Bryan Johnson: Stopped rapamycin due to lipid spikes and elevated heart rate
Bryan Johnson · Ep #21 | WTF is Longevity? | Nikhil ft. Nithin Kamath, Bryan Johnson, Prashanth, Jitendra & Seema · Nikhil Kamath · Feb 2, 2025 · at 1:34:17
Bryan Johnson explains why he discontinued rapamycin, one of the most widely cited longevity compounds, during his Blueprint protocol experiments.
0:00 / 0:20exact quote · 20.8s
▶ Watch the full episode on YouTube → 720p mp4 · rendered on demand · StarZero watermark
“I mean, it's the side effect profile. It's the, it messes with lipids. It messes with blood glucose. I had small tissue infection soft tissue infections. It raised my resting heart rate. And so we knew we had these side effects, but we just wondered, like, whether the benefits outweighed you know, whether it was a fair trade-off, but I don't think, we just don't think it is, and so .”
quote is from the automated transcript, cleaned for reading: filler sounds and stutters are removed, nothing is rephrased. names can be misheard (the analysis reads context, assessments check outside sources). how →
More from Bryan Johnson
Bryan Johnson: AG1 costs under $10 to make and pays 20% influencer commissions
“So the cost of their goods to source their actual ingredients is less than 10 dollars, probably seven dollars. They sell it for one time, 99 dollars and subscription for 79. They pay influencers
20% of that. So every time a health influencer plugs AG one, they…”
Polymarket Is Launching a Prediction Market on Bryan Johnson's Nighttime Erections
“So actually next week there's going to be, do you know Polymarket? Yeah. They're launching a market on my nighttime erections.”
Bryan Johnson: Very few high-functioning people routinely use cannabis
“I don't know of many high functioning people who routinely use marijuana, maybe occasionally for enjoyment, but very few like actual regular practitioners.”
Bryan Johnson: Birthing superintelligence is the only thing that matters on Earth
“I think there's only one thing going on. We're giving birth to super intelligence. Nothing else matters besides that. We're giving birth to a form of intelligence that's going to change our existence unfathomably, and in timeframes which are hard for us to und…”
Bryan Johnson: AI agents will match top AI researchers by 2027
“By 20, 27, the same time when we think that These AI agents will be as good as our best AI researchers, that there's a billion of us around the world that are practicing, don't die, economically, politically, religiously, morally, socially, ethically, all the …”