Cardiovascular Disease
topic on 7 shows · 9 statements across 7 episodes
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the a16z Podcast
9 statements about Cardiovascular Disease, every show
Hodak: Cardiovascular disease and non-brain cancer are attackable via organ replacement
“The two leading causes of death though, are cardiovascular disease and cancer is not metastasized to the brain. And I think both of those are going to be really attackable through this type of work.”
Carnell: Novo Nordisk data shows GLP-1s cut cardiovascular risk over 20%
“We've got compelling data right now, ah, out of Novo Nordisk over the last year that basically shows that by taking GLP-I medicines, there is a, you know, north of 20% reduction in our risk of having a heart attack or a stroke. And what I thought was pretty pr…”
Alex Carnell: Genetic PCSK9 deficiency reduces cardiovascular disease risk by 88%
“With longitudinal studies over 15 years, the fact that they were genetically deficient in the production of the PCSK-IX protein led to them having an 88% reduction in the risk of ever developing cardiovascular disease.”
Carnell: PCSK9 Inhibitors Have More Favorable Risk-Reward Than Statins
“If you start taking a PCSK nine inhibitor earlier in your life, Which, by the way, I think the risk reward is actually even more favorable than statins in terms of human health, but we know that you won't progress to cardiovascular disease.”
Lyon: Alzheimer's, Heart Disease, and Diabetes Are Symptoms of Unhealthy Muscle
“Alzheimer's, cardiovascular disease, Diabetes, obesity, that these are all symptoms of unhealthy skeletal muscle”
Topol: Lifestyle changes can prevent up to 90% of cardiovascular disease
“They, ah, are preventable variably, so cardiovascular, 80 and 90% from lifestyle and related factors, modifiable factors, like your LDL cholesterol, that kind of thing.”
Heart disease kills 40% more people than all cancers combined
“Heart attacks are the number one cause of death. They're the number one cause of death in men and women. Cardiovascular disease deaths are the number one cause of death and total 40% more deaths than all cancers combined.”
Hillenmeyer: Hexagon Bio discovered fungal compounds targeting cardiovascular pathways
“So we've seen we rediscovered the statins themselves, as I mentioned, we've seen other drugs evolving in that same kind of cholesterol pathway. And we also see other totally unrelated chemicals in unrelated pathways that could also have an effect on cardiovasc…”