Psilocybin

“And so we did the world's most studied, the most quantified experiment doing psilocybin, three doses at 25 milligrams of psilocybin.”

“So you look at my brain on psilocybin from Kernel, you see my patterns before, like the New York to London connection. You see my brain afterwards, and it's exactly what you said. New patterns are emergent. The old ones have quieted down. It's like a new map o…”

“What we found in psilocybin though, is it had, we found a first in human observation. It had this metabolic reset in the brain where my blood glucose before this was in the top. 99.5 percentile of all the population. Okay. After it went to the top 99.9 percent…”

“Five MEO DMT compared to psilocybin, like just absolutely like blasted clean. My default mode network. It felt like psilocybin dampens it, like it softens it, but this thing just annihilated my default mode network.”

“The data on microdosing psilocybin Are basically clear that it's not known to have any major effect on major depression or some of the other things that psilocybin is being tested for clinically including major depression, PTSD, et cetera.”

“At the end of six weeks, 53% of the people had no symptoms whatsoever, depression, nothing like it in history.”

“The data on micro dosing psilocybin are basically clear that it's not known to have any major effect on major depression. Or some of the other things that psilocybin is being tested for clinically including major depression, PTSD, et cetera.”

“Essentially microdosing is a slightly expensive supplement that you should notice. You know, I take a lot of supplements. I'm very into health and fitness and all that stuff. And like, I've never taken a vitamin C or multivitamin or more like, oh my God, like …”

“Psilocybin at both the macro and micro dosing level moves the brain in a beneficial direction. Whether you're cognizant of it or not, but if you're cognizant of it will move the brain in a beneficial direction even more rapidly.”

“Historically, it happens at five grams or 5000 milligrams to down to 3.5 grams or 3500 milligrams. Microdosing happens at the sub 10% level of that. So you're on the lower side, but microdosing kind of breaks down between 100 to 400 milligrams.”

“Used in conjunction is probably the most powerful, but that's kind of how you would delineate the two. One turns the lights on, the other just gently walks you towards the light every day.”

“There's techniques and a good coach will coach you through that, you know, allow, allow, allow, surrender, surrender, teach me. And you'll have a compression and it'll be terrifying momentarily. And then you're going to burst through and there will be a sponta…”

“There's a lot of interesting trials for veterans working on PTSD. You know, also psilocybin is very promising. So I'd say, yeah, psychedelics are having a resurgence in the US of interest where they got pretty buried by the government in the seventies, eightie…”

“Britt and I have a small mental health-related foundation called Sunrise, and we've invested in, The basic science around psilocybin. We were one of the first investors in the study that proved that psilocybin has over 80% efficacy for depression.”

“The people who have the largest egos tend to get a massive benefit from going on a hallucinogenic trip with psilocybin. Because it allows your brain to separate your ego from your consciousness in a way that allows you to understand the world from a different …”

“MDMA, psilocybin, and some of these other plant-based medicines, ayahuasca, are next, and they're doing studies on them now.”

“Early clinical trial results for many of these different compounds are really positive, really strong, both for the basic sort of common disease like depression, anxiety, but also for things that are quite a bit more challenging to treat. Substance use, eatin…”

“So if you think about a psychedelic trip, you can imagine that the psilocybin breaks apart those neural connections and then follow on psychotherapy Will reconnect them in a, air quote, healthier way.”

“Now there is some side effects, serious side effects that have emerged with psilocybin due to its binding to the five HT The two B receptor. It's either the two A receptor, the two B receptor.”

“I believe the difference between the two is that while marijuana has been legalized for recreational use, I believe psilocybin might be restricted to therapy-assisted sessions only.”

“And after I started taking the psilocybin within like a week or two, I got off of the high blood pressure pills. It's been several months now. My blood pressure is stabilized and I don't take the pills.”

“We went from something that was criminalized to then being medicalized, to then decriminalized, to then legalized, and that led to the creation of countless of companies in the category. I think the same thing is going to happen with psilocybin, with ketamine,…”

“I feel like marijuana is great if you have pain, physical pain, but I don't see there being much brain benefit where I see the research, the science showing that if you want to heal your brain, psilocybin and LSD are two of the fastest and best ways to do it”

“And the key finding was that psilocybin seems to deactivate the part of your mind or brain that is responsible for ruminating, for negative thinking on a loop.”

“So they, this, the study that I have, was involved in was a clinical study looking at 20 people with treatment resistant depression, and it was the first study of its kind in the UK”

“In the last study there was a low dose and a high dose session. The low dose session was 10 milligrams, and the high dose was 25, and they look pretty different, these sessions.”

“On a 10 milligram dose you would see, tend to see more psychodynamic stuff, so internal exploration. People feeling more emotional, feeling that they maybe get some insight into different parts of their life. And often there's struggle because the amount of ps…”

“With 10 milligrams, it opens it a little bit. And so the things come out and you might be having a conversation with a dead parent, or you might be thinking about a relationship that ended and It's like a very intense turbocharged therapy session, but you can …”

“Psilocybin is not nearly as effective if you're on antidepressants. It really takes the I mean, it takes the highs and the lows. Yeah, yeah, exactly. Yeah. It stops it from working, essentially.”

“It seems to, for most people last for about two or three months and then the depression starts to come back.”

“So of our 20 well, the first thing to say is that they all said that they would prefer it to any other treatment they tried.”

“So six of them, they were still well after six months. Three of them, it didn't work. And then for 11 of them, and this is, ah, yes, the majority of them, they were really well for three months, depression-free or very mild symptoms of depression. But then aft…”

“So our next study, we're going to be looking at psilocybin versus antidepressants. We're going to be comparing them.”

“With psilocybin it's completely different because the expert is themselves. They are the expert because what's happening, the healing power of this is something in the unconscious mind, their own unconscious mind is writing itself. There's a homeostatic princi…”