Drugs
topic on 9 shows · 20 statements across 17 episodes
Acquired 
American Optimist 
the Knowledge Project 
My First Million 
No Priors 
Capital Allocators 
the a16z Podcast 
All-In 
TBPN
20 statements about Drugs, every show
Carlson: SSRIs restrict emotional range rather than fixing chemical imbalances
“They prescribe drugs which do not correct a chemical imbalance. They limit emotional range.”
Handmer: Future Life-Extension Drugs Will Have Been Buildable Since the 1930s
“I think that when we figure out how to drastically increase human lifespans, it will turn out that we would have been able to build these drugs since the 19 thirties.”
Dr. Jim Loehr: Sledgehammer mandates fail to curb adolescent risky behavior
“And some of it, like drinking and driving or taking drugs, they're really, really dangerous areas to talk about. And just swinging a sledgehammer probably is not going to get through Mission Control Central. You're going to have to spend time getting them to t…”
Danish law prohibited patenting pharmaceutical drugs in the early 1920s
“Now, funnily enough, at this particular point in time, it turns out you actually can't Patent drugs in Denmark.”
Pande: FDA rejects new drugs that are cheaper but equal in efficacy
“If you had a drug that was as good as the best drug, but cheaper, That still can't get that won't go by the FDA because they actually has to be better than the last drug, even if it's not better scientifically, but it's better in other ways.”
Robbins: Placebos equal prescribed drug results at least 25% of the time
“You can take any result you get with virtually any drug, and at least 25% of the time, the placebo will do the same result in almost every study I've read.”
Smith: Microgravity Enables Novel Pharmaceutical Compounds Impossible to Synthesize on Earth
“The physics when you're on earth due to gravity and some of the other forces that don't exist in space results in you not being able to create certain chemical structures, and that impacts the way that drugs can be basically ingested or administered. And so th…”
Koller: Drugs with biomarkers are twice as likely to succeed clinically
“There's you know, there's research that shows that drugs that have a biomarker are about twice as likely to be successful in the clinic as ones that do not.”
Koller: Drugs backed by human genetics are twice as likely to succeed
“There's also data that show that drugs that have support in human genetics are twice as likely to succeed as ones that do not”
Koller: Broad patient targeting to maximize revenue causes drug trial failures
“That is one of the big things that causes drugs to fail is that you are trying to apply it more broadly. If I'm being cynical, sometimes it's supposed to maximize the revenues that you can get from a drug versus trying to figure out exactly in which patients i…”
Hillenmeyer: Roughly 10 fungal genes typically encode a drug compound
“It's usually about 10 genes encodes one drug.”
Garfinkel: Pharma Adjacencies Capture Upside Without Binary Trial Failure Risk
“Pharma adjacencies, which is companies that play in the pharma space, but it's without a drug, so they have the same upside potential, because pharma has big upside potential, but without the binary risk that the drug would fail in phase three.”
Casdin: Drug development success rates will rise and costs will fall
“Our industry over the next 10 years, and I can say that comfortably, drugs are going to be higher chance of approval, higher chance of efficacy. Probability of success is going to go up continually, and cost of that success is going to come down.”
Lim: Dietary choices can impact health as much as pharmaceutical drugs
“We eat three, sometimes more meals a day, so the foods that we eat can be as impactful to our health as the drugs that we take.”
Scientific understanding of approved drugs remains severely limited
“Even for drugs that are on the market, and have been used for many years, our ability to really describe what they actually do is very limited.”
Kaditz: Pharmacogenomics is the lowest-hanging fruit in genomic applications
“Using genetics to determine which drugs you're most likely to respond to. I think that that is, like, the lowest hanging fruit.”
Samuels: Smartphones touch 250,000 patents while drugs touch only 30-40
“The average smartphone is covered by 250,000 patents. The average drug by 30 or 40 patents.”
Digital therapeutics can outperform traditional drugs for diabetes treatment, says Vijay Pandey
“And I believe actually Modis had done this, and in this case, one can show actually that, that digital therapeutic is not just comparable to the drug, but in, and generally can exceed the capabilities of the drug.”