Clinical Trials

“There are drug candidates that are about to enter clinical trials and INDs that were sitting on the shelf and people didn't think were very viable at all.”

“We used to think Wuxi was just some cheap set of pipetting arms for contract pharmaceutical research, and now, 50% of all clinical trials are being done in China.”

“People get very focused on clinical trials because they're like the biggest line item. And they're important, don't get me wrong, but I think it's actually a bit of a red, red herring. Where, ah, yes, there are operational problems. Like, some studies are desi…”

“I don't know of one that's come through the machine driven discovery process, which is really machine plus human that's made it to the clinic yet, but they're coming.”

“We still haven't seen, and I think it's coming, but it hasn't happened yet. We haven't seen artificial intelligence or other technologies massively compress the amount of time it takes us to do the clinical development, the clinical trials, the enrollment of p…”

“In 20 years, we'll be able to know how a drug affects the body without ever actually testing it. And my prediction is actually Our AI models will be more predictive than today's clinical trials.”

“And there are as many clinical trials now in China as there are in the United States, and oftentimes they're bigger, which is to say that the amount of innovation and the surface area there is already exceeding what's happening in the West.”

“I think we now have the tools to be able to, in a very Kind of molecular way, microstage, what I call our biostage disease on a trajectory that isn't four stages, but it's 75,000 stages if you want. And the key for that is that you can then look at what mechan…”

“Women, you know, women have been historically underserved by medicine because people weren't studying women's physiology with, you know, in clinical trials up until the last 20 years or so.”

“Like, 80% of clinical trials just fail to meet enrollment targets, right?”

“Like, I'm working on, like, something, you know, in drug design or whatever to make big leaps and bounds, and small things for big cash flows can have a huge impact. So something for clinical trials could be huge, or even just picking, like, the order of rank …”

“It's the same thing in our field here, where if you can be even 10% better than the average, then you're going to be an all star because these events tend to be so Dramatic. So companies can go up two or three fold, a hundred percent, 200% moves overnight, or …”

“And we're queuing up for a clinical trial in twenty-twenty-five. So we're excited to start our clinical trial in twenty-twenty-five”

“The FDA only lets you queue up clinical trials to test drugs that are for diseases, but aging is not a disease state. Wanting to sleep fewer hours is not a disease state. Insomnia is, but wanting to just sleep fewer hours and be fully rested is not a disease s…”

“So no drug developed by ML has gone through clinical trials.”

“Because when you think about it, it's the one area where you really don't have the right type of training data, at least not obviously, because the question you're asking yourself is, if I make this therapeutic intervention in this patient, what is it going to…”

“That is one of the big things that causes drugs to fail is that you are trying to apply it more broadly. If I'm being cynical, sometimes it's supposed to maximize the revenues that you can get from a drug versus trying to figure out exactly in which patients i…”

“Being on an antidepressant so far is an exclusionary criteria in probably all the clinical trials right now.”

“What we are showing is Is that we are raising the, an accurate alarm flag seven to eight days before very, I mean, in very high rates, like 95%, ok? 95% of the hospitalization cases of the clinical trials of the sample we sampled. We are showing a very obvious…”

“Every day you shorten clinical trials is a million dollars that is saved to the healthcare system.”

“It's usually bigger, longer deals to longer term engagement. So, for example, a clinical trial that wants to be accelerated, it could be a six-figure deal to work with us to help accelerate that trial.”

“On the study design side, you know, it takes anywhere from nine to 12 months to do that. We're cutting that down to weeks and eventually days.”

“And what I think we'll start to see is, especially as new statistical methods come online, that real world evidence will be very useful, in some ways will be more useful than what you can do in a clinical trial, both due to power and due to the fact of real li…”

“Most clinical trials, upwards of 90% or worse, don't get filled, and it's because there's no frictionless way for a clinical trial's inclusion-exclusion criteria to detect a candidate patient.”

“When patients all have access to their data, They could form a coalition and ask for a certain clinical trial.”

“There are estimates now from various sources that believe you could take out 20% of clinical trials costs if you were to actually to really deploy technology at scale.”

“So we've built an operational command center. Take us, as I said, two and a half years to build it. We call it sense. And what it enables us to do a team sitting centrally in our headquarters to look at all of our clinical trials in the world. And AI is predic…”

“When I think about, first of all, I would say just in general in sensors is another place where there's been a lot of hype Above what, of expectations. I mean, we've been really trying to explore the use of sensors in clinical trials now for, in my own experie…”

“If you do that invention, you do that intervention in humans, you're going to have to wait A really long time to know whether it actually worked, and so that clinical study is very difficult if you don't have a secondary endpoint that you can measure.”

“Most clinical trials don't result in there, there's an excess of 80% waste in, in funding of clinical trials today, and yet this is life-saving research.”

“So we don't touch that piece of the market. That's about four to five percent of patients will go on a trial. We look at the 95% who are not on a trial.”