Bryan Johnson

“He had 1200 people apply for his million dollar per year thing. 1200.”

“By the way, I'd like to say there's a white space opportunity because there's no real female version of Brian Johnson yet. I think there will be, that's going to happen soon.”

“And so we did the world's most studied, the most quantified experiment doing psilocybin, three doses at 25 milligrams of psilocybin.”

“So you look at my brain on psilocybin from Kernel, you see my patterns before, like the New York to London connection. You see my brain afterwards, and it's exactly what you said. New patterns are emergent. The old ones have quieted down. It's like a new map o…”

“What we found in psilocybin though, is it had, we found a first in human observation. It had this metabolic reset in the brain where my blood glucose before this was in the top. 99.5 percentile of all the population. Okay. After it went to the top 99.9 percent…”

“We've had a lot of success rejuvenating my heart and my lungs and muscle and body fat, but rejuvenating the brain is very hard.”

“If I just subjectively compare my experience with five MEO to having a better diet and exercising every day and sleeping well and doing the sauna and doing hyperbolic oxygen therapy, this was more efficacious than all of them. In terms of the reset of me as a …”

“We've knocked out all the stuff you can do today. Like we've gone through it all, done it all. The next gen therapies are just not there yet. So we're looking at mitochondrial rejuvenation.”

“That's like a two-year project.”

“We have the organoids stood up. We haven't done our first takes yet.”

“They've done, I mean, they've made remarkable progress. They figured out how to computationally Solve the discovery process. And so they they're much faster than they initially thought.”

“In the future, like, I think we'll look back and we'll see GLP ones as the first big drop. Like what I can just inject myself and like it solves hunger and totally. Yeah. And then the second will probably be something like new limit or one of these Fox, one of…”

“I felt like it was like 30, 40 years of Psychological rejuvenation. Like, you know, it's like to transform me back to a childlike state. That is insane. I don't get that from the sauna. Or from eating well. Or from sleeping well.”

“No, I mean, it's 15% of my daily caloric intake. I consume more olive oil than any food.”

“So it's called Immortals. A million dollars a year. And it's my exact protocol. So my doctors, my concierge team, all the testing infrastructure.”

“So for me, over the past five years, we are counting yesterday we have a few billion data points on me over the past five years. And so, then if you say, what of those few billion data points are usable? Probably a few hundred million.”

“We are going to deliver autonomous health. And so like there's self-driving cars, there's self-writing software. This is autonomous health. So we're building AI that just says do this.”

“Some peptides have done the clinical work, like there's hepatitis, but then there's a whole bunch of the class of peptides that we have no human data on.”

“I think that we will exceed them in value in many core areas. Because they, you, they can take, you know, well-structured, well-funded clinical trials. But then other things like peptides that are very promising. They're not going to have the clinical work.”

“Our goal is to create the world's largest data set across all these sectors. And then you basically can create an ecosystem where the person could be paid for their data. So they collect the data, they're starting to the experimentation. Companies come in and …”

“Ok, my prediction for twenty-twenty-six is it will be the year that YOLO dies. We will begin transforming ourselves from a you only live once to don't die.”

“We are giving birth to some kind of super intelligence. We don't know what it is. We don't know what kind of scale, but it's big. It's important.”

“Our health will be run on our behalf. So right now we have to chase down all our food, we have to chase down protocols, we have to chase down evidence, but it's not going to be that in the future. It will be that it will just be run for us.”

“It's probably the most successful anti-aging drug ever built.”

“I think we're probably going to hit peak in something like. 2032, you know, like, ish. Like. A few things will hit when people will be like, it's here.”

“Basically, somebody's gonna set up shop in longevity and ride a multi-trillion dollar ride. So that's what we're trying to do, is we're trying to just be home base, win the early innings of longevity, and then ride for the multi-trillion dollar market.”

“So basically if you look at the landscape and health right now, nothing is proprietary. You basically got wearables from all these from providers, you have food from providers, you have biomarkers, like nothing's proprietary. And so the winner's going to have …”

“It's very unlikely. They've done such a great job executing. I sold Braintree in 2013, so they've been building 12 years since. They've done such a good job making that airtight.”

“My left, so I'm 47, my left ear is 64 years old.”

“Basically, I have the best biomarkers of anybody in the world.”

“So you guys, the single best thing I've learned out of everything I've ever done is your resting heart rate before sleep is the best thing you can do for your health.”

“Don't die is the next major ideology on par with democracy, capitalism, Christianity, Islam.”

“He was actually when I first met him, I mean, he was so, you know, the reputation was he was really sensitive to criticism and he was kind of like thin skinned and since he got famous, he just like revels at all these people crapping on him. And I don't actual…”

“Like he used to come to Silicon Valley and nobody would meet with him and he could never raise money for everything. And then now I see him walk into these rooms and everyone's like wants to talk to Brian, but they also, they're all trying to learn how to live…”

“And so I think some people sometimes question like, Does he know the science at all? He, like, really does. I mean he can, like, it's impressive. He can talk at length about all this stuff.”

“We'll beat a hundred million dollars in less than 12 months”

“CPG sucks. It's the worst business in the world.”

“I did eight months of perfect sleep. A hundred percent sleep every night to show I could do high quality sleep.”

“Yeah, you know, I did it because my dad was experiencing cognitive decline, and he called me in a panic, and he said, I will do anything to save my consciousness, and so I did it for him.”

“I think Brian Johnson has a very unconventional view, but I think Brian Johnson is prescient, and I think his view that we may never have to deal with death in the conventional sense or aging in the conventional sense is going to be something that Even by the …”

“And of the top three things, what I'll boil it down to is the top one thing, which is like, 80% of the 80%. It's all about sleep.”

“The algorithm. So like if the objective is don't die, Then it's just a systematic process of what inflicts damage upon the body. And then how do you mitigate that damage? Like how do you block it or, you know, how do you mitigate it? And so in that regard, it,…”

“I mean, our skin's like the, one of the biggest reveals of health, right? Like, you can't fake skin.”

“I've been measuring my methylation patterns every week for the past couple years, so more than anyone out there.”

“I mean, so when I was 34, so I, yeah, in one year's time, I sold my company. I got a divorce. I left my religion and I came out of depression. So all in one year's time.”

“Like it warps all of your relationships. It's like every, every person in your life now has, it's like you have three people in the relationship. It's like you, your money and the person.”

“So actually next week there's going to be, do you know Polymarket? Yeah. They're launching a market on my nighttime erections.”

“No, there's not good evidence. That's a good modality. I take it via capsule form. I take NR, yeah.”

“I think there's only one thing going on. We're giving birth to super intelligence. Nothing else matters besides that. We're giving birth to a form of intelligence that's going to change our existence unfathomably, and in timeframes which are hard for us to und…”

“That don't die is the most played game by every, every human on this planet every second of every day. It is our zeroth order priority every second to not die. Every breath we take, all of our metabolic energy is going to not die in this moment. That's true fo…”

“By 20, 27, the same time when we think that These AI agents will be as good as our best AI researchers, that there's a billion of us around the world that are practicing, don't die, economically, politically, religiously, morally, socially, ethically, all the …”

“If you tell the AI, AI, The objective of your existence is intelligence doesn't die. Humans don't die. You don't die. Our planet does not die. That's the goal.”

“The process that people should go about doing is not trust anyone's philosophy. They should trust the data. And so there's multiple paths to get to the same destination. Just trust the data.”

“For breakfast, I have broccoli, cauliflower, black lentils, garlic, ginger. For my next meal, I have macadamia nuts, walnuts, flaxseed, pomegranate juice, Berries, pea protein, and hemp protein. My final meal of the day is some kind of combination of berries, …”

“I took majority of those and put it into a drink. I was like, I still take basically a hundred pills a day. Just now they're in part of a drink. So it's easier to take. And so then four-year pill capsule form.”

“I wouldn't take anything unless you can measure it.”

“I mean, it's the side effect profile. It's the, it messes with lipids. It messes with blood glucose. I had small tissue infection soft tissue infections. It raised my resting heart rate. And so we knew we had these side effects, but we just wondered, like, whe…”

“I want something very simple. I want the, those who exist in the 25th century, I want them to say, he got it. He got it. He got that moment right. He saw it.”

“What I have problem with is some of the experimental therapeutics, the hundred pills and everything. Most of these things are unvalidated. So as long as he's keeping those experiments in check and he's doing it on himself, As a science experiment? Good. I'm ju…”

“So a recent study showed that women with high levels of BPA produced substantially fewer eggs and ovulation. That contaminants reduces the body's production of eggs.”