The Ledger, every show

“Unless you ask those three questions of what must be true, what must remain true, and what would change to make that entirely untrue, you don't pressure test the ideas well enough and you're stuck in this very narrow band of thought.”

“We can probably know immediate things with high certainty, and we can probably know long-term things with reasonable certainty, but in the middle, we just have fog and everyone plays in the middle of fog.”

“So that, that is an idea that is introduced to me of you are hungry and you should eat. And so I, the same with a new idea, I watched the idea land. I watch who responds and I just witness and observe the whole thing.”

“I've been very clear with them that I will teach through example. I'll offer my perspective, but it is their choice on what they do, you know, on a moment to moment basis.”

“I've, no, I don't. I've recreated my social life, my community. I've gotten, it was growing up in a religion community is solved for you. Everyone is there for you. They're all similar. You all have the same beliefs. It's easy to have friends. It's easy to get…”

“After doing this for years, when you sleep poorly, you do normalize to it, but you're normalized to a blurred state of reality. You don't remember what the clarity of good sleep feels like.”

“You can't be getting four hours of sleep a night and having a poor diet and exercise. You, you're going to render yourself. You can't Overcome that level of intoxication. You're legitimately intoxicated by mind, and you're just impaired.”

“My dad is 71. His life expectancy based upon how he's lived his life is 68. He's been obese, and he's done hard hard drugs, and so I've been working with him on Project Keep Dad Alive. And he's been doing all the advanced therapies I have. He's on blueprint.”

“No. It makes me endlessly happy.”

“Reframe your identity, that you are a professional sleeper. So in the same way that each one of us every day shows up to our meetings on time, if we're two minutes late, we apologize. So set your bedtime and show up on time. And if you're two minutes late, apo…”

“I would make sleep your number one life priority. Like the most important thing you do in any given day is high quality sleep. And I would build your life around it because when you have good sleep, So many of the things in life are much better, and then if yo…”

“My cardiovascular capacity Is in the top 1.5% of 18 year olds. My bone mineral density is the top .2% of 30 year olds, which is age minute for that test.”

“If I eat at five PM or six PM, then my resting heart rate is going to be 56. And when I do that, I'm going to knock off about 50% of my REM and 50% of my deep, and I'll increase my wake time by about 35 minutes.”

“The more important number is what is the biological age of my heart and of my lungs and of my liver. And that's really the more powerful predictor than a chronological number.”

“I break myself out into different persons, and I decide which versions of me have authorization and when. Because, you know, like who, who's in charge 10 PM you who sets the alarm for six AM or six AM you who wants a few more minutes with the snooze button. An…”

“One is I would suggest you not change anything in your life for six to 12 months. Keep on with your same habits and have the money so you can distinguish between your preferred lifestyle and what money would otherwise alter Your perception of what you want”

“I maintain good posture because I discovered I've got genetically narrow internal jugular veins, these two pipes on the side of the neck. And so I've have restricted blood flow out of my brain when I have bad posture. So it kinks my veins.”

“If you're male and you're not getting enough sleep, your nighttime erections are eliminated. And nighttime erections are an important biomarker for sexual health, psychological health and cardiovascular health.”

“There's a cloning therapies that are being developed So if you had a few follicles, you can clone it and then do basically like implantation. So I think it's a possibility that in like five years time that you would be able to restore hair yourself.”

“Biologically, I'm a few hundred different ages. And so you, for example, if you're looking at the age of your heart, you can characterize The age of the heart through a few dozen markers. You can do the same thing with other parts of the body. So you're actual…”

“PayPal had Growing up during the internet, but they had stopped really innovating for a couple of years. And so developers didn't have the tools they liked.”

“I was not willing to trade my time for money. You know, if someone was going to say, I'll pay you 15 dollars an hour to do blank. I didn't want to make that exchange. I wanted to say, I am willing to take zero for an indefinite period of time. In exchange, the…”

“I hit three hundred million.”

“Cash is king. Like don't put your money in anything that's going to be illiquid. So there's been times in the past couple of years where I desperately needed cash and it was not, I didn't have liquid levels that I wanted it. And so liquidity for entrepreneurs …”

“Most people think that their self-awareness Is basically the sensor system that captures their brain. Like because I'm conscious and because I can feel when I have a headache, it basically is a robust enough sensor system to do it. And that's not correct. So m…”

“I eat 1977 calories per day. That's it. Not anymore. And that is my absolute budget and I cannot go over it.”

“People ask me like, do you have cheat days? And like, no, like I, a cheat day sounds awful to me. It sounds like the worst feeling in the world to be full and to be regretful.”

“It's very hard to get someone's real opinion of you because it's difficult for someone to be honest, but what we all know when we go home from work and we're talking to our significant others, like that's the truth serum in action, you know, like where we real…”

“So if you look at the pyramid of measurement, Wearables are like part of the first category. And then you get to biofluids, like blood draws and, you know, urine and whatever else. Imaging is an entirely different quality class. And so if you want to get reall…”

“I spent, during that time, a lot of, spent a lot of time reading science and technology and trying to figure out where the human race was going, and I came to, like, was one realization that changed my outlook and my understanding forever, my relationship with…”

“So at this point in my life, I've decided to use to pursue capitalistic models where I can invest in something, it can make money, and then it can also return a greater sum to me.”

“I love it. It's a fantastic technology. It's that, I mean, I guess I kind of think of it like, I mean, the blockchain technology, I kind of think of it like the printing press, where when we figured out how we could, someone could write words, and it could be …”

“We want to test 20% of the foods that make up 80% of the US diet, so then we can say, on average, the average American consumes blank, you know, mercury per day, or cadmium, or whatever.”

“These contaminants wreak havoc on the body. It can create neurological dysfunction. It can cause asthma. It can cause lung irritation. It just like its whole body damage. It gets into tissues. It lodges in. It's very hard to remove it. So it's not like somethi…”

“I mean, so when I was 34, so I, yeah, in one year's time, I sold my company. I got a divorce. I left my religion and I came out of depression. So all in one year's time.”

“For breakfast, I have broccoli, cauliflower, black lentils, garlic, ginger. For my next meal, I have macadamia nuts, walnuts, flaxseed, pomegranate juice, Berries, pea protein, and hemp protein. My final meal of the day is some kind of combination of berries, …”

“I, I'm so fluent in biographies. I can at will have a dialogue with them in my mind.”

“We helped Uber do their no the payment experience where you get in the car, you arrive at your destination, you leave the car, no exchange of payment information, no signing of receipts, no printing out receipts.”

“The first product was for OpenTable. It was just allowing someone to make a reservation, put in their credit card number and have it stored. So to the user, it appeared as if I was entering my credit card information in the OpenTable system, when in fact they'…”

“At the 11 month mark, my portfolio of customers were generating, I think it was like 59,000 a month of revenue.”

“Ginkgo Bioworks, one of my first investments, I ended up working on the mRNA vaccine.”

“Accumulation of money was not my objective. And I could have stuck with the company and we could have made more, you know, been more valuable, but it was like, okay, so if I do this, it's three hundred million. That's a good enough starting base to go off into…”

“What we, at Kernel what we've done is we've built a neuroimaging helmet. Like you said, Sam, you just put it on your head. It takes one minute to set up. It uses light to measure the brain activity.”

“I'm vegan for ethical and moral reasons, but I'm not vegan because I think it's you know, I didn't, at the, at labor abstraction, we just put the data. We're agnostic to these inputs.”

“So just like we have five sonographers to run the ultrasound machine, we have specialists in lung, specialists in the heart, specialists in other areas. So the team is like 25 or so maybe now all together that have different specialties.”

“So we used we went out and analyzed a number of different decision-making processes for Big Pharma and Big Oil, how they actually gather data, process data, and make decisions. So we used decision analysis and created a model that helped guide us through what …”

“We've been mostly in synthetic biology and genomics, done some space and AI. But material science is an area that's very interesting to us.”

“Yeah, we, so quite a few. Like we like DC, VC, Founders Fund, Lux Capital. There's like, there's probably like a dozen or so we love that we love working with. They again are just Great people, good processes, smart minds, and very collaborative.”