David Sinclair

person on 8 shows · 15 statements across 5 episodes · said 26 times in 12 episodes since 2020

the Knowledge Project 12 My First Million 6 All-In 3 WTF is with Nikhil Kamath 1 Top Founders 1 the a16z Podcast 1 Big Technology 1 TBPN 1

On the record as a speaker too: David Sinclair across every show, appearances and statements → this page counts the times other people say the name.

Mentions by year, every show

tap a year for its mentions
0082154202020212022202320242025episodesmentions
024202020212022202320242025episodes it came up in
002244202020212022202320242025episodesmentions per episode

the Knowledge Project 12My First Million 6All-In 3Top Founders 1the a16z Podcast 1Big Technology 1TBPN 1WTF is with Nikhil Kamath 1

2025 1 mention in 1 episode
2024 2 mentions in 2 episodes 1 per episode
2023 1 mention in 1 episode
2022 12 mentions in 4 episodes 3 per episode
2021 8 mentions in 2 episodes 4 per episode
2020 2 mentions in 2 episodes 1 per episode

every mention on every show, scene by scene, with the transcript →

15 statements about David Sinclair, every show

ALL-IN Assertion Supported
Friedberg: David Sinclair sold a company to GSK for $720M on failed resveratrol claims
“Years ago he sold a company to GSK saying resveratrol would reverse aging and, you know, he made seven hundred twenty million dollars on that and it didn't end up working”
David Friedberg Feb 28, 2026 ▶ 1:05:29 Software Stocks Implode, Claude's Hit List, State of the Union Reactions, Trump's Tariff Pivot
TBPN Prediction Not checkable as stated
AI Specialists Will Give Average Users Better Longevity Care Than Elite Clinics
“It's going to be really incredible when the average person with their 10 dollar a month or a ring can get Even better care from this team of digital specialists than some, you know, public company CEO that's using David Sinclair's like, you know, longevity pro…”
Jordi Hays Nov 6, 2024 ▶ 1:26:34 Trump's Secret Career (ep7)
BIG TECHNOLOGY Prediction Open · timeframe Jul 2044
Diamandis: Longevity Escape Velocity Will Be Reached in About 20 Years
“Ray Kurzweil's prediction is 2030, which is insanely close, right? Why? It's because AI is going to help us understand why we age, how to slow it, how to stop it, how to reverse it. George Church puts it at some 15 years out. David Sinclair is in that same are…”
Peter Diamandis Jul 29, 2024 ▶ 43:11 Peter Diamandis — Embracing AI, Befriending Elon, And Living Forever
KNOWLEDGE PROJECT Assertion Supported
Sinclair: Sirtuin Gene Therapy Extends Lifespan in Mice
“In mice, we do this, and if you do it in the brain of a mouse, they'll live longer. Do it in the body. They can live longer, but we can't genetically modify ourselves.”
Dr. David Sinclair May 3, 2022 ▶ 10:40 David Sinclair: Reversing the Aging Process
KNOWLEDGE PROJECT Assertion Partly supported
Sinclair: Olive Oil and Red Wine Compounds Activate Sirtuins to Improve Health
“And there are actually chemicals within those foods of a Mediterranean diet in olive oil and red wine. That we found in my lab to activate these sirtuins and probably also slow down the clock, but they certainly improve health.”
Dr. David Sinclair May 3, 2022 ▶ 11:49 David Sinclair: Reversing the Aging Process
KNOWLEDGE PROJECT Assertion Not checkable as stated
Sinclair: Research Shows Interventions Can Make an 80-Year-Old Biologically 60
“We're keeping animals and increasingly we're showing with people that you can keep them younger for longer so that when you're 80, you can actually be 60.”
Dr. David Sinclair May 3, 2022 ▶ 12:11 David Sinclair: Reversing the Aging Process
KNOWLEDGE PROJECT Assertion Not checkable as stated
Sinclair: NMN Supplementation Has Prevented Jet Lag for a Decade
“I haven't had jet lag for a decade because I've been able to modulate my own body clock by using these chemicals, which as I mentioned are activating sirtuins and controlling the clock.”
Dr. David Sinclair May 3, 2022 ▶ 41:36 David Sinclair: Reversing the Aging Process
KNOWLEDGE PROJECT Assertion Supported
Sinclair: Research Restored Eyesight and Reversed Aging in Mice
“About a year ago, we published that we could reverse the age of an animal. And we restored eyesight to a blind old mouse and cure glaucoma in that animal.”
Dr. David Sinclair May 3, 2022 ▶ 1:10:48 David Sinclair: Reversing the Aging Process
KNOWLEDGE PROJECT Prediction Didn’t hold up
Sinclair: Team May Reverse Aging in Humans Within 18 Months
“In Canada, we have a non-human primate study for safety to see how that goes, and within the next 18 months, if all goes well, we will be reversing aging in a human, if all goes well.”
Dr. David Sinclair May 3, 2022 ▶ 1:11:01 David Sinclair: Reversing the Aging Process
Sinclair: Reversing Biological Age Will Eliminate Alzheimer's and Cancer
“Truly reset the age of the body and diseases of aging, like Alzheimer's and heart disease, even cancer will go away if we become young again.”
Dr. David Sinclair May 3, 2022 ▶ 1:11:27 David Sinclair: Reversing the Aging Process
a16z Prediction Not checkable as stated
Sinclair: Longevity tools will extend human lifespan by 5 to 15 years
“And those three combined, I think, are going to dramatically increase human health span and lifespan by somewhere between five and 15 years in our lifetimes.”
David Sinclair Jan 2, 2019 ▶ 4:17 a16z Podcast | How to Live Longer and Better
a16z Disclosure
Sinclair: Companies he advises are running anti-aging human trials
“A couple of companies that I work with have been doing trials for a number of years now, and they seem to be working as advertised, but it's pretty hard to actually show that they're reversing aging. So we're going off to particular diseases.”
David Sinclair Jan 2, 2019 ▶ 7:36 a16z Podcast | How to Live Longer and Better
a16z Prediction Not checkable as stated
Sinclair: Epigenetic reprogramming could enable five-year biological age resets
“There is actually evidence in a mouse that you can reverse some of those so-called epigenetic analog changes with aging, and that's truly the next frontier in my view, because that really could lead to true Aging reset, and you just go to the doctor every five…”
David Sinclair Jan 2, 2019 ▶ 8:38 a16z Podcast | How to Live Longer and Better
a16z Assertion Supported
Sinclair: A 10% cancer reduction saves the U.S. $3-4 trillion
“The economists have calculated that just reducing one major disease, let's say cancer, by just 10%, The U.S. Would save about three, four trillion dollars in the long run.”
David Sinclair Jan 2, 2019 ▶ 12:25 a16z Podcast | How to Live Longer and Better
a16z Disclosure
Sinclair: Metformin and NAD boosters reduced calculated biological age from 57 to 31
“I took metformin, Kristen mentioned, which is a diabetes drug. I took another molecule that we've worked on called, it raises NAD, we call them NAD boosters, and I saw that my bio-age, according to this algorithm, went down to 31.4 from 57 point something, and…”
David Sinclair Jan 2, 2019 ▶ 16:38 a16z Podcast | How to Live Longer and Better

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