Metformin

also referred to as: metformins

6 statements across 5 episodes · 6 bullish · 0 bearish · 4 people on the record · first statement Jan 11, 2018 by Vijay Pande · said 6 times in 3 episodes since 2018 · across every show →

Mentions by year

brought up most by Kristen Fortney (5), Elad Gil (1)

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00214220182019episodesmentions per episode
2019 2 mentions in 2 episodes 1 per episode
2018 4 mentions in 1 episode

every mention, scene by scene, with the transcript →

Everything said about Metformin, oldest first

Jan 11, 2018 positive
Assertion Contradicted
Pande: Omada's digital therapy demonstrates greater diabetes efficacy than metformin
“AMADA has a behavioral therapy, which is in a sense similar to areas like cognitive behavioral therapy, or CBT, derived from the CDC's Diabetes Prevention Program. And AMADA can demonstrate efficacy that actually exceeds that of metformin.”
Vijay Pande Jan 11, 2018 ▶ 17:21 When Biology Moves to Engineering
Dec 23, 2018 bullish
Prediction Not checkable as stated
Current longevity clinical trials could add 10 to 20 healthy years
“Three different therapies are already in the clinic today. So as I mentioned, there are drugs targeting senescence, metformin, and there are drugs targeting rapamycin being tested in clinical trials now. And I think that could already add 10 to 20 years of hea…”
Kristen Fortney Dec 23, 2018 ▶ 10:28 Extending Human Lifespan
Dec 23, 2018 positive
Assertion Supported
Retrospective study shows diabetics taking metformin have lower cancer rates
“So metformin is a first-line therapy for diabetes. Millions of people have been taking it for decades, and there was a paper that came out a few years ago where they looked retrospectively and saw that, hey, those diabetics that were taking metformin for decad…”
Kristen Fortney Dec 23, 2018 ▶ 9:52 Extending Human Lifespan
Jan 2, 2019 bullish
Prediction Didn’t hold up
Fortney: Small molecule longevity drugs will likely emerge first
“I guess I'm expecting small molecules to come first because that's what pharma is used to. You know, that's what the, we have all the models to make that work. And the space of chemicals has been so unexplored. So I think there are going to be other repomycins…”
Kristen Fortney Jan 2, 2019 ▶ 24:19 a16z Podcast | The Science Of Extending Life
Jan 2, 2019 positive
Disclosure
Sinclair: Metformin and NAD boosters reduced calculated biological age from 57 to 31
“I took metformin, Kristen mentioned, which is a diabetes drug. I took another molecule that we've worked on called, it raises NAD, we call them NAD boosters, and I saw that my bio-age, according to this algorithm, went down to 31.4 from 57 point something, and…”
David Sinclair Jan 2, 2019 ▶ 16:38 a16z Podcast | How to Live Longer and Better
Jan 2, 2019 positive
Assertion Partly supported
Gil: Rapamycin and metformin extend organism lifespans by 5% to 30%
“There's at least two FDA approved drugs that in multiple organisms will extend lifespan between five and 30%. One of them is rapamycin, which in mice, for example, extend lifespan 10 to 30%, and it also extends lifespan And flies and worms and other organisms.…”
Elad Gil Jan 2, 2019 ▶ 30:53 a16z Podcast | High Growth in Companies (and Tech)
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