Peptides
topic on 8 shows · 16 statements across 12 episodes
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16 statements about Peptides, every show
Adelman: Longevity, Peptides, and Stem Cells Will Transform People's Lives
“My next frontier that I'm really getting involved in is, like, longevity, ok? Peptides, stem cells, all of that. Like, I think that is the wave of the future. Like, I think that is gonna change the scope of people's lives.”
Sam Lessin: Peptides Won't Get Insurance Coverage Anytime Soon
“I don't think they can be covered by insurance anytime soon. So like that really cuts the market way, way, way down. Like if you don't have payers involved, like GLP ones, it's much harder to make huge businesses out of it.”
Prasad: Global drug development pipeline is shifting from small molecules to biologics
“Pipeline used to be largely small molecules. It's now shifting to large molecules in biologics and peptides, and also another class of compounds called oligonucleotides.”
Hims & Hers will not be first to market in peptides
“You won't see us be first to market in this category. You'll see us when we launch it, feel extremely confident in the clinical protocols, extremely confident in the guardrails, make sure that the supply chain and the quality is done to a level we are, you kno…”
Shkreli: Peptide craze is driven by psychological issues and institutional distrust
“I'm very concerned about the peptide craze. I think it comes mostly out of psychological issues which we'll discuss. The need for identity, control distrust of institutions, all kinds of things like that are leading to what we're seeing today.”
Marchione: Peptides are more viable due to normalization of injections and AI
“I also think as a modality, peptides are one that are more interesting than before, now that injecting is normal. Now the wellness and optimization is normal, not just treating disease, and now that we have AI for things like computational discovery.”
Shkreli: Pharma avoids peptides as the worst of both worlds
“And in fact, in pharma, you try to avoid peptides because of their inherent weaknesses. You go for small molecules or Really large molecules like antibodies. Peptides are sort of the worst of both worlds.”
Marchione: Under-researched peptide classes might change the world
“And we've seen one category of peptides GLP-ONE's already changed the world, and my contention is that there are other categories of peptides that are under-researched, but have really interesting kind of clinical vignettes that might change the world going fo…”
Shkreli: Gray-market peptide users are mostly wealthy people in SF and NY
“The people that are take peptides and have these peptide stacks are mostly people in SF, maybe New York. They're very wealthy people. They don't know what the rest of the world looks like. Nobody else in middle, middle America is excited to do this.”
Huberman: People should not inject peptides labeled for research purposes only
“I do not think anyone should inject peptides that are labeled as for research purposes only because even if it says 99% purity, the one percent is likely to be something called LPS, lipopolysaccharide, which can cause inflammation. It's not a good thing to be …”
Bryan Johnson notes many popular peptides have zero human clinical data
“Some peptides have done the clinical work, like there's hepatitis, but then there's a whole bunch of the class of peptides that we have no human data on.”
Demand for Smaller Protein Modalities Is Driven by Manufacturing Ease
“There's a general pattern. I think in a, in trying to design things that are smaller, you know, like it's easier to manufacture. At the same time, like that comes with like potentially other challenges, like maybe a little bit less selectivity than like, if yo…”
Mares: Non-patentable peptides will be exceptionally disruptive to pharma
“Oh man, I think peptides are going to be so disruptive to our current healthcare system. You know, I think that if you look at peptides there needs to be way more research. I'm like, not totally yet a peptide believer. But there needs to be way more research, …”
Huberman: Peptides should not be relegated to gray-market gym testing
“It's my opinion that every single peptide, not just GLP-I, every single peptide shouldn't be getting tested in the gray market of, like, gyms and, like, biohacking. That's, frankly, that's bullshit.”
Dr. Moore: I used GLP-1s to address stress-induced weight gain
“Even with my best intentions at 50 years old, my metabolic health was starting to become compromised because of chronic stress. There's not, you know, there's not much I can do outside. I'm doing the gym. I'm doing the food. I'm doing all the things. And I was…”