Metformin
product on 9 shows · 9 statements across 8 episodes · said 16 times in 11 episodes since 2018
My First Million 6 
the a16z Podcast 6 
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We Live to Build 1 
No Priors 1 
TBPN 1 
the Knowledge Project 
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the a16z Podcast 6My First Million 6We Live to Build 1No Priors 1Acquired 1TBPN 1
2026 1 mention in 1 episode
2025 1 mention in 1 episode
2024 4 mentions in 3 episodes 1 per episode
2023 3 mentions in 2 episodes 2 per episode
2022 1 mention in 1 episode
2019 2 mentions in 2 episodes 1 per episode
2018 4 mentions in 1 episode
every mention on every show, scene by scene, with the transcript →
9 statements about Metformin, every show
Belmonte: Metformin increases cognitive abilities and lifespan in monkeys
“For instance, I just finished, it's not, I think I can say that tomorrow, there will be just one of these molecules that diabetic people take, metformin, to lower down their glucose. They can reprogram the cells so that all the cognitive functions are not just…”
Sinclair: Diabetics on Metformin Outlive Healthy Non-Diabetics
“By looking at type two diabetics, and there's a stunning, stunning fact, that type two diabetics that would normally have a short lifespan, when they take metformin, typically at two grams a day, I'm on one gram a day, by the way, they actually have less disea…”
Girard: CMS Trial Found Lifestyle Program Outperformed Metformin
“It's based on clinical research the YMCA conducted with a big CMS innovation grant where they enrolled 3000 patients into a clinical trial, and they wanted to figure out if a drug called metformin was more effective than just making diet and lifestyle improvem…”
Gil: Rapamycin and metformin extend organism lifespans by 5% to 30%
“There's at least two FDA approved drugs that in multiple organisms will extend lifespan between five and 30%. One of them is rapamycin, which in mice, for example, extend lifespan 10 to 30%, and it also extends lifespan And flies and worms and other organisms.…”
Sinclair: Metformin and NAD boosters reduced calculated biological age from 57 to 31
“I took metformin, Kristen mentioned, which is a diabetes drug. I took another molecule that we've worked on called, it raises NAD, we call them NAD boosters, and I saw that my bio-age, according to this algorithm, went down to 31.4 from 57 point something, and…”
Fortney: Small molecule longevity drugs will likely emerge first
“I guess I'm expecting small molecules to come first because that's what pharma is used to. You know, that's what the, we have all the models to make that work. And the space of chemicals has been so unexplored. So I think there are going to be other repomycins…”
Retrospective study shows diabetics taking metformin have lower cancer rates
“So metformin is a first-line therapy for diabetes. Millions of people have been taking it for decades, and there was a paper that came out a few years ago where they looked retrospectively and saw that, hey, those diabetics that were taking metformin for decad…”
Current longevity clinical trials could add 10 to 20 healthy years
“Three different therapies are already in the clinic today. So as I mentioned, there are drugs targeting senescence, metformin, and there are drugs targeting rapamycin being tested in clinical trials now. And I think that could already add 10 to 20 years of hea…”
Pande: Omada's digital therapy demonstrates greater diabetes efficacy than metformin
“AMADA has a behavioral therapy, which is in a sense similar to areas like cognitive behavioral therapy, or CBT, derived from the CDC's Diabetes Prevention Program. And AMADA can demonstrate efficacy that actually exceeds that of metformin.”