Science

“When we submitted these papers and two-level reinforcement learning systems to nature and science, they just desk rejected them.”

“Science doesn't agree what triggers on a mast event yet”

“So much of science has kind of followed this sheep-like mentality, where everyone has to line up, agree to the same general theory, or you get outcasts, you don't get grant funding, you don't get tenure, you don't get jobs, you don't get invited to do lectures…”

“You're dealing with a level of prosperity in a world in which the Gini coefficients are blowing out. It's almost entirely due to the technology that is derivative of science, and the scientists are not participating.”

“And I think, you know, he did more disservice to science than anyone in, in modern history.”

“Specifically this is diseases like macular degeneration, which our clinical trial was done and we're about to do studies in retinitis pigmentosa and Stargardt's and a couple of their diseases.”

“What we ended up doing is we developed indigenously a state of the art gene therapy, which is probably going to humans next year.”

“So it took us about two years for post acquisition to get it to the place where this was possible, but we just in July got marketing approval in Europe for Prima to start commercially selling it there.”

“The first sales will happen in the coming weeks.”

“We use that constructively at science like that. So we know that that is. That is true because we can get alignments between animal brain neural recordings and AI model internal representations.”

“Second site, 10 years ago, they, so there's a company about a decade ago that had a retinal prosthesis that works differently than ours does. It did not get the type of performance that Prima does, but was Briefly approved. Cause then there's really nothing fo…”

“In the mid-twenty-tens, there's a gene therapy that works, that is only relevant in the first place for about five percent of patients in one narrow indication. And it really doesn't work that well. It gets .one lines of improvement. It kind of slows the rate …”

“The TAM will grow over time for this first version. It's on the scale of like hundreds of thousands of patients in the U S and Europe. So for the current version of Freeman is probably hundreds of thousands of patients. And then the next version, which is Goin…”

“While scientists have been synthesizing viral genomes for years to study diseases and develop vaccines, this is the first time AI has been used to design entirely new viruses that function in the real world.”

“In China, TikTok pushes out content about robotics, about aeronautics, about science.”

“Science is as an infinite token generator to train models at scale.”

“I think we're going to have that for science over the next two to three years. I do. Once discoveries start coming out and this field continues to mature even more.”

“There was just a paper in science, you know, one of the probably two most prestigious scientific journals in the world. It aggregated about 30,000 careers of musicians, scientists, athletes, And what it found was basically the thesis of range that the indicato…”

“Science is not really a bottleneck in, in most cases. Getting, there's plenty of great research out there, and there are many ways researchers are discovering molecules, but getting from a great research paper to an actual drug that helps treat patients and ge…”

“Science is not about curve fitting. Science is about finding the equation, finding the most compressive symbolic model of your pile of observation.”

“We finished a big clinical trial last year, which was published in the New England Journal of Medicine in the fall.”

“There's a big clinical trial in Europe across 17 sites, and there's a huge effect.”

“So we are submitting for approval now. It's not approved on, on the market yet. Hope to have that later this year.”

“The qualia of Prima is, is normal sight. It's black and white. It's only a, it's a small field of view, but it's vision.”

“I mean, I do think that you can get to close to native acuity, so kind of like your normal twenty-twenty vision. We're definitely not there yet, but I see a path to get there and be able to get Color and fill in a lot of the field of view. To be clear that it'…”

“And with our retinal prosthesis that we, what we saw in the trial was we can take a patient who's been unable to see faces for a decade and allow them to read every letter on an eye chart.”

“As far as I know, our clinical trial was the first time ever that form vision had been, like, had created, like, a coherent image in the mind's eye of a person.”

“One of the nice things about our device is that it doesn't We're somewhat agnostic to the reason that you lost the photoreceptors, and so we think it'll also work for retinitis pigmentosa, for Stargardt's, for these other indications.”

“We're actually just about to start a new clinical trial on, on inherited retinal disease which affects much younger people.”

“It was an empirical discovery of our study that if you excite the bipolar cells with an image, you get an image in the mind's eye, because that is clearly the critical processing step in the retina that you wanted to preserve.”

“What we were able to do were find optogenetic proteins that are so sensitive that they're sensitive to like indoor office lighting”

“And then we could target them to the bipolar cells, but that still has like five to seven years of clinical translation away if it ends up working, and there's a bunch of Pitfalls it could run into along the way”

“So we there's, it's one cell line and the, probably the single deepest area of IP on this is that we've hidden them from the immune system. So we're one of a really small number of companies that have, I think like pretty convincing, what we call hypoimmunogen…”

“But it comes with the potential of growing throughout the brain, forming biological connections all over the place. And I mean, that's what we've seen in, in the animal models. That's not in humans yet”

“The highest echelon of society today is obsessed. With their mortality and living forever, because for the first time in history they feel that it's not just religion, maybe science has a cure for death.”

“What is possible now for coding for science. That's the thing I'm most excited about for accelerating all kinds of research AI and otherwise for really accelerating the economy. I think that's like the right thing for us to most prioritize in terms of new capa…”

“In science, I don't think there is a finite appetite or a finite capacity for science. I don't think science is like a scarcity thing. Like there's, you know, 100 more discoveries left to be made and then we'll be done. And so like we're displacing jobs. I thi…”

“I think the enjoyers of science are also scientists. And so I think that it's kind of hard to imagine a scenario when there's not scientists as the consumers of science. And so I think if they're going to be consumers of science, they're also going to be some …”

“Engineering can exist by itself. Like if you give some kind of system, a goal of like making me a material that I can make a space elevator out of, you could be not participating in the beginning, the process of the middle, the process, and you just come by th…”

“I think we will see a set of things like that math conjecture that's proven where society outside of the realm of, like, my social circle starts to acknowledge the impact that AI's gonna have on science, and I think that will, in a good way, change the positiv…”

“There is exactly one demonstration of true quantum supremacy on a useful real world problem that was done by D wave by our company. It was published in the peer reviewed journal science about a year ago. What we did was we demonstrated that our quantum compute…”

“So our first investor was a company called Science. They're out in Santa Monica. They gave us a 100,000 dollar check.”

“So our lead program at Science is a retinal prosthesis. It's a chip that's implanted in the back of the eye. We just, we finished a major clinical trial last summer in age-related macular degeneration where patients that are unable to recognize faces have been…”

“And so there's so much of science that lives in like folklore and institutional knowledge, and that's kind of lost over time.”

“I go back to that sort of returns to intelligence piece where I think science is a problem that has some shape to it that really benefits from the LLM architecture. Like you just think about the corpus of scientific literature as like this vast pool of unstruc…”

“So our first investor was a company called Science throughout in Santa Monica. They gave us a 100,000 dollar check.”

“We should stop punishing scientists who fail. If they fail productively, let them publish in a journal to explain why they're, what they learned from it. Like that, Silicon Valley spirit I think needs to come to science a little bit more.”

“The standard for truth in science ought to be replication.”

“There's science that shows the more verbose you are, the more words you use when you speak, the less credible you appeal, you appear. So when you can get to your point with less words, you actually appear more credible.”

“One of those gated, SSM gated states-based models ended up on the cover of science because a great group of folks went and trained some DNA models. So that's Michael Polley, Eric Yuen from Stanford and the Arc Institute.”

“The way that, like, science proceeds right now is, like, you're trying to find, like, underlying, underlying explanations for things by, like, doing high-end studies on, like, lots and lots and lots of people and, like, doing, like, a linear regression to, lik…”

“Scientists, you try to understand the world. Engineers, you try to create new things, and very often, if you want to understand the world, you need to create new things. The progress of science very much is linked with progress in technology that allows to Col…”

“We're lucky right now because the state of AI as a science is incredibly new, and it truly has a wide green field. And unlike lots of other areas of science where if you look at something and you think, why hasn't somebody done X, Y, and Z? Unfortunately, ofte…”

“Today for every year that you're live, science is extending your life for about a third of a year.”

“And I think in within 10 years, the idea that you can be a sort of any science in any science without using AI models to help assist what you're doing will also be anathema.”

“Scientific validity gives not a rip about your personal preferences. And that, that, that, six years ago, nobody would have argued with that. Today, that's coming under fire.”

“Probably, yeah, I, I'd guess in like, 1020 years, we'll look back and it will be incredible how unsystematic science was back in the day.”

“Published a paper in the journal Science this week introducing GraphCast, which is actually a publicly available model that does weather forecasting using machine learned models. It's a thirty seven million parameter model.”

“We think that it's too early, and we think it's really, ah, damaging for the science, ah, to actually move into such an opaque regime, where you have A few companies basically doing the same thing, just not communicating about it spending billions of compute d…”

“When it comes to science, Just the applications of all this technology that's happening right now are still completely underexplored, whether it's, you know, using deep learning to get approximations of systems faster or figuring out how we can just accelerate…”