The Ledger, every show
Every statement that passed quotation and attribution checks, across all 44 shows. Pick shows below, then mix any filter with any other.
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every show 44 of 44
Johnson: I became the most measured person in human history
“I became the most measured person in human history.”
Johnson: I logged eight months of perfect sleep on my wearable device
“I recently logged eight months of perfect sleep using my wearable, which no human in history had ever done.”
Johnson: Weight-to-Rep Ratio and VO2 Max Peak at Age 18
“It's because you max out your weight to rep ratio at age 18. So even though you can lift more in your twenties and maybe even your thirties, your ratio peaks at 18 The same is true with your VO two max, your cardiovascular fitness.”
Johnson: Blueprint is history's first project to rejuvenate every organ
“We are the first endeavor in history to focus on trying to rejuvenate every organ of the body.”
Johnson: My son achieves similar Blueprint biomarker results on an omnivorous diet
“Yeah, pretty similar.”
Johnson: Emerging evidence shows plant-based diets are superior for longevity
“I do think that there's every day, there's more evidence coming out suggesting plant-based diets are more conducive for longevity. So I think the evidence in time will speak for itself, but right now it's of all the battlefields I could choose. This is not the…”
Bryan Johnson: Kernel brain measurements show poor sleep substantially reduces willpower
“I actually measured my brain at my brain interface company, Kernel. I looked at my brain based upon sleep patterns, and I saw, we saw in my brain, I had less willpower when I had a poor night sleep, when I had less REM and less deep. And so, yes, when you have…”
Bryan Johnson: Evidence does not support hot and cold exposure for longevity
“The hot and cold therapy didn't make our cut because it doesn't increase lifespan, healthspan. Rather, the evidence was not strong enough for my team to recommend it to be cut into the protocol.”
Bryan Johnson: Cultural celebration of tanned skin will not survive long-term
“This culture of a tan skin is not going to survive much longer because it will just naturally push in the direction where We generally over a long enough time horizon move towards more positive habits for society. Sometimes it takes a very long time, but I thi…”
Johnson: Blueprint is a philosophical endeavor for intelligence, not just wellness
“Blueprint to me is the best idea I've ever come up with and the most practical idea I've ever come up with to address that. And so from the outside perspective, it appears to be health and wellness and anti-aging and whatnot. That's all true, but really it's a…”
Johnson: Relying on willpower to resist modern food environments is a losing game
“Trying to win this game with willpower is a losing game. If you put yourself in a situation where you have option A and option B, you're probably going to lose 50% of the time or more.”
Bryan Johnson: Hard science VC is less competitive than software investing
“I found it to be less competitive and less cutthroat and Then say, for example, you find the behavior and investing in a particular app or software company where you have, you know, dozens and dozens of companies that could are viable capital sources. There's …”
Bryan Johnson: OS Fund invests on multi-decade horizons for transformative returns
“My benchmark of is the goal is to benefit the lives of billions of people for generations to come. It's like rewrite the major operating systems of our society. And so if a company can do that and they can make money doing it, Then I don't really care what the…”
Bryan Johnson: Ginkgo Bioworks making biology programmable will transform Earth
“Ginkgo Bioworks, because they are making biology a predictable programming language, which will radically transform planet Earth.”
Bryan Johnson: Blueprint conducted the world's most quantified psilocybin experiment
“And so we did the world's most studied, the most quantified experiment doing psilocybin, three doses at 25 milligrams of psilocybin.”
Bryan Johnson: Blueprint targets mitochondrial rejuvenation after exhausting existing treatments
“We've knocked out all the stuff you can do today. Like we've gone through it all, done it all. The next gen therapies are just not there yet. So we're looking at mitochondrial rejuvenation.”
Bryan Johnson: Sprinting is an underappreciated longevity therapy
“Sprinting is one of the most underappreciated longevity therapies.”
Bryan Johnson: Developing in-house FOXL-III gene therapy is a two-year project
“That's like a two-year project.”
Bryan Johnson says olive oil makes up 15% of his daily calories
“No, I mean, it's 15% of my daily caloric intake. I consume more olive oil than any food.”
Bryan Johnson collected billions of biological data points on himself over five years
“So for me, over the past five years, we are counting yesterday we have a few billion data points on me over the past five years. And so, then if you say, what of those few billion data points are usable? Probably a few hundred million.”
Bryan Johnson says Blueprint is building AI to deliver autonomous health
“We are going to deliver autonomous health. And so like there's self-driving cars, there's self-writing software. This is autonomous health. So we're building AI that just says do this.”
Bryan Johnson notes many popular peptides have zero human clinical data
“Some peptides have done the clinical work, like there's hepatitis, but then there's a whole bunch of the class of peptides that we have no human data on.”
Bryan Johnson says Blueprint will let users sell their personal health data
“Our goal is to create the world's largest data set across all these sectors. And then you basically can create an ecosystem where the person could be paid for their data. So they collect the data, they're starting to the experimentation. Companies come in and …”
Johnson: Major hotel chains want to launch Blueprint health retreats
“We have about a dozen groups around the world that want to stand this up, and some of the biggest hotel chains around the world.”
Johnson: Blueprint will license its IP rather than open physical clinics
“We probably will not do physical clinics. It's just too much on the real estate. And so, but we'll probably license it out. We'll probably do the digital model.”
Johnson: The longevity hype cycle will peak around 2032
“I think we're probably going to hit peak in something like. 2032, you know, like, ish. Like. A few things will hit when people will be like, it's here.”
Bryan Johnson: Brain atrophy from aging reduces single-leg balancing ability
“As you age, part of your brain that keeps you well-balanced atrophies, and you can't maintain the balance very well, so kids are very good at this. As you age, you get worse, ok?”
Bryan Johnson's single-leg balance test benchmarks for determining biological age
“So, if you are, ah, between 15 and 30 seconds, that's roughly age 20 to 40. Seven to 15 seconds, you're between 40 and 60, and zero to seven, you're 60 plus. As an age category, ok?”
Bryan Johnson: At age 47, my left ear's biological age is 64
“My left, so I'm 47, my left ear is 64 years old.”
Johnson: Individuals Cannot Control Air Exposure Unlike Food and Water
“You can filter almost any water and get it to be pure. With food, you can grow your own food, but with air, you have no control. You're in a system.”
Bryan Johnson: Skin is one of the biggest indicators of health
“I mean, our skin's like the, one of the biggest reveals of health, right? Like, you can't fake skin.”
Bryan Johnson tracks his DNA methylation patterns weekly
“I've been measuring my methylation patterns every week for the past couple years, so more than anyone out there.”
Johnson: Extreme Wealth Warps Relationships by Becoming a Third Entity
“Like it warps all of your relationships. It's like every, every person in your life now has, it's like you have three people in the relationship. It's like you, your money and the person.”
Johnson: Sperm Counts, Fertility, Birth Rates, and Sexual Activity Are All Falling
“You have on one side, sperm counts going down, fertility is going down, birth rates going down, sexual activity is going down like all these indicators of like, of humans having sex and You know, like having babies, they're all going down.”
Bryan Johnson takes NR in capsules, rejecting NAD IV infusions
“No, there's not good evidence. That's a good modality. I take it via capsule form. I take NR, yeah.”
Bryan Johnson: I still take roughly 100 supplements daily, mostly in a drink
“I took majority of those and put it into a drink. I was like, I still take basically a hundred pills a day. Just now they're in part of a drink. So it's easier to take. And so then four-year pill capsule form.”
Bryan Johnson: Ultimate goal is validation from 25th-century humans
“I want something very simple. I want the, those who exist in the 25th century, I want them to say, he got it. He got it. He got that moment right. He saw it.”
Johnson: High BPA levels correlate with substantially fewer eggs in women
“So a recent study showed that women with high levels of BPA produced substantially fewer eggs and ovulation. That contaminants reduces the body's production of eggs.”
Johnson: 'Don't die' is the foundational game played before capitalism or religion
“That's the zeroth step, is, you know, don't die is the most played game By every human, by every living being on every animal, every plant, every human, it's don't die every second of every day. And so it's played more than capitalism. It's played more than re…”
Johnson: Aim to be zero and create new games instead of competing
“Don't try to be number one. Try to be zero. And number one is like you're going for rank in a given game. You're trying to be other players. A zero is, this is like a different concept. Zero is principle thinking. You're trying to come up with a new idea, a ne…”
Johnson disregards his first five thoughts to let his brain situate itself
“I know with my thoughts, in any given situation, I will disregard the first Five or six thoughts I have on anything because I know my brain's like just trying to situate itself.”
Johnson: Blueprint aims to be the best health protocol and completely free
“We tried to basically make the best health protocol in human history, and then make the whole thing available for free for everybody.”
Bryan Johnson: Pause judgment on new ideas to prevent knee-jerk bias
“And I make a rule for myself that whenever I encounter a new idea, I try to set up an alert in my brain that says, alert, new idea has landed. And when a new idea lands, the rule is I can't say anything or think anything to form conclusions for some duration o…”
Bryan Johnson created distinct internal personas to manage his negative behaviors
“I built this off of the idea of the evening Brian concept where he overate and he couldn't control himself and that I separated myself into different versions of me.”
Bryan Johnson: People reject new ideas because they threaten their fundamental identity
“So if you're already geared up and say, I find that I'm valuable in society because I'm doing this heroic act. If you remove the underlying layer, it's no longer heroic and valuable. And so it removes all other identity. And so your knee-jerk response would be…”
Bryan Johnson: Questioning my religion was my most uncomfortable life experience
“And that is the most uncomfortable thing I had ever encountered in my life because Every single bit of my reality, my family and my children and my community and my identity and my ambitions, everything was built upon that thing.”