Rare Diseases

topic on 4 shows · 5 statements across 5 episodes

We Live to Build American Optimist No Priors the a16z Podcast

5 statements about Rare Diseases, every show

NO PRIORS Insight
Zuckerberg: Studying rare edge cases yields more insights than common diseases
“I think one of the interesting things from, you know, science and engineering is that often, you know, you can hit your head against the wall on the common problems, and in this case, diseases, but a lot of times you, like, learn a lot more about a system from…”
Mark Zuckerberg Jun 10, 2026 ▶ 37:00 “Curing All Disease by next century is too conservative" - Mark Zuckerberg
a16z Opinion
Chan: Most medical conditions should be treated as rare diseases
“And so those are rare, like, and, but I really think most diseases should be thought of as rare diseases. Because each one of our biology is different.”
Priscilla Chan Nov 6, 2025 ▶ 13:31 Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
a16z Insight
Horowitz: Venture capital cannot fund rare disease cures due to $1B costs
“One of the things that's almost impossible to do from a venture capital standpoint is cure rare disease, because it costs a billion dollars to bring a drug to market, and then they don't all work, so, you know, multiply that. And there just aren't that many, i…”
Ben Horowitz Jul 16, 2024 ▶ 59:11 Trump Vs. Biden: Tech Policy
WE LIVE TO BUILD Assertion Supported
Spohr: Rare diseases affect as many Americans as cardiac disease
“There are as many people in America, excuse me, suffering from a rare disease as there are people suffering from cardiac disease.”
Matthew Spohr Dec 13, 2022 ▶ 33:45 He Closed the Paper the Same Month He Buried His Wife
Gimenez: Decentralized biotech enables curing long-tail rare diseases centralized systems ignore
“If you think about that same model of like this long tail, it can be profitable if you think at a global scale, and we actually reduce the cost to actually start these kinds of innovations and distribute them to people. And think about that in the context of d…”
Dr. Francisco Gimenez Apr 18, 2022 ▶ 39:26 The Year That Changed Medicine Forever | Francisco Gimenez Explains the Biotech Revolution. · Joe Lonsdale

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