Rapamycin
product on 4 shows · 9 statements across 6 episodes · said 18 times in 7 episodes since 2018
the a16z Podcast 9 
WTF is with Nikhil Kamath 6 
My First Million 2 
the Knowledge Project 1
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the a16z Podcast 9WTF is with Nikhil Kamath 6My First Million 2the Knowledge Project 1
2025 7 mentions in 2 episodes 4 per episode
2022 3 mentions in 2 episodes 2 per episode
2019 4 mentions in 2 episodes 2 per episode
2018 4 mentions in 1 episode
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9 statements about Rapamycin, every show
Bryan Johnson: Stopped rapamycin due to lipid spikes and elevated heart rate
“I mean, it's the side effect profile. It's the, it messes with lipids. It messes with blood glucose. I had small tissue infection soft tissue infections. It raised my resting heart rate. And so we knew we had these side effects, but we just wondered, like, whe…”
JC: Rapamycin Provides No Added Benefit If You Exercise and Eat Protein
“If somebody is not working out and not eating enough amount of protein, they can benefit from taking rapamycin. But if you are working out and you feel taking adequate amount of protein, no difference.”
Rose, Jack Dorsey, and Brian Armstrong are funding dog longevity trials
“Myself and Jack Dorsey and Brian from Coinbase and a few others all have been putting money into funding studies at the University of Washington to really prove this out in dogs and canines, and then eventually move it into human trials.”
Sinclair: Rapamycin extends animal lifespan even when started late in life
“There are animal studies you can, I could point to that show that you can have, affect this mTOR pathway with a drug called rapamycin that extends their lifespan, even if they're the equivalent of 70 years old.”
Gil: Rapamycin and metformin extend organism lifespans by 5% to 30%
“There's at least two FDA approved drugs that in multiple organisms will extend lifespan between five and 30%. One of them is rapamycin, which in mice, for example, extend lifespan 10 to 30%, and it also extends lifespan And flies and worms and other organisms.…”
Fortney: Rapamycin extended middle-aged mouse lifespan by 30 percent
“Even though they've only tested 30, there's already been one success rapamycin that came out of that, which is a very exciting discovery. Basically, the first molecule that came out of this large-scale program, they started to feed it to mice at middle age, an…”
Rapamycin reproducibly extends middle-aged mouse lifespan by 14% on average
“And this is, I would consider this to be one of the first drugs shown to reproducibly extend mouse lifespan. It's a very solid result. It's been done over and over again, and basically they gave this drug to mice starting from middle age, and it boosted their …”
Phase IIb trial shows rapamycin reduces elderly respiratory infections by 30%
“And they just published their Phase IIb data this summer, showing that Rapamycin can improve certain aspects of immunosenescence. So as you get older, your immune system doesn't work quite so well, and people who took rapamycin had 30% fewer respiratory infect…”
Current longevity clinical trials could add 10 to 20 healthy years
“Three different therapies are already in the clinic today. So as I mentioned, there are drugs targeting senescence, metformin, and there are drugs targeting rapamycin being tested in clinical trials now. And I think that could already add 10 to 20 years of hea…”