Dec 27, 2022 · 1h 53m · knowledge-project

Best of 2022: Conversations of the Year

Matthew Walker · 14m spoken Shane Parrish · 12m spoken Laurie Santos · 11m spoken Dr. David Sinclair · 9m spoken Kunal Shah · 9m spoken Diana Chapman · 8m spoken Dr. Andrew Huberman · 8m spoken Reid Hoffman · 7m spoken Sarah Jones Simmer · 7m spoken Alan Mulally · 6m spoken Marshall Goldsmith · 6m spoken
0:00 / 0:00

gold bands on the timeline = statements, start to end. Hover to read, click to jump. CC turns on captions

This annual retrospective compilation of The Knowledge Project features host Shane Parrish and world-class experts delivering actionable frameworks across psychology, leadership, neuroscience, decision-making, and biological longevity. The episode distills key insights to help listeners master their mindset, optimize physical health, and lead organizations with clarity.

How this conversation actually went

Every chapter scored 0–10 on four independent dynamics. Hover any point for the reasoning behind the score. Shane holds 11.6% of the talking time here. How this is scored →

Shane as informed peer 2.6 Guest teaching 4.7 Guest disagreement 0.6 Shane pushing back 0.6
05100:0020:0040:001:00:001:20:001:40:002:02–15:39 · Shane as informed peer 4/10 Lori Santos on Positive Psychology and Parenting for Resilience Shane Parrish offers his own conceptual reframing about gratitude and perspective, which Lori Santos validates and connects to negative visualization. The dynamic is highly collaborative with Santos delivering positive psychology research while Parrish actively synthesizes concepts.15:39–23:08 · Shane as informed peer 0/10 Alan Mulally on Collaborative Leadership and Culture by Design This excerpt consists entirely of Alan Mulally detailing his leadership philosophy and the Ford business review operating system. Parrish does not speak during the clip except in intro and outro framing.23:09–31:51 · Shane as informed peer 2/10 Marshall Goldsmith on Escaping the Achievement Trap Marshall Goldsmith delivers a strong critique of the Western achievement obsession and the fairy tale mentality of corporate goals. Parrish primarily asks an open guiding question allowing Goldsmith to explain process-driven focus.31:52–42:30 · Shane as informed peer 4/10 Diana Chapman on the Drama Triangle and Conscious Leadership Parrish checks his comprehension of Chapman's 100% responsibility framework and connects reactive behavior to an absence of reasoning. Chapman enthusiastically affirms Parrish's observations and elaborates on ego defense mechanisms.42:32–51:52 · Shane as informed peer 0/10 Dr. Andrew Huberman on Impulse Control and Neural Pathways Dr. Huberman provides an extended scientific monologue explaining basal ganglia circuitry, go versus no-go pathways, and personal protocols for impulse control. Parrish does not intervene during the explanation.51:52–1:00:32 · Shane as informed peer 2/10 Reid Hoffman on Principles for Fast and Simple Decisions Reid Hoffman explains decision frameworks including OODA loops, speed, simplicity, and reversibility. Parrish acts as an interviewer prompting deeper application of decision-making pedagogy.1:00:33–1:12:42 · Shane as informed peer 5/10 Kunal Shah on Core Human Motivations and Actionable Insights Parrish actively interjects to parallel Shah's pitch testing technique with switching conversation abstraction levels, and later compares Western and Asian consumer status psychology. Shah refines and expands on these distinctions with cultural economic examples.1:12:43–1:29:45 · Shane as informed peer 3/10 Matthew Walker on Sleep Optimization, Chronotypes, and Hygiene Matthew Walker explains circadian biology, chronotype misalignment, and counterintuitive sleep hygiene rules while actively engaging Parrish on his natural sleep schedule. Parrish contributes personal anecdotes and questions about unconventional practices.1:29:46–1:42:10 · Shane as informed peer 4/10 David Sinclair on Epigenetic Aging and Intermittent Fasting Parrish cites Sinclair's previous DVD scratch analogy and probes practical fasting boundaries, such as meal consolidation versus caloric deficits. Sinclair builds directly on Parrish's prompts with molecular biology and clinical research.1:42:11–1:51:28 · Shane as informed peer 2/10 Sarah Jones Simmer on Perspective, Purpose, and Overcoming Adversity Sarah Jones Simmer shares a personal narrative about navigating stage three cancer and a brain aneurysm during Bumble's IPO. Parrish provides supportive, empathetic prompts focused on life perspective.2:02–15:39 · Guest teaching 4/10 Lori Santos on Positive Psychology and Parenting for Resilience Shane Parrish offers his own conceptual reframing about gratitude and perspective, which Lori Santos validates and connects to negative visualization. The dynamic is highly collaborative with Santos delivering positive psychology research while Parrish actively synthesizes concepts.15:39–23:08 · Guest teaching 5/10 Alan Mulally on Collaborative Leadership and Culture by Design This excerpt consists entirely of Alan Mulally detailing his leadership philosophy and the Ford business review operating system. Parrish does not speak during the clip except in intro and outro framing.23:09–31:51 · Guest teaching 5/10 Marshall Goldsmith on Escaping the Achievement Trap Marshall Goldsmith delivers a strong critique of the Western achievement obsession and the fairy tale mentality of corporate goals. Parrish primarily asks an open guiding question allowing Goldsmith to explain process-driven focus.31:52–42:30 · Guest teaching 4/10 Diana Chapman on the Drama Triangle and Conscious Leadership Parrish checks his comprehension of Chapman's 100% responsibility framework and connects reactive behavior to an absence of reasoning. Chapman enthusiastically affirms Parrish's observations and elaborates on ego defense mechanisms.42:32–51:52 · Guest teaching 6/10 Dr. Andrew Huberman on Impulse Control and Neural Pathways Dr. Huberman provides an extended scientific monologue explaining basal ganglia circuitry, go versus no-go pathways, and personal protocols for impulse control. Parrish does not intervene during the explanation.51:52–1:00:32 · Guest teaching 5/10 Reid Hoffman on Principles for Fast and Simple Decisions Reid Hoffman explains decision frameworks including OODA loops, speed, simplicity, and reversibility. Parrish acts as an interviewer prompting deeper application of decision-making pedagogy.1:00:33–1:12:42 · Guest teaching 5/10 Kunal Shah on Core Human Motivations and Actionable Insights Parrish actively interjects to parallel Shah's pitch testing technique with switching conversation abstraction levels, and later compares Western and Asian consumer status psychology. Shah refines and expands on these distinctions with cultural economic examples.1:12:43–1:29:45 · Guest teaching 6/10 Matthew Walker on Sleep Optimization, Chronotypes, and Hygiene Matthew Walker explains circadian biology, chronotype misalignment, and counterintuitive sleep hygiene rules while actively engaging Parrish on his natural sleep schedule. Parrish contributes personal anecdotes and questions about unconventional practices.1:29:46–1:42:10 · Guest teaching 5/10 David Sinclair on Epigenetic Aging and Intermittent Fasting Parrish cites Sinclair's previous DVD scratch analogy and probes practical fasting boundaries, such as meal consolidation versus caloric deficits. Sinclair builds directly on Parrish's prompts with molecular biology and clinical research.1:42:11–1:51:28 · Guest teaching 2/10 Sarah Jones Simmer on Perspective, Purpose, and Overcoming Adversity Sarah Jones Simmer shares a personal narrative about navigating stage three cancer and a brain aneurysm during Bumble's IPO. Parrish provides supportive, empathetic prompts focused on life perspective.2:02–15:39 · Guest disagreement 0/10 Lori Santos on Positive Psychology and Parenting for Resilience Shane Parrish offers his own conceptual reframing about gratitude and perspective, which Lori Santos validates and connects to negative visualization. The dynamic is highly collaborative with Santos delivering positive psychology research while Parrish actively synthesizes concepts.15:39–23:08 · Guest disagreement 0/10 Alan Mulally on Collaborative Leadership and Culture by Design This excerpt consists entirely of Alan Mulally detailing his leadership philosophy and the Ford business review operating system. Parrish does not speak during the clip except in intro and outro framing.23:09–31:51 · Guest disagreement 2/10 Marshall Goldsmith on Escaping the Achievement Trap Marshall Goldsmith delivers a strong critique of the Western achievement obsession and the fairy tale mentality of corporate goals. Parrish primarily asks an open guiding question allowing Goldsmith to explain process-driven focus.31:52–42:30 · Guest disagreement 1/10 Diana Chapman on the Drama Triangle and Conscious Leadership Parrish checks his comprehension of Chapman's 100% responsibility framework and connects reactive behavior to an absence of reasoning. Chapman enthusiastically affirms Parrish's observations and elaborates on ego defense mechanisms.42:32–51:52 · Guest disagreement 1/10 Dr. Andrew Huberman on Impulse Control and Neural Pathways Dr. Huberman provides an extended scientific monologue explaining basal ganglia circuitry, go versus no-go pathways, and personal protocols for impulse control. Parrish does not intervene during the explanation.51:52–1:00:32 · Guest disagreement 0/10 Reid Hoffman on Principles for Fast and Simple Decisions Reid Hoffman explains decision frameworks including OODA loops, speed, simplicity, and reversibility. Parrish acts as an interviewer prompting deeper application of decision-making pedagogy.1:00:33–1:12:42 · Guest disagreement 2/10 Kunal Shah on Core Human Motivations and Actionable Insights Parrish actively interjects to parallel Shah's pitch testing technique with switching conversation abstraction levels, and later compares Western and Asian consumer status psychology. Shah refines and expands on these distinctions with cultural economic examples.1:12:43–1:29:45 · Guest disagreement 0/10 Matthew Walker on Sleep Optimization, Chronotypes, and Hygiene Matthew Walker explains circadian biology, chronotype misalignment, and counterintuitive sleep hygiene rules while actively engaging Parrish on his natural sleep schedule. Parrish contributes personal anecdotes and questions about unconventional practices.1:29:46–1:42:10 · Guest disagreement 0/10 David Sinclair on Epigenetic Aging and Intermittent Fasting Parrish cites Sinclair's previous DVD scratch analogy and probes practical fasting boundaries, such as meal consolidation versus caloric deficits. Sinclair builds directly on Parrish's prompts with molecular biology and clinical research.1:42:11–1:51:28 · Guest disagreement 0/10 Sarah Jones Simmer on Perspective, Purpose, and Overcoming Adversity Sarah Jones Simmer shares a personal narrative about navigating stage three cancer and a brain aneurysm during Bumble's IPO. Parrish provides supportive, empathetic prompts focused on life perspective.2:02–15:39 · Shane pushing back 1/10 Lori Santos on Positive Psychology and Parenting for Resilience Shane Parrish offers his own conceptual reframing about gratitude and perspective, which Lori Santos validates and connects to negative visualization. The dynamic is highly collaborative with Santos delivering positive psychology research while Parrish actively synthesizes concepts.15:39–23:08 · Shane pushing back 0/10 Alan Mulally on Collaborative Leadership and Culture by Design This excerpt consists entirely of Alan Mulally detailing his leadership philosophy and the Ford business review operating system. Parrish does not speak during the clip except in intro and outro framing.23:09–31:51 · Shane pushing back 0/10 Marshall Goldsmith on Escaping the Achievement Trap Marshall Goldsmith delivers a strong critique of the Western achievement obsession and the fairy tale mentality of corporate goals. Parrish primarily asks an open guiding question allowing Goldsmith to explain process-driven focus.31:52–42:30 · Shane pushing back 1/10 Diana Chapman on the Drama Triangle and Conscious Leadership Parrish checks his comprehension of Chapman's 100% responsibility framework and connects reactive behavior to an absence of reasoning. Chapman enthusiastically affirms Parrish's observations and elaborates on ego defense mechanisms.42:32–51:52 · Shane pushing back 0/10 Dr. Andrew Huberman on Impulse Control and Neural Pathways Dr. Huberman provides an extended scientific monologue explaining basal ganglia circuitry, go versus no-go pathways, and personal protocols for impulse control. Parrish does not intervene during the explanation.51:52–1:00:32 · Shane pushing back 0/10 Reid Hoffman on Principles for Fast and Simple Decisions Reid Hoffman explains decision frameworks including OODA loops, speed, simplicity, and reversibility. Parrish acts as an interviewer prompting deeper application of decision-making pedagogy.1:00:33–1:12:42 · Shane pushing back 3/10 Kunal Shah on Core Human Motivations and Actionable Insights Parrish actively interjects to parallel Shah's pitch testing technique with switching conversation abstraction levels, and later compares Western and Asian consumer status psychology. Shah refines and expands on these distinctions with cultural economic examples.1:12:43–1:29:45 · Shane pushing back 0/10 Matthew Walker on Sleep Optimization, Chronotypes, and Hygiene Matthew Walker explains circadian biology, chronotype misalignment, and counterintuitive sleep hygiene rules while actively engaging Parrish on his natural sleep schedule. Parrish contributes personal anecdotes and questions about unconventional practices.1:29:46–1:42:10 · Shane pushing back 1/10 David Sinclair on Epigenetic Aging and Intermittent Fasting Parrish cites Sinclair's previous DVD scratch analogy and probes practical fasting boundaries, such as meal consolidation versus caloric deficits. Sinclair builds directly on Parrish's prompts with molecular biology and clinical research.1:42:11–1:51:28 · Shane pushing back 0/10 Sarah Jones Simmer on Perspective, Purpose, and Overcoming Adversity Sarah Jones Simmer shares a personal narrative about navigating stage three cancer and a brain aneurysm during Bumble's IPO. Parrish provides supportive, empathetic prompts focused on life perspective.

speaking balance: gold is Shane, purple is the guest (3 minute bins)

0:00 · Shane 63.8% · guest 36.2%0:00 · Shane 63.8% · guest 36.2%3:00 · Shane 25.3% · guest 74.7%3:00 · Shane 25.3% · guest 74.7%6:00 · Shane 10.6% · guest 89.4%6:00 · Shane 10.6% · guest 89.4%9:00 · Shane 3.9% · guest 96.1%9:00 · Shane 3.9% · guest 96.1%12:00 · Shane 12.2% · guest 87.8%12:00 · Shane 12.2% · guest 87.8%15:00 · Shane 18% · guest 82%15:00 · Shane 18% · guest 82%18:00 · Shane 0% · guest 100%18:00 · Shane 0% · guest 100%21:00 · Shane 18.6% · guest 81.4%21:00 · Shane 18.6% · guest 81.4%24:00 · Shane 0% · guest 100%24:00 · Shane 0% · guest 100%27:00 · Shane 0% · guest 100%27:00 · Shane 0% · guest 100%30:00 · Shane 21.4% · guest 78.6%30:00 · Shane 21.4% · guest 78.6%33:00 · Shane 14.7% · guest 85.3%33:00 · Shane 14.7% · guest 85.3%36:00 · Shane 0% · guest 100%36:00 · Shane 0% · guest 100%39:00 · Shane 19.5% · guest 80.5%39:00 · Shane 19.5% · guest 80.5%42:00 · Shane 19.3% · guest 80.7%42:00 · Shane 19.3% · guest 80.7%45:00 · Shane 0% · guest 100%45:00 · Shane 0% · guest 100%48:00 · Shane 0% · guest 100%48:00 · Shane 0% · guest 100%51:00 · Shane 16.5% · guest 83.5%51:00 · Shane 16.5% · guest 83.5%54:00 · Shane 5.4% · guest 94.6%54:00 · Shane 5.4% · guest 94.6%57:00 · Shane 0% · guest 100%57:00 · Shane 0% · guest 100%1:00:00 · Shane 28.9% · guest 71.1%1:00:00 · Shane 28.9% · guest 71.1%1:03:00 · Shane 3.9% · guest 96.1%1:03:00 · Shane 3.9% · guest 96.1%1:06:00 · Shane 0% · guest 100%1:06:00 · Shane 0% · guest 100%1:09:00 · Shane 10.5% · guest 89.5%1:09:00 · Shane 10.5% · guest 89.5%1:12:00 · Shane 20.1% · guest 79.9%1:12:00 · Shane 20.1% · guest 79.9%1:15:00 · Shane 6.1% · guest 93.9%1:15:00 · Shane 6.1% · guest 93.9%1:18:00 · Shane 4.2% · guest 95.8%1:18:00 · Shane 4.2% · guest 95.8%1:21:00 · Shane 0% · guest 100%1:21:00 · Shane 0% · guest 100%1:24:00 · Shane 3.1% · guest 96.9%1:24:00 · Shane 3.1% · guest 96.9%1:27:00 · Shane 10.5% · guest 89.5%1:27:00 · Shane 10.5% · guest 89.5%1:30:00 · Shane 8.6% · guest 91.4%1:30:00 · Shane 8.6% · guest 91.4%1:33:00 · Shane 25% · guest 75%1:33:00 · Shane 25% · guest 75%1:36:00 · Shane 13.8% · guest 86.2%1:36:00 · Shane 13.8% · guest 86.2%1:39:00 · Shane 6.7% · guest 93.3%1:39:00 · Shane 6.7% · guest 93.3%1:42:00 · Shane 23.9% · guest 76.1%1:42:00 · Shane 23.9% · guest 76.1%1:45:00 · Shane 18.7% · guest 81.3%1:45:00 · Shane 18.7% · guest 81.3%1:48:00 · Shane 0% · guest 100%1:48:00 · Shane 0% · guest 100%1:51:00 · Shane 27.6% · guest 72.4%1:51:00 · Shane 27.6% · guest 72.4%
Sharpest disagreement ▶ 25:15 Marshall Goldsmith Dismissing Achievement Culture

Marshall Goldsmith emphatically attacks conventional Western self-help dogmas around achievement, calling outcomes-based self-worth a fool's game and fairy tale.

Hardest push from Shane ▶ 1:09:01 Shane Parrish Challenging Western Status Framing

Shane Parrish pushes back on Kunal Shah's premise about regional status differences by asserting that Western consumers also buy status, just framed around treating oneself.

Biggest teaching moment ▶ 1:18:00 Matthew Walker Diagnosing Chronotype Mismatch

Matthew Walker clearly educates the listener and host by explaining how perceived sleep onset insomnia is often an innate biological chronotype mismatch rather than a clinical disorder.

Shane holds their own ▶ 1:01:31 Shane Parrish Paralleling Abstraction Levels

Shane Parrish interrupts Kunal Shah to demonstrate domain expertise, offering a complementary mental model about shifting conversational levels of abstraction when evaluating founders.

the scores for every segment, with the reasoning behind each
ChapterTopicShane as informed peerGuest teachingGuest disagreementShane pushing backWhy
Lori Santos on Positive Psychology and Parenting for Resilience 4401 Shane Parrish offers his own conceptual reframing about gratitude and perspective, which Lori Santos validates and connects to negative visualization. The dynamic is highly collaborative with Santos delivering positive psychology research while Parrish actively synthesizes concepts.
Alan Mulally on Collaborative Leadership and Culture by Design 0500 This excerpt consists entirely of Alan Mulally detailing his leadership philosophy and the Ford business review operating system. Parrish does not speak during the clip except in intro and outro framing.
Marshall Goldsmith on Escaping the Achievement Trap 2520 Marshall Goldsmith delivers a strong critique of the Western achievement obsession and the fairy tale mentality of corporate goals. Parrish primarily asks an open guiding question allowing Goldsmith to explain process-driven focus.
Diana Chapman on the Drama Triangle and Conscious Leadership 4411 Parrish checks his comprehension of Chapman's 100% responsibility framework and connects reactive behavior to an absence of reasoning. Chapman enthusiastically affirms Parrish's observations and elaborates on ego defense mechanisms.
Dr. Andrew Huberman on Impulse Control and Neural Pathways 0610 Dr. Huberman provides an extended scientific monologue explaining basal ganglia circuitry, go versus no-go pathways, and personal protocols for impulse control. Parrish does not intervene during the explanation.
Reid Hoffman on Principles for Fast and Simple Decisions 2500 Reid Hoffman explains decision frameworks including OODA loops, speed, simplicity, and reversibility. Parrish acts as an interviewer prompting deeper application of decision-making pedagogy.
Kunal Shah on Core Human Motivations and Actionable Insights 5523 Parrish actively interjects to parallel Shah's pitch testing technique with switching conversation abstraction levels, and later compares Western and Asian consumer status psychology. Shah refines and expands on these distinctions with cultural economic examples.
Matthew Walker on Sleep Optimization, Chronotypes, and Hygiene 3600 Matthew Walker explains circadian biology, chronotype misalignment, and counterintuitive sleep hygiene rules while actively engaging Parrish on his natural sleep schedule. Parrish contributes personal anecdotes and questions about unconventional practices.
David Sinclair on Epigenetic Aging and Intermittent Fasting 4501 Parrish cites Sinclair's previous DVD scratch analogy and probes practical fasting boundaries, such as meal consolidation versus caloric deficits. Sinclair builds directly on Parrish's prompts with molecular biology and clinical research.
Sarah Jones Simmer on Perspective, Purpose, and Overcoming Adversity 2200 Sarah Jones Simmer shares a personal narrative about navigating stage three cancer and a brain aneurysm during Bumble's IPO. Parrish provides supportive, empathetic prompts focused on life perspective.

Statements from this episode (26)

Assertion Supported
Santos: Writing Gratitude Lists Significantly Boosts Well-Being Within Two Weeks
“There's evidence that in as little as two weeks, the simple act of writing three to five things you're grateful for down on a piece of paper can improve your well-being, like significantly improve your well-being.”
Laurie Santos Dec 27, 2022 ▶ 2:59
Assertion Supported
Santos: Sending a Thank-You Letter Boosts Well-Being for Over a Month
“There's also evidence that expressing gratitude to other people, like writing a, you know, a detailed thank you note to someone that you've always wanted to thank but never gotten a chance to. The act of doing that, at least in Marty Seligman and others' data,…”
Laurie Santos Dec 27, 2022 ▶ 3:09
Assertion Supported
Santos: Genetics Accounts for Only 30% to 40% of Happiness Variance
“You know, even the heritability of happiness is, is lower than you might expect. You know, estimates kind of vary, but it's probably around, you know, 40%, 30%. Like, it's not that all the variants and the happy people that you see out there in the world is li…”
Laurie Santos Dec 27, 2022 ▶ 7:42
Assertion Partly supported
Santos: Over-Intervention by Parents Causes Children to Give Up Faster
“What she finds is that when you give kids a very different puzzle later on, kids who've had that taking over condition, where the parents give the answer, give up much more quickly. And if you find ways to survey them about what they believe, like, they probab…”
Laurie Santos Dec 27, 2022 ▶ 11:30
Insight
Santos: Children Mirror Their Parents' Anxiety Through Emotional Contagion
“I think one thing that's useful for parents to remember is about the science of emotional contagion, that like, you know, we naturally catch other people's emotions. If you're embodying calm, and this is going to be fine, and everything's okay, then kids are g…”
Laurie Santos Dec 27, 2022 ▶ 14:24
Disclosure
Mulally: Boeing 777 leadership team included all internal and external stakeholders
“So when you're designing the airplane, we include not only the airlines, but we include, of course, all the employees, all the suppliers, all the certification agencies around the world, all the cities in which the airplane is going to be used, and all of the …”
Alan Mulally Dec 27, 2022 ▶ 17:48
Insight
Mulally: Leaders should celebrate red status reports instead of treating them as failures
“When you share these things, I mean, many people, many leaders, if they have a red item, first of all, that embarrasses them, they think they're not doing their job. As opposed to that red item is a gem. We, I clap when you have a red because you're not the, y…”
Alan Mulally Dec 27, 2022 ▶ 20:43
Insight
Mulally: Organizations must have zero tolerance for violating operating processes and behavioral norms
“Now, there's one corollary to that, Shane, that's really important, and that is zero tolerance for violating this process of working, the business plan review, the creating value roadmap, including everybody all stakeholders on the leadership team. Zero tolera…”
Alan Mulally Dec 27, 2022 ▶ 22:27
Insight
Goldsmith: Conditioning self-worth on achievement results is a fool's game
“Never make your value as a human being conditioned on the results of what you're trying to achieve. Never do that. It's a fool's game. It is a fool's game for two reasons. One, you don't control the outcomes. There are a million variables impacting anything we…”
Marshall Goldsmith Dec 27, 2022 ▶ 25:35
Insight
Diana Chapman: Playing the hero requires keeping others disempowered as victims
“In order to hero, you need victims. And then that means you are requiring people to be disempowered so you can hero. And that's not such a, you know, that's how we're just going to create more battles amongst us.”
Diana Chapman Dec 27, 2022 ▶ 39:04
Insight
Diana Chapman: Failing to source self-approval leads to controlling behavior and suffering
“If I can't source all the approval I've ever wanted, I'm gonna then be out in the world trying to control my approval, and that's gonna cause a decent amount of suffering for me, and maybe for others too.”
Diana Chapman Dec 27, 2022 ▶ 42:07
Insight
Huberman: Practicing impulse suppression in one task strengthens general self-control
“The thing to understand about neural circuitry is that it's generic. It doesn't, it's not designed so that you have a strong no-go response just to picking up your phone. It actually carries over to multiple other things. And this is also true of the go circui…”
Dr. Andrew Huberman Dec 27, 2022 ▶ 46:35
Opinion
Hoffman: Silicon Valley and China are the only places mastering fast OODA loops
“When I kind of go through the entire world, there's basically two places that embody this fighter pilot terminology called an OODA loop, observe, orient, decide, act. It's how fast you make these decisions through this kind of the, this framework, both as indi…”
Reid Hoffman Dec 27, 2022 ▶ 53:21
Insight
Hoffman: Simple plans are the only ones that spread without distortion
“Simple plans are all that work. Simple plans are all that kind of, you know, simple things are the thing that can most easily spread without distortion within an organization.”
Reid Hoffman Dec 27, 2022 ▶ 55:17
Insight
Shah: Products that cannot be simply explained at dinner face high CAC
“If you cannot distill your idea to a transmissible conversation at dinner, it's not going to spread. And things that don't spread will have a huge cack because nobody really understands what the hell are you doing?”
Kunal Shah Dec 27, 2022 ▶ 1:02:47
Insight
Shah: Insights are the smallest actionable units of truth driving business success
“I believe that insight is the smallest unit of truth that is actionable, and therefore people who operate in the currency of insights tend to be generally more successful, at least in business.”
Kunal Shah Dec 27, 2022 ▶ 1:05:28
Insight
Shah: Improving status for mating and progeny is the core human motivation
“The core human game is to constantly improve our social status so that we improve our mating success or our success of our progeny.”
Kunal Shah Dec 27, 2022 ▶ 1:09:36
Assertion Supported
Shah: India is the world's largest recipient of inward remittances
“India is the largest market which sends money back to India amongst all markets that does remittance. Indians remit the highest amount of money back to their family. Then it comes to Mexico and others.”
Kunal Shah Dec 27, 2022 ▶ 1:11:13
Assertion Supported
Walker: Average human endogenous circadian rhythm is roughly 24 hours 11 minutes
“It runs a little bit longer than 24 hours, it turns out. It's about 24 hours and I think 11 minutes for the average human adult we've calculated it as.”
Matthew Walker Dec 27, 2022 ▶ 1:15:42
Insight
Walker: After a bad night of sleep, do nothing to compensate
“If you've had a bad night of sleep, here is my following best advice. Do nothing. And what I mean by that is, after a bad night of sleep, firstly, don't try to sleep it off by waking up any later than is natural. Don't sort of say, I'm going to then sleep in f…”
Matthew Walker Dec 27, 2022 ▶ 1:20:21
Opinion
Walker: Sleep Stories saved Calm and drove its near-billion-dollar valuation
“It certainly saved Calm, and it gave them a, you know, I think almost a billion dollar valuation. What saved them was Sleep Stories”
Matthew Walker Dec 27, 2022 ▶ 1:24:26
Assertion Contradicted
Walker: Counting sheep actually causes people to take longer to fall asleep
“What she found was that not only did counting sheep not make you fall asleep any faster, it actually made people take longer to fall asleep.”
Matthew Walker Dec 27, 2022 ▶ 1:26:39
Assertion Supported
Sinclair: Sirtuin Gene Therapy Extends Mouse Lifespan in Lab Studies
“And there are seven of these epigenetic regulators, the things that prevent the scratches, and we can turn them on With gene therapy. In mice, we do this, and if you do it in the brain of a mouse, they'll live longer. Do it in the body, they can live longer.”
Dr. David Sinclair Dec 27, 2022 ▶ 1:35:08
Insight
Sinclair: Fasting at Least 14 Hours Triggers Measurable Metabolic Benefits
“Well, it seems to be a rule that if you fast at least 14 hours, you'll have a lot of health benefits, better metabolic stability, lower blood sugar levels, better cholesterol, these kind of things kick in.”
Dr. David Sinclair Dec 27, 2022 ▶ 1:38:40
Assertion Partly supported
Sinclair: Time-Restricted Feeding Extended Mouse Lifespan by 30% Regardless of Diet
“And there's a very famous study that was done by a colleague of mine, Rafael de Cabo at the NIH in Bethesda, and he made three different types of diets for mice. One that had a lot of protein, the other had carbs, the other had fat, and he thought he would fin…”
Dr. David Sinclair Dec 27, 2022 ▶ 1:41:31
Insight
Simmer: A Five-Year Horizon Mental Model Optimizes Daily Life Prioritization
“There's something very special about that five year timeframe. You know, if you had 30 days, you would change everything. And on the other end of the spectrum, all of us live right now, like we've got infinity in front of us. But what if you have five years? W…”
Sarah Jones Simmer Dec 27, 2022 ▶ 1:49:08
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