Psychedelics

topic on 12 shows · 33 statements across 22 episodes

the Y Combinator Startup Podcast We Live to Build BigDeal David Senra Lenny's Podcast My First Million the Startup Ideas Podcast WTF is with Nikhil Kamath How I Built This Big Technology All-In TBPN

33 statements about Psychedelics, every show

BIGDEAL Disclosure
Perez: Sober meditation is preferable to psychedelics for observing true reality
“And I've tried psychedelics, I've tried a bunch of different things when I was younger, and it's great. I think, you know, for some people that gives them tons of value, for me, I'd rather observe reality as it is.”
Diego Perez (Yung Pueblo) Sep 8, 2026 ▶ 30:48 5 Habits Constantly Draining Your Energy | Yung Pueblo
ALL-IN Assertion Not checkable as stated
Bryan Johnson: VCs put anti-psychedelic clauses in founder deal documents
“One investor told me that he even put it in the deal docs that, you know, if we invest, you're not going to do these psychedelics because they wanted to minimize the risk profile.”
Bryan Johnson Mar 26, 2026 ▶ 19:35 Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
ALL-IN Disclosure
Bryan Johnson: Psychedelics provided 30 to 40 years of psychological rejuvenation
“I felt like it was like 30, 40 years of Psychological rejuvenation. Like, you know, it's like to transform me back to a childlike state. That is insane. I don't get that from the sauna. Or from eating well. Or from sleeping well.”
Bryan Johnson Mar 26, 2026 ▶ 36:59 Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
DAVID SENRA Disclosure
Andreessen: I Have Never Used Psychedelics and Never Will
“It's gonna be clear. I'm not. I've never have. I'm never going to.”
Marc Andreessen Mar 15, 2026 ▶ 3:37 Marc Andreessen: The World Is More Malleable Than You Think
Andreessen: Psychedelics Cause Stressed Founders to Find Peace and Quit
“We see at Silicon Valley where, you know, kind of there, these guys get under pressure and, you know, they kind of feel anxious or whatever, and they decide that, you know, somebody tells them about psychedelics and they try it and they kind of come out the ot…”
Marc Andreessen Mar 15, 2026 ▶ 3:51 Marc Andreessen: The World Is More Malleable Than You Think
Rachitsky: A psychedelic trip gave him confidence to launch his newsletter
“There was psychedelics involved on this trip, and I just remember, so we went to Joshua Tree, I just sat down on this rock on a substance of some sort and this was as I was starting the newsletter, and I just remember sitting there for probably three hours in …”
Lenny Rachitsky Mar 12, 2026 ▶ 14:30 A behind-the-scenes interview with Lenny Rachitsky on building his newsletter and podcast
Pollan: Reducing egotism through psychedelics, art, or awe unlocks spiritual experience
“The tension in my mind is between spirituality and egotism. And to the extent you can reduce egotism, whether through psychedelics, but also experiences of art, experiences of awe, all of which kind of shrink the eye in a way that can be feel really good that …”
Michael Pollan Feb 25, 2026 ▶ 41:54 Can AI Become Conscious? — With Michael Pollan
ALL-IN Assertion Not checkable as stated
Tony Robbins claims identical psychological results can be achieved without psychedelics
“But my point is you get the same results without it.”
Tony Robbins Jun 19, 2025 ▶ 24:41 Tony Robbins | All-In Live from Miami
WTF Assertion Not checkable as stated
Bryan Johnson: Emergent evidence shows psychedelics are alternatives to pharma drugs
“There's a lot of interesting trials for veterans working on PTSD. You know, also psilocybin is very promising. So I'd say, yeah, psychedelics are having a resurgence in the US of interest where they got pretty buried by the government in the seventies, eightie…”
Bryan Johnson Feb 2, 2025 ▶ 41:01 Ep #21 | WTF is Longevity? | Nikhil ft. Nithin Kamath, Bryan Johnson, Prashanth, Jitendra & Seema · Nikhil Kamath
TBPN Opinion
Tim Ferriss promoting psychedelics to his massive audience was irresponsible and degenerate
“When I was in college, Tim Ferriss was directly or indirectly massively promoting psychedelic, like basically as like a lifestyle to the, one of the biggest podcasts in the world. Just telling everybody, like, how great psychedelics are, and I think that that'…”
Jordi Hays Dec 19, 2024 ▶ 43:14 You are NOT a Lottery Ticket (Peter Thiel Breakdown)
TBPN Opinion
Hays: Silicon Valley promotes psychedelics despite severe schizophrenia risks
“There's huge, huge, huge downsides to those substances, and there's too much in Silicon Valley, like, at least when I was in college, Tim Ferriss would be promoting, like, various psychedelics on his show to the super wide audience, and these are really, reall…”
Jordi Hays Dec 11, 2024 ▶ 1:31:52 How we became the fastest growing podcast (ep20)
TBPN Disclosure
Coogan and Hays presented at Hereticon arguing that psychedelics are terrible
“And our, basically our pitch was like, no, psychedelics are terrible.”
John Coogan Nov 3, 2024 ▶ 10:17 The Secret Billionaire Party (ep6)
Rossi: Abstains from psychedelics and alcohol to maintain clear consciousness
“I don't do drugs. I don't drink. And part of not doing psychedelics is really always being able to have that connection to my soul and not debase my consciousness in any way.”
Casey Rossi May 14, 2024 ▶ 8:52 She Made 7 Figures Selling What She Calls an Unhealthy Addiction
Courtney: Huge market for retreats without spiritual or psychedelic elements
“I feel like there's a place in the market for looking at things which are usually mixed with psychedelics and usually mixed with meditation or yoga and removing those elements and making it more practical.”
Jonathan Courtney May 1, 2024 ▶ 30:34 This legend gave away 3 crazy cash-flowing business ideas
WE LIVE TO BUILD Assertion Contradicted
Weisbrot: Research proves psychedelics cure depression
“There's tremendous amount of research that has proven without a shadow of a doubt that, that psychedelics have been amazing for curing depression. Curing depression. Curing treatment-resistant depression”
Sean Weisbrot Dec 13, 2022 ▶ 45:34 He Closed the Paper the Same Month He Buried His Wife
Urban: Psychedelics are cognitive tools to view internal thoughts objectively
“Psychedelics allows you to kind of like step outside and look at the sphere, and like maybe look at it from other angles, and like walk around it, look under it, and like, and that is incredible. Like it's an incredible tool.”
Tim Urban May 12, 2022 ▶ 10:38 Are We Alone In The Universe? (with Tim Urban)
Strauss: Psychedelics bridged the emotional integration gap where talk therapy failed
“Psychedelics were really the only tool that I found that even when it came to therapy and talking with sort of professionals in that regard, you know, there was always a disconnect between, you know, what I was hearing and what I was being shown and my ability…”
Tyler Strauss Mar 8, 2022 ▶ 6:36 Your Brain Has Only 3% of Its Vision in Focus Right Now
WE LIVE TO BUILD Prediction Not checkable as stated
Strauss: Psychedelics are likely among life's most meaningful experiences
“You should also feel, you know, assured that, you know, you're stronger than you imagine yourself to be, that you will be okay, and that it will very likely be one of the most meaningful experiences of your life, positive or negative.”
Tyler Strauss Mar 8, 2022 ▶ 23:42 Your Brain Has Only 3% of Its Vision in Focus Right Now
Weisbrot: Many people require multiple psychedelic experiences to see lasting change
“I think some people get that, but I think a lot of people also need multiple experiences to really see that change for themselves.”
Sean Weisbrot Mar 8, 2022 ▶ 27:28 Your Brain Has Only 3% of Its Vision in Focus Right Now
WE LIVE TO BUILD Assertion Contradicted
Strauss: Challenging psychedelic trips often yield better outcomes than easy ones
“Oftentimes people who have a challenging experience might actually come out of it feeling better than they did an experience that was perhaps easier.”
Tyler Strauss Mar 8, 2022 ▶ 31:23 Your Brain Has Only 3% of Its Vision in Focus Right Now
Holiday: Self-prescribing psychotropics to heal trauma risks irreversible brain damage
“I don't think you should fuck with your brain the way some of these people are fucking with their brains, and I think it's gonna, I think we're starting to see some of the ramifications of it with some of the stuff we're talking about here, but I think this is…”
Ryan Holiday Feb 8, 2022 ▶ 1:05:26 Ryan Holiday On The Economics Of Book Publishing
STARTUP IDEAS Prediction Open · timeframe Nov 2031
Bloom: Psychedelic criminalization will be substantially reduced by 2031
“I do think in 10 years, it's hard to imagine the level of criminalization around psychedelics as exists today, and so if you were out in front of it and building You should reap outsized rewards for doing that.”
Sahil Bloom Nov 18, 2021 ▶ 21:00 The NSFW Framework & the Magic of Community-Product Fit with Amanda Goetz | Where It Happens
Goetz: Psychedelic startups must vertically integrate to control dosing and quality
“So dosing is a huge issue. Quality control is a huge issue. So I think You have to vertically integrate this whole thing for it to be, I think, a really great company.”
Amanda Goetz Nov 18, 2021 ▶ 35:05 The NSFW Framework & the Magic of Community-Product Fit with Amanda Goetz | Where It Happens
Weisbrot: Small psychedelic doses can improve mental health and leadership
“I believe when respected, they can be great for managing stress, anxiety, depression, panic attacks, and possibly make us better human beings and better leaders at smaller doses.”
Sean Weisbrot Nov 11, 2021 ▶ 4:43 He Called It a State of Flow Multiplied by 100
Ahmed Rahim credits psychedelics with saving his life and expanding his worldview.
“Well, I always say that psychedelics saved my life, and definitely gave me an awareness of what the bigger world is like”
Ahmed Rahim Jul 5, 2021 ▶ 7:49 Numi Organic Tea: Reem Hassani and Ahmed Rahim
Mares: Superior recreational drugs are driving the non-alcoholic beverage market boom
“I honestly think one of the reasons I'm bullish on the non-alc space is, like, we are getting to the point where there are just better drugs. Like, if people want to, you know, alter their state of consciousness, I'm seeing a lot more friends that are like, Op…”
Justin Mares Jun 25, 2021 ▶ 48:23 How to launch a $100M DTC brand | My First Million #194
Ferriss: I Discourage People From Using Psychedelics More Often Than Not
“I discourage people from psychedelics more than I encourage.”
Tim Ferriss Dec 21, 2020 ▶ 1:18:35 Author and Podcaster: Tim Ferriss
Watts: Psychedelics can break rigid patterns of thinking and living
“When people are stuck in a very fixed pattern of thinking or of living, psychedelics can break that pattern.”
Dr. Rosalind Watts Mar 15, 2018 ▶ 5:51 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator
Y COMBINATOR Assertion Supported
Watts: Brain imaging shows psychedelics connect normally non-communicating brain regions
“They can provide this state of, when you look at the images of brain communication pathways, they go from this kind of segmented lines to this full on explosion where things that, parts of the brain that don't talk to each other all talk to each other, and sud…”
Dr. Rosalind Watts Mar 15, 2018 ▶ 6:00 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator
Y COMBINATOR Assertion Supported
Watts: Depression returned after three months without active post-psychedelic integration
“If you just give someone a psychedelic and you don't encourage them to make the most of the window of opportunity, then what we found with our participants is that the depression came back after three months or so.”
Dr. Rosalind Watts Mar 15, 2018 ▶ 24:21 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator
Watts: Psychedelics quiet frontal ego networks to facilitate somatic emotional processing
“The brilliant thing about psychedelics is that they turn off that kind of ego, frontal parts, and you can go into the body, and into the heart”
Dr. Rosalind Watts Mar 15, 2018 ▶ 32:26 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator
Watts: Psychedelics produce psychoanalysis-level self-understanding rapidly rather than over a decade
“Psychedelics are a bit more like psychoanalysis and that it's learning to understand, understanding yourself much, much better in a very deep way and making changes. And whereas with psychoanalysis it might be a bit more gradual, that people might get to know …”
Dr. Rosalind Watts Mar 15, 2018 ▶ 45:58 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator
Y COMBINATOR Assertion Supported
Watts: Meditation and psychedelics similarly deactivate default mode network
“Meditation does that too. It quietens down that mental control. The monkey mind. It's quieting the monkey mind. That's all I would say really we're doing with psychedelics and with meditation.”
Dr. Rosalind Watts Mar 15, 2018 ▶ 48:49 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator

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