Alzheimer's

“I do believe all this amazing AI technology is people, I think people's lifespans are going to increase exponentially. Not until like 200 years, but we're not going to be living to 75, but we're going to be more commonly living to a hundred or a 105. There'll …”

“So when I was a fellow, so I did my fellowship in geriatrics and nutritional sciences at Wash U, and one of the risk factors for Alzheimer's was very poor sleep over time. And sleep apnea.”

“Alzheimer's, cardiovascular disease, Diabetes, obesity, that these are all symptoms of unhealthy skeletal muscle”

“If you are not training and you are sedentary, do not eat a high carbohydrate diet, or you are essentially giving yourself an oral glucose tolerance test three times a day. We don't want that. Because as we have these metabolic dysfunctions, she then is at a g…”

“I tell people I can confidently say I will never develop Alzheimer's.”

“And interestingly enough, you know, when people have dementia and Alzheimer's, they usually die because of, they can't eat. So that's a bigger problem than, you know, the dementia itself.”

“You can still dramatically reduce the baby's risk, for example, for something like Alzheimer's, Which is then strongly associated with longevity or breast cancer or coronary artery disease, which are the top killers in the United States today.”

“For example, with Alzheimer's, you get a P-Tau, two 17. It's modifiable by lifestyle. You check it again in, you know, six months or a year. Now you have two data points, and you can say, you know, with all the other data that's available, when you're gonna se…”

“We have a company that does an eye scan for Alzheimer's 10 years before you see it.”

“There is the genetic component of having dementia or having Alzheimer's, and then there's also the epigenetic component, where you have the ability to transform your genes through your lifestyle, through the foods that you eat, through the exercise that you do…”

“And like, the effects in some of the recent studies on the GLP-I agonists is it's not just weight loss, but there's like anti-inflammatory effects. They had good phase two on Alzheimer's. There's kidney disease. Hypertension. And crazy enough, they've got an i…”

“There's a study in Japan where people who laughed more frequently not only lived longer, but, like, significantly longer, like, 20 to 30% longer than their other peer group, and this was a long-form study over a series of decades, but also had a decrease in di…”

“Is all the issues that we are seeing, obesity, diabetes, cardiovascular disease, Alzheimer's, is this all a fat problem? No. It begins in skeletal muscle first. Decades before.”

“The sad facts are that once we get to 85, we're about fifty-fifty likely to have Alzheimer's.”

“When we think about disease, we think of disease as something bad happening to us, but a lot of that stuff is exacerbated with age, and that age itself is like so much of the challenge that we get Cancer and Alzheimer's and type two diabetes with such greater …”

“Truly reset the age of the body and diseases of aging, like Alzheimer's and heart disease, even cancer will go away if we become young again.”

“All the companies that we invest in have drugs that have worked not just in kind of mouse models of Alzheimer's typically, but also diabetes and heart disease, and kind of typically the pathways that we invest in have been tested in and work in almost every Ag…”