The United States Currently Has 250 Medicines in Shortage
“We have 250 medicines on shortage in the United States.”
Emil Michael Jul 24, 2026 ▶ 22:42 America’s $700 Billion Defense Tech Rebuild
ALL-IN Assertion Not checkable as stated
Mark Cuban asserts 95% of medicine is guessing
“Because 95% of medicine is guessing.”
Mark Cuban Jul 21, 2026 ▶ 23:51 Mark Cuban on the AI Bubble: Who Actually Gets Wiped Out?
TBPN Prediction Not checkable as stated
AI Enthusiasts Will Disrupt Medicine, Law, and Banking Sectors
“And I think AI maniacs will compete in medicine, law, business consulting, banking, wherever it is, we let them compete.”
Tyler Cowen Jul 20, 2026 ▶ 12:23 Tyler Cowen Doesn't Think America Should Ban Chinese AI Models
WTF Assertion Partly supported
Juneja: Up to 2% of all manufactured medicines expire before consumption
“Approximately, the 1.5 to two percent of medicines get expired.”
Rajiv Juneja Jun 17, 2026 ▶ 2:38:23 Two Pharma Giants Who'd Never Met | Mankind & Dr. Reddy's | WTF is Pharma? · Nikhil Kamath
Carnell: Scientists have already found medicines for most fatal diseases
“Is that incredible scientists have already cracked the code on most of the medicines we need to protect us from most of the diseases that will claim most of our lives.”
Alex Carnell Apr 21, 2026 ▶ 3:17 GLP-1s, Peptides, and The Trillion-Dollar Health Revolution · Invest Like The Best
White: Natural language is the only way to connect all scientific data
“And so I think that that, for that reason, natural language is the only possible way to connect all the different pieces of data we need in biology, medicine, or any domain for that matter.”
Andrew White Jan 28, 2026 ▶ 1:01:52 🔬 From Red Teaming GPT-4 to Automating Drug Discovery: The Future of AI in Science — Andrew White
Hoffman: Skipping an AI second opinion for medical issues is a mistake
“If you get a serious, you know, kind of medical concern, if you're not using one or more frontier agents as a second opinion, you're making a desperately bad mistake, right?”
Reid Hoffman Jan 24, 2026 ▶ 19:55 Reid Hoffman & Inflection AI CEO: Designing AI that makes us better humans (Sean White) | Summit '25
Hodak: Neural engineering produces therapeutic effect sizes unseen in conventional medicine
“One of the reasons that I like the neural engineering approach is it produces these very large effect sizes. Like, cochlear implants, really, if you are deaf due to sensorineural hearing loss, they really work. Or if you've ever seen a video of a Parkinson's p…”
Max Hodak Dec 12, 2025 ▶ 6:48 Can The Brain Merge With Artificial Intelligence? — With Max Hodak
CHEEKY PINT Assertion Supported
Ricks: There are roughly 2,000 approved synthetic medicines across 400 mechanisms
“We probably have 2000 manmade approved medicines versus natural products or vitamins or other things, and maybe 400 unique mechanisms.”
Dave Ricks Nov 11, 2025 ▶ 21:43 Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
CHEEKY PINT Assertion Supported
Ricks: Medicine accounts for only 10 cents of every US healthcare dollar
“In the US, the most expensive healthcare system in the world, we spend 10 cents on the dollar on medicine. The other 90 cents go through everything else that medicine's trying to prevent.”
Dave Ricks Nov 11, 2025 ▶ 34:06 Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
Y COMBINATOR Prediction Not checkable as stated
Tom Blomfield says ignoring AI will be a disadvantage within two years
“I'm not sure it's yet a competitive disadvantage, but I can imagine that becoming true in the next year or two as your tools get really, really good.”
Tom Blomfield May 9, 2025 ▶ 13:56 How AI Coding Agents Will Change Your Job · Y Combinator
Y COMBINATOR Prediction Not checkable as stated
Tom Blomfield says AI will transform law and medicine within five years
“So many industries like law or education or medicine that really were not big buyers of software in the past that are going to be transformed in the next five years.”
Tom Blomfield May 9, 2025 ▶ 18:46 How AI Coding Agents Will Change Your Job · Y Combinator
SOURCERY Insight
Peters: A doctor's core role is an informatics problem triangulating three databases
“Basically healthcare is, a doctor's job is an informatics problem, right? You're computing between, when you're a doctor and you go see a patient, you're computing between a database of what you know about a patient, what you know about medicine, and what inte…”
Jacob Peters Apr 22, 2025 ▶ 28:43 Superpower Raises $30M Series A Led by Forerunner · Sourcery with Molly O'Shea
SOURCERY Opinion
Peters: Foundation models eliminate compute constraints in medicine
“With the advancement of foundation models compute is no longer a constraint in medicine, which has opened up this market opportunity in this portal for healthcare to really be built as a product.”
Jacob Peters Apr 22, 2025 ▶ 29:41 Superpower Raises $30M Series A Led by Forerunner · Sourcery with Molly O'Shea
PRODUCT MARKET FIT Assertion Supported
Heart medications don't eliminate plaque; they transform it into stable protective plaque
“And what we found was that the medicines, they didn't make plaque go away per se. They just transformed that plaque from the good to the, from the bad to the good plaque over time, and that was the mechanism of stabilization.”
Dr. Jim Apr 14, 2025 ▶ 8:12 He raised $300M to prevent heart attacks. Here's how he got his health tech startup off the groun... · PMF Show
Medical practice takes 20 years to change because doctors must retire first
“And so it's just, and then they always say in medicine that things take about 20 years to change medicine. And if you think about it, that is about the time that it takes for one generation to retire and a new generation to come about. So, you know, once peopl…”
Dr. Jim Apr 14, 2025 ▶ 20:13 He raised $300M to prevent heart attacks. Here's how he got his health tech startup off the groun... · PMF Show
NO PRIORS Prediction Not checkable as stated
Weinberg: AI will produce specialized ChatGPT-level breakthroughs in coding and medicine
“I think we will end up seeing work completion done in very sophisticated manners, like in medicine and in coding, like a lot in coding and a lot also in, you know, other areas too, that will kind of bring us back to the chat GBT moment, but it will be speciali…”
Winston Weinberg Feb 14, 2025 ▶ 46:25 No Priors Ep. 101 | With Harvey CEO and Co-Founder Winston Weinberg
MASTERS OF SCALE Assertion Supported
Women were historically excluded from clinical trials until roughly 20 years ago
“Women, you know, women have been historically underserved by medicine because people weren't studying women's physiology with, you know, in clinical trials up until the last 20 years or so.”
Tom Hale Jan 9, 2025 ▶ 29:46 How Ōura doubled ring sales in two years (with CEO Tom Hale) | Masters of Scale
a16z Prediction Not checkable as stated
Pande: Medicine will transition from a human problem to a data problem
“I think we'll get to that point where medicine will be about incorporating all this data. Data about me as a patient, data about everyone else that's like me to be able to draw the best conclusions. That's something that is just a computer problem. And that mu…”
Vijay Pande Sep 5, 2024 ▶ 24:51 Implementation, Data, Impact of Healthcare AI with Julie and Vijay
Ravi: SAM impacts medicine more than I could have as a doctor
“Actually Sam is having so much impact in medicine, probably more than I could have ever had as a doctor myself.”
Nikhila Ravi Aug 7, 2024 ▶ 3:16 Segment Anything 2: Memory + Vision = Object Permanence — with Nikhila Ravi and Joseph Nelson
LATENT SPACE Assertion Supported
Howard: Enlitic was the first company to use deep learning in medicine
“Yeah, I was actually the first company to use deep learning in medicine, so I kind of founded the field.”
Jeremy Howard Oct 20, 2023 ▶ 3:28 The End of Finetuning — with Jeremy Howard of Fast.ai
MAD Prediction Not checkable as stated
Socher: Generating protein sequences with LLMs will transform medicine next decade
“They use large language models to generate new protein sequences. And I think that will change all of medicine in the next decade in a massive way.”
Richard Socher Aug 16, 2023 ▶ 33:10 Reinventing Search with AI: Richard Socher on Building You.com & the Future of Google
Attia: Medicine and science are distinct, and med school does not teach science
“I think people confuse medicine and science. They're actually not the same thing. And like, I didn't learn one shred of scientific thought in medical school.”
Dr. Peter Attia Apr 19, 2023 ▶ 32:01 Ep 54: Peter Attia, Ryan Holiday & Joe Lonsdale Discuss Longevity & America's Health · Joe Lonsdale
AMERICAN OPTIMIST Prediction Not checkable as stated
Attia: AI will impact medicine, but not within two years
“It's hard for me to imagine that AI will not play a meaningful impact in medicine. I don't think it will be on the time scale that People talk about it. I think people talk about it like, oh, we're just two years away from this.”
Dr. Peter Attia Apr 19, 2023 ▶ 33:29 Ep 54: Peter Attia, Ryan Holiday & Joe Lonsdale Discuss Longevity & America's Health · Joe Lonsdale
Attia: Medicine is falling behind tech and finance for top talent
“I would gather that there is a historical trend line that shows a waxing and waning of where the top talent go. Like where are the best and brightest out of college go? How many of them are going to Goldman Sachs? How many of them are starting, going to startu…”
Dr. Peter Attia Apr 19, 2023 ▶ 35:08 Ep 54: Peter Attia, Ryan Holiday & Joe Lonsdale Discuss Longevity & America's Health · Joe Lonsdale
High-status careers like finance appeal to ambitious students by replicating school
“Finance, consulting, law, medicine, those were the like easy ones. And they had a lot of the characteristics of school. Like there was a clear application process. There was a clear steps. These steps were kind of imposed upon you. Like the, it was a very comf…”
Michael Seibel Feb 5, 2023 ▶ 3:08 The Cult of Conformity in Silicon Valley · Y Combinator
CAPITAL ALLOCATORS Assertion Supported
Acker: Small and mid-cap biotechs develop over 60% of new medicines
“Over 60% of the new medicines that reach the market today were developed by small and mid cap biotech companies.”
Andy Acker Oct 6, 2022 ▶ 35:36 Andy Acker - Empty Rooms: Investing in Biotech at Janus Henderson (Capital Allocators, EP.274)
Gimenez: Cancer treatments should target molecular markers, not tissue origin
“There's nothing about our medicines, at least chemical medicines or biological or whatever medicines that are necessarily about the part of the body it's in besides distribution and delivery. But we're starting to rethink how we think about that and say like, …”
Dr. Francisco Gimenez Apr 18, 2022 ▶ 17:19 The Year That Changed Medicine Forever | Francisco Gimenez Explains the Biotech Revolution. · Joe Lonsdale
Klausner: Cellular Rejuvenation Would Be Humanity's Biggest Medical Revolution
“Cells are able to do that and the ability to imagine understanding and controlling that would be the biggest revolution in medicine, health, maybe even society that humanity has ever experienced.”
Dr. Rick Klausner Jun 29, 2021 ▶ 17:49 Dr. Rick Klausner: Curing Cancer, Reprogramming Cells, and the Incredible Biotech Revolution · Joe Lonsdale
ALL-IN Assertion Not checkable as stated
Friedberg: Medicine is on the verge of biological machine-based therapies
“We are actually on the precipice of creating machines, biologically engineered or designed cells, and proteins that can go into your body and do specific things and enhance your life and improve your health and solve, you know, disease.”
David Friedberg Feb 20, 2021 ▶ 1:19:02 E23: Radical DAs, breaking down FB/Google vs. Australia, sustained fear post-vaccine & fan questions
Vorster: Medicine has a firmer scientific foundation than finance and economics
“There was also perhaps a more accessible scientific base to medicine, whereas finance and economics are often based on theory and on retrospective type of analyses and long run averages and things like that.”
Dr. Charles (Sarel) Vorster Dec 23, 2019 ▶ 45:01 Dr. Sarel Vorster – Conducting Brain Surgery (Capital Allocators, EP.117)
a16z Assertion Supported
Chokshi: Novartis produces 70 billion doses of medicine annually
“In terms of volume, they're the largest producer of medicines, With seventy billion doses a year across a wide range of therapeutic areas from cancer to cardiovascular disease and more.”
Sonal Chokshi Jan 17, 2019 ▶ 0:26 a16z Podcast | The Science and Business of Innovative Medicines
a16z Opinion
Mike Snyder: Current medical practice is Byzantine and crude
“I think the way we do medicine now is totally Byzantine. It's just really ridiculous how crude we are at what we do.”
Mike Snyder Jan 2, 2019 ▶ 6:29 a16z Podcast | How to Live Longer and Better
a16z Assertion Not checkable as stated
Kaditz: Discarding raw medical data prevents the building of predictive models
“Like right now in medicine, a lot of times we store the result of a diagnostic, but we don't keep the measurement, which actually prohibits us from going back and building models that, you know, in reusing the measurement.”
Jeff Kaditz Jan 2, 2019 ▶ 14:17 a16z Podcast | Health Data -- A Feedback Loop for Humanity
a16z Assertion Not checkable as stated
Humans are increasingly able to program living things as medicine
“And specifically, I want to talk about our increasing ability to program living things to serve as medicines for us.”
Jorge Conde Dec 22, 2018 ▶ 0:31 Programming Medicine
Mr. Money Mustache: Formal Higher Education Is Unnecessary for Most Non-Traditional Careers
“Without schooling, formal schooling, you can probably do it better and learn it better yourself. It's only like the most traditional professions now, like medicine and other like certain types of law that require this really formal stuff.”
Mr. Money Mustache Sep 27, 2017 ▶ 44:44 Don't Start a Blog, Start a Cult - Mr. Money Mustache · Y Combinator
Domingos: Doctors Gatekeep Medical AI to Prevent Automating Their Own Jobs
“In the particular case of medicine, it's not used more already because, of course, the doctors are also the gatekeepers Of the system, and they're not very interested in replacing themselves or their job that they like best by machines.”
Pedro Domingos Aug 30, 2016 ▶ 25:20 #13 Pedro Domingos: The Rise of The Machines

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