AI
also referred to as: ais · artificial intelligence
107 statements across 49 episodes · 63 bullish · 25 bearish · 47 people on the record · first statement Jun 29, 2021 by Dr. Rick Klausner · across every show →
Everything said about AI, oldest first
Jun 29, 2021 positive
Klausner: DNA manipulation and AI convergence are biology's key breakthroughs
“I think the most important breakthroughs has been the ability to read and write DNA. The new ability to actually manipulate and edit DNA. And then I think the convergence of tech and computational sciences and artificial intelligence, machine learning with bio…”
Feb 16, 2022 positive
Apr 19, 2023 neutral
Apr 19, 2023 negative
Apr 19, 2023 positive
Jun 15, 2023 positive
AI will diagnose employee performance, but human leaders must provide motivation
“I don't think AI is going to be able to motivate you. I think there's going to be great leaders that are going to, well, maybe it will be able to motivate you, but I think AI will be great at diagnosing where you need to improve. So I think that combination of…”
Jul 14, 2023 negative
Jul 14, 2023 bullish
Karp: Palantir AI identifies adversary positions across large land masses
“The most powerful use of our product currently, and again, of one of our products is Being able to identify an adversary over a large lying mass using AI, and that obviously it's been reported has led to a different level of ability to acquire the adversary's …”
Jul 18, 2023 positive
Andreessen: AI should liberate humans to focus on uniquely human fulfillment
“Increased technology and a particular AI should basically actually make it possible to be more human. You should be able to spend more of your life doing things that are human in, in their nature and human in the sense of fulfillment, as opposed to doing the t…”
Jul 18, 2023 negative
Andreessen: AI will revive far-left dreams of central economic planning
“AI is like gonna create a whole new set of dreams of state power, and like I said, the Chinese have one version of that, but, you know, on the far left even in the US, you have this idea the, there's a book called Fully Automated Luxury Communism which is this…”
Jul 18, 2023 bearish
Andreessen: AIs will not get certified as doctors or lawyers anytime soon
“And my, the point in that essay is what Joe just said, which is like, it will be illegal to do that. Like, it's not going to happen because it's going to be illegal. Like AIs are not going to get certified as doctors and lawyers anytime soon. Like that, that I…”
Jul 18, 2023 positive
Jul 18, 2023 negative
Jul 18, 2023 positive
Andreessen: AI will favor defense over offense and reduce violence
“Arguably this swings AI swings very much the advantage of the defender over the attacker, and I think maybe we're already seeing that play out in Ukraine... My guess is this tilts in the direction of defense and therefore in the direction of probably actually …”
Aug 18, 2023 neutral
Aug 18, 2023 positive
Aug 18, 2023 neutral
McGrew: AI scaling will ultimately be constrained by power and chips
“You know, the interesting thing about AI is, in the end, it's going to be limited by things like power. You know, if you're, and, you know, chips, and if you're trying to build these really massive clusters in 10 years or whatever.”
Aug 18, 2023 neutral
Oct 25, 2023 bullish
Oct 25, 2023 bullish
Gerstner: AI will be bigger and more important than internet, mobile, and cloud
“I think AI, or I like to talk about augmented intelligence, will be more important to humanity. Then the first three super cycles I've lived through, which are internet, mobile, and cloud. I think it'll be bigger, and so I don't buy that thesis.”
Oct 25, 2023 bullish
Oct 25, 2023 bullish
Jan 31, 2024 negative
Verdon: Multi-year regulatory cycles are too slow for AI progress
“AI is moving on a timescale of month to month, week to week, and, you know, regulations are on a few-year timescale at best put together, and that's just too slow of a feedback loop, and it's too heavy-handed, and it's probably not the way forward.”
Jan 31, 2024 positive
Verdon: Market incentives and liability will ensure AI alignment
“People wouldn't pay for an AI that's unaligned, doesn't do what you say, and is nefarious, right? They would pay for an AI that does, you know, is a good worker, let's say is aligned and is reliable, right? And if the, you know, the person or the company that …”
Feb 14, 2024 bullish
Emil Michael: US will innovate on AI faster than anywhere else
“The next wave of AI, which is going to produce mass efficiency, mass knowledge dissemination nowhere but here. You know, we're going to have the first of everything in this new platform that's building. If you thought about the last platform as the iPhone and …”
Feb 29, 2024 negative
Lomborg: Effective Altruism prioritizes existential risks over immediate global health
“Effective altruism is obviously a great idea. And they're very, very much in the same wavelength as what we are. But my senses are we often disagree because see, they have sort of gone off on this more interesting rich world trend of saying, oh, but the big th…”
Mar 21, 2024 neutral
Apr 11, 2024 bullish
New service firms will emerge exclusively to deploy enterprise AI.
“There's going to be probably even companies that are built just like new services companies that all they do is deploy AI in the enterprise. Then I think we have a role over there as well as the solution they would use to accelerate those deployments.”
Nov 2, 2024 bullish
Gil: The ultimate end product of AI is rentable units of cognition
“I think what people are really misunderstanding is what is going to be the end product. And I think the end product is units of cognition. Right. You're going to be effectively paying for or renting something that's going to think or do things on your behalf.”
Nov 2, 2024 bullish
Lonsdale: AI can already double productivity across $2.1T in US services
“I think in the 2.1 trillion that we think could be addressed right now, stuff like healthcare billing, logistics billing, auditing, whatever, legal, some legal stuff, we think already you can at least double the productivity, which would be kind of a trillion …”
Nov 2, 2024 bullish
Gil: Machine intelligence will eventually dominate total brain equivalents
“There'd be like three eras of mankind in terms of, or three eras of intelligence, right? And the first era is basically people. And the second era is some hybrid era where it's a you know, if you look at the number of intelligence units or whatever you want to…”
Nov 2, 2024 bullish
Dec 6, 2024 negative
Dec 6, 2024 positive
Sirota: AI up-levels junior engineers while seniors shift to architecture
“The junior mid-level engineers are able to be a lot more efficient, feel like they're able to actually learn by having the AI suggest code. So I'm seeing it a little bit more of the opposite that it's actually Up-leveling a lot of the mid-level engineers, the …”
Dec 13, 2024
Dec 13, 2024 bullish
McCord: Prime Intellect's Decentralized Training Run Challenges Centralization Assumptions
“There's a huge decentralized training run that I think prime intellect did recently that, you know, shows that the assumptions everyone has about how AI is just going to be a centralized thing could be wrong.”
Dec 13, 2024 negative
Dec 13, 2024 negative
McCord: Human biological passivity makes AI cognitive offloading uniquely dangerous
“Human brain works on glucose. There's only so much glucose to go around. We're biologically wired to be passive. So AI presents this very interesting, sinister. It's very good in the sense that it can offload plausibly everything, but it's bad in the sense tha…”
Dec 13, 2024 negative
Lonsdale restricts children's screen time, calling current AI design a drug
“We don't actually use screens very much, because I'm a little bit afraid of the interactions with them, and like what, you know, I see a lot of this AI design as it is right now, as like, it's a form of drug in some sense, right? Because basically it's trying …”
Dec 13, 2024 negative
Jan 23, 2025 positive
Feb 14, 2025 negative
Urban: AI-enabled bioweapons pose a severe risk in the near future
“I think that in the near future, of course, you're going to have a higher risk of
Bad guys with using AI, you know, to do things like manufacturing scary bioweapons things like that, that you really, you know, things that could really kill a billion people.”
Feb 14, 2025
Feb 14, 2025 bearish
Feb 14, 2025 bullish
Mar 14, 2025 bullish
Israetel: AI will reach superintelligence by 2026 and vastly surpass humans by 2029
“Once AI becomes super intelligent, which should occur in like 20, 26 or something like that. If it hasn't already, I'm not kidding. I'm not saying this very soon. Once it's super intelligent and then by 20, 29, it's going to be like orders of magnitude smarter…”
Mar 14, 2025 positive
Israetel: The early 2030s will bring a massive aesthetic and longevity revolution
“As everyone gets wealthier, and the problems of the world are beginning to be more tractable. AI is helping a lot there. I think there's going to be a turn inwards to where people want to look better, feel better, live longer, be healthier, and also work on th…”
Mar 14, 2025 bullish
Apr 17, 2025 positive
May 17, 2025 bearish
Lessin: AI is not disruptive and incumbents should broadly win
“You know, I'd actually argue that AI is kind of like mobile. It's not disruptive. It's great tech to be clear. It's important, but just as the internet, I would say that just as like mobile was just More internet and pervasive internet. AI is just like more te…”
Jun 12, 2025 positive
Scott Wu: AI balances more technical because hard problem-solving yields obvious businesses
“I think that the balance in AI does just inherently swing a lot more technical. You know, it's, there are a lot of pure technical problems that if you can just solve these really, really hard problems, it is incredibly clear, you know, what happens and how you…”
Jul 3, 2025 bullish
Lonsdale: AI could cut healthcare costs by up to two-thirds
“It's very obvious that AI can make these things a half, a third the cost for better outcomes, and yet every one of our states in this country Has very powerful provider and payer lobbies and has very powerful cartels that block competition.”
Jul 16, 2025
Sofman: Autonomous driving AI must optimize for worst case, not average case
“This is one of those where oftentimes you think of like AI or products where it's like, yeah, get it out there and iterate. This is one of those where you're optimizing for the worst case, not the average case. This isn't search where you give some bogus resul…”
Jul 28, 2025 bullish
Jul 28, 2025 bullish
Aug 29, 2025 neutral
Aug 29, 2025 positive
Sep 15, 2025 bullish
Meyer: AI Slop Will Drive Industry Professionals Toward Human-Curated Journalism
“We think that as that approaches sort of unsustainable levels for people that are looking to do good work, for people that work in industry especially, that they're going to look for curated sources of information and for high quality work that humans are doin…”
Sep 25, 2025 bullish
Lonsdale Argues Construction Automation Is Currently Creating More Net Jobs
“Is one, right now there's several million unfilled vocational jobs, and every time, for example, a new technology comes out that automates something for construction, it also creates massive more demand for construction. So right now, so far, the AI is actuall…”
Sep 25, 2025 bearish
Sep 25, 2025 bearish
Levi Predicts AI and Robotics Will Soon Perform Every Human Job
“So, very, very, very, very, very soon, we are going to find ourselves in a reality where AI, coupled with robotics, can essentially do every job.
Not just the jobs we don't want to do.
It can do any job and every job, even the jobs that we really like to do.”
Oct 9, 2025 bearish
Carvalho: 40,000-student campuses and 300-person lecture halls are obsolete due to AI
“Because of AI, because of the technology that we have in front of us right now, the idea of a 40,000 student campus to me is completely broken. Why would you sit in a class with 300 people? Where, you know, you can engage with a bot and teach you probably bett…”
Oct 17, 2025 negative
Nov 21, 2025 negative
Lonsdale: Advanced AI will evolve its own incomprehensible language
“A few of my friends are worried about the AI learning their own language that we can't understand, because there's probably a natural way for them to communicate that's better than our language, and it looks like it might already starting to be trying to learn…”
Nov 21, 2025 positive
Lonsdale: Self-taught chess AI organically reinvents historical human openings
“When we taught AI to play chess, the way it learns, if you start it from just knowing nothing, and it plays against itself billions of times throughout a day, it actually goes through some of the more popular historical openings that people were liked too, and…”
Dec 11, 2025 positive
Lonsdale: An Arab country deployed AI to cut permitting time to 120 minutes
“Some of actually the Israelis who work with him and some of my friends had built him technology for a whole country that, that would make permitting only take a 120 minutes. And so they're actually making the rule where when you try to get a permit in this cou…”
Dec 30, 2025 positive
Sununu: AI will extend human lifespans to 100-105 and cure cancer
“I do believe all this amazing AI technology is people, I think people's lifespans are going to increase exponentially. Not until like 200 years, but we're not going to be living to 75, but we're going to be more commonly living to a hundred or a 105. There'll …”
Dec 30, 2025 bullish
Feb 17, 2026 bullish
Feb 17, 2026 positive
Kolicich: AI excels at workflows reducible to five core cognitive skills
“There's five key things that AI is good at. Like, these are the tasks. You can add one more now, computer use, but you think AI is good at multi-turn conversations, document understanding, structured output, Search and reasoning. If you can break a workflow do…”
Feb 17, 2026 bullish
Kolicich: AI will create massive wealth and could be massively deflationary
“I think it's going to be incredibly disruptive, but positive, create incredible amounts of wealth. You know, a lot of Sectors are going to get much more efficient. There's like very bold cases where it's massively deflationary.”
Feb 27, 2026 bullish
Ross: AI puts new career entrants on equal footing with industry veterans
“And this is the second time in my career where everyone's sort of kind of getting back to equal footing, and so young people who are just getting into their careers just starting are on equal ground with people like me, people like you who have spent 10, 2030 …”
Feb 27, 2026 neutral
Mar 19, 2026 neutral
Mar 19, 2026 bearish
Wu: AI will delete jobs at 100x the Industrial Revolution's speed
“I think a lot of jobs will be deleted. And I think it'll be on entrepreneurs and founders and investors to create new opportunities for people. So I think we're entering a very interesting time where there, it is industrial revolution times the hundred speed, …”
Mar 27, 2026 positive
Wu: Cognition lets engineering candidates use unlimited AI during interviews
“For us, and this has always been the case for us, you know, our interview process has always been, you can use as much AI as you want to use. You know, it's just like, we're going to give you a few hours, just build, build your whole own product surface, right…”
Mar 27, 2026 bullish
Mar 27, 2026 bullish
Wu: Technical execution matters more in AI than in past tech waves
“I think in AI, what you see is that really excelling on the technical aspect just matters much more, I think, in AI than some of these other fields, and I think there's been lots and lots of businesses in the past that have been very, I'll say, like very inten…”
Mar 27, 2026 negative
Apr 3, 2026 neutral
Apr 3, 2026 positive
Apr 9, 2026 positive
Fry: SMBs Should Use AI for Revenue Growth, Not Cost Cutting
“A lot of people think of AI and they think of cost cutting and they're like, oh, we can really optimize our P and L. We can use AI, automate all these jobs, cut costs. That's not the right lens to look at small businesses. And it's not right for really one rea…”
Apr 17, 2026 bullish
Apr 17, 2026 positive
Lonsdale: Prompting AI to Explain Academic Papers Enables Fast Learning
“I actually, one of the hacks That I really enjoy when I have free time is to ask the AI, like, what are the most interesting and important or cited papers or new papers or controversial papers in a field? And then explain these to me as if I only have an under…”
Apr 17, 2026 bullish
Melas-Kyriazi: AI Data Extraction From Unknown Documents Requires Human QA
“What's tougher is feeding in a completely unknown document and having AI extracted well out of the unknown documents. We do that currently, but we use humans in the loop to make sure that we QA. It is not a fully solved problem yet. We think it will be in the …”
Apr 17, 2026 positive
Melas-Kyriazi: AI Enables Investors to Conduct Technical Diligence Within Hours
“I think like AI as a technical co-pilot for diligence is actually one of the most interesting use cases for AI. As an investor right now. I don't think it's a replacement for human experts necessarily, but it certainly is a huge help. If you're, if you come ac…”
Apr 17, 2026 bearish
Melas-Kyriazi: AI Has Eradicated Traditional SaaS Switching Cost Moats
“Because of AI, that's changing. It's cheaper for competitors to build software. It's cheaper for people to vibe code their own software. And it's also easier to migrate data because of AI agents. So I think switching costs have gone down. And so I think it's r…”
May 19, 2026 negative
May 19, 2026 bullish
May 22, 2026 positive
Scott: AI Amplifies Core Product Management Skills and Prototyping
“I think it bifurcates the skills a little bit. So the things that made a really good product manager, a good product manager then are only amplified. So deep understanding of the customer, ability to articulate your ideas to a team with varied skills. AI only …”
May 22, 2026 bullish
Scott: The narrative that only AI, defense, and energy matter is untrue
“What you're seeing in the headlines today is basically, Hey, AI is all that matters.
Maybe defense matters because the world is becoming a slightly more volatile place, and energy matters as a derivative of AI.
So if you're not already super exposed to those i…”
May 22, 2026 positive
Scott: AI will slash enterprise operating costs without destroying structural moats
“We don't want to see AI impacting their moat. So if they have a network effect, a cost of capital advantage, a regulatory moat, Those things are not going to go away with AI. However, their operating costs should be falling off a cliff.”
May 29, 2026 positive
Jun 18, 2026 bullish
Ghamsari: The 2030s will be the greatest economic boom in a century
“I think that the economy in the, I think the 20 thirties are going to be the most, it's going to be the most booming decade in a hundred years. It's going to be one of those decades where there's so much opportunity created by all the new things that we can't …”
Jul 2, 2026
Jul 9, 2026
Jul 9, 2026 negative
Jul 9, 2026 bullish
Jul 9, 2026 bullish
Kolicich: AI investment at 4% of GDP lags historical industrial revolutions
“If you look at the Industrial Revolution in Russia in the early 20th century, I think investment as a percentage of GDP got up to 20 or 25%, and then China was investing 40 or 50% in their industrial revolution of GDP, and now in AI we're investing, like, thre…”
Jul 9, 2026 bullish
Jul 24, 2026
AI attack agents will operate 1,000 times faster than humans
“The day where a human would break in, and if you were 10 minutes behind the human on defense, you could stop the impact of a breach, is going to end. There's going to be an agent that breaks in, then another agent uploaded because it had remote code access, Re…”
Jul 24, 2026 neutral
Jul 24, 2026 bullish
Jul 30, 2026 neutral
Jul 30, 2026 neutral
Jul 30, 2026 neutral
Levie: Real-World Diffusion, Not Intelligence, Is AI's Ultimate Rate Limiter
“Diffusion actually is, like, your biggest rate limiter, and diffusion is, like, a human, Has to get the intelligence from the model plus probably their data, and then they have to go interact with the real world and do something in the real world, and then bri…”