Antidepressants

topic on 7 shows · 16 statements across 12 episodes

the Y Combinator Startup Podcast We Live to Build the Knowledge Project BigDeal the Startup Ideas Podcast All-In 20VC

16 statements about Antidepressants, every show

Weisbrot: Many Americans use antidepressants to numb reality rather than face hardship
“And I think a lot of them are on antidepressants because it's easier than not being on antidepressants. It's easier to numb yourself than to be part of reality. And to accept that things are not always as easy as you want them to be.”
Sean Weisbrot Jul 11, 2025 ▶ 25:09 People Learn What They Think When They Hear Themselves Speak
WE LIVE TO BUILD Assertion Partly supported
Sean Weisbrot: Psilocybin acts as a serotonin inhibitor without antidepressant withdrawal symptoms
“Mushrooms are a natural serotonin uptake inhibitor. Just like these you know, these antidepressants, however, they don't have the awful withdrawal symptoms. You know, it doesn't take months to get off of. You can start it and stop it whenever you want. So it's…”
Sean Weisbrot Jun 3, 2025 ▶ 4:39 One Turns the Lights On. The Other Walks You Toward Them.
BIGDEAL Assertion Contradicted
Codie Sanchez: 60% of US women under 30 have taken antidepressants
“For women under 30 in the US, 60% of them at some point in time have been on an SSRI or an antidepressant.”
Codie Sanchez Nov 30, 2024 ▶ 31:53 Kim Kardashian’s Personal Trainer: Transform Your Body In 1 Month | Senada Greca
BIGDEAL Assertion Contradicted
Senada Greca: 150 weekly exercise minutes is twice as effective as antidepressants
“Just as little as a 150 minutes a week of physical activity can have almost twice as much of the effect as an antidepressant or as a an anxiety medication can have.”
Senada Greca Nov 30, 2024 ▶ 32:35 Kim Kardashian’s Personal Trainer: Transform Your Body In 1 Month | Senada Greca
KNOWLEDGE PROJECT Assertion Supported
Exercise and Dancing Outperform Psychotherapy for Treating Mild to Moderate Depression
“And the reason is, is they've measured things. You know what better for mood, for mild to moderate depression than psychotherapy or antidepressants? Dancing. Yeah. Exercise. Dancing.”
Abigail Shrier May 21, 2024 ▶ 47:21 Abigail Shrier: Why the Kids Aren’t Alright
20VC Disclosure
Harry Stebbings: Antidepressants flattened emotional highs and prevented genuine happiness
“Like, I, I've been on antidepressants too. I find, you know, not everything has been easy too. I hated the level all the time. I didn't ever feel happy either. Like, really happy.”
Harry Stebbings Apr 5, 2024 ▶ 26:37 Mario Schlosser: "How to Deal with a 94% Decline in Market Cap" | E1136 · 20VC with Harry Stebbings
20VC Insight
Mario Schlosser: Antidepressants can block deep intuitive insights needed by founders
“That insights, being on the drug might not come to you, and you might end up actually doing the wrong thing because the drug sort of cuts out some of these deeper insights that you should, that should flood into your consciousness.”
Mario Schlosser Apr 5, 2024 ▶ 27:42 Mario Schlosser: "How to Deal with a 94% Decline in Market Cap" | E1136 · 20VC with Harry Stebbings
Tombot is designed to replace antidepressants and opioids in elderly patients
“Looking for things that can replace an antidepressant. Something that can replace a an opioid type of medication. Is really the mission that Tombot is on and the void that we felt is that children or loved ones, other loved ones or pets are frequently what peo…”
Tom Stevens Dec 26, 2023 ▶ 24:29 Dogs Evolved Unique Eye Muscles Just to Make You Care for Them
ALL-IN Assertion Supported
Calacanis: Teen antidepressant prescriptions rose 38% between 2015 and 2019
“Express Scripts, a mail order pharmacy recently reported that prescriptions of antidepressants for teenagers rose 38% from 2015 to 29.”
Jason Calacanis Sep 10, 2022 ▶ 1:07:36 E95: Winter is Coming, Europe's energy crisis, Kim Kardashian's new PE firm & more
WE LIVE TO BUILD Assertion Supported
Current antidepressant use is an exclusion criterion in psychedelic clinical trials
“Being on an antidepressant so far is an exclusionary criteria in probably all the clinical trials right now.”
Dr. Linda Strauss Apr 28, 2022 ▶ 22:45 Psilocybin Breaks Neural Connections - Then Therapy Rewires Them
WE LIVE TO BUILD Assertion Contradicted
Weisbrot: 80% of American adults take antidepressants
“Eight out of 10 adults in America are on some sort of antidepressant.”
Sean Weisbrot Feb 2, 2022 ▶ 21:11 Psilocybin Made a Purely Logical Man Say I Love You to His Brother
STARTUP IDEAS Prediction Not checkable as stated
Bloom: Psychedelics will fundamentally disrupt and replace psychiatric medications
“Science is starting to show in a meaningful way that psychedelic compounds can be extraordinarily useful for people dealing with depression. I mean, we're gonna, it's gonna completely separate and completely change antidepressants, anti-anxiety medicines, and …”
Sahil Bloom Nov 18, 2021 ▶ 10:41 The NSFW Framework & the Magic of Community-Product Fit with Amanda Goetz | Where It Happens
Weisbrot: Pharma and Healthcare Industries Design Medications for Profit, Not Healing
“Pharmaceutical industry and the medical industry and the hospitals are all in it together to get you onto opioids, painkillers, antidepressants, anti-anxiety medications, anything like that is designed not to help you. It's designed to keep you giving them mon…”
Sean Weisbrot Nov 11, 2021 ▶ 34:49 He Called It a State of Flow Multiplied by 100
Watts: Antidepressants are short-term fixes ignoring depression's root causes
“You know, as a short-term thing to get people through a crisis time, I think sometimes it can be really helpful, and for some people it works, but for a lot of people it's a short-term fix that doesn't really change the causes of the depression.”
Dr. Rosalind Watts Mar 15, 2018 ▶ 9:00 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator
Y COMBINATOR Assertion Contradicted
Watts: Antidepressants blunt and essentially stop psilocybin from working
“Psilocybin is not nearly as effective if you're on antidepressants. It really takes the I mean, it takes the highs and the lows. Yeah, yeah, exactly. Yeah. It stops it from working, essentially.”
Dr. Rosalind Watts Mar 15, 2018 ▶ 20:44 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator
Y COMBINATOR Disclosure
Watts: Imperial College team will compare psilocybin directly against antidepressants
“So our next study, we're going to be looking at psilocybin versus antidepressants. We're going to be comparing them.”
Dr. Rosalind Watts Mar 15, 2018 ▶ 28:51 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator

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