Heart Disease

topic on 7 shows · 15 statements across 12 episodes

the Knowledge Project My First Million No Priors A Product Market Fit Show the a16z Podcast All-In 20VC

15 statements about Heart Disease, every show

a16z Assertion Contradicted
Mares: US healthcare outcomes are worsening with chronic disease at record levels
“If you look at any data in the US healthcare outcomes are horrible. Like, they're bad, they're getting worse, like obesity, you know, heart disease, all of these conditions are basically at record levels and continue to go up.”
Justin Mares Feb 4, 2026 ▶ 1:12 How Truemed Is Incentivizing Americans to Invest in Prevention
a16z Assertion Partly supported
Mares: US childhood obesity and heart disease escalated in the 1970s
“Things started to get much worse in the 19 seventies. You know, basically I think my view is that that is around the time when you started to see childhood obesity tick up. You started to see obesity, heart disease, things like this kind of start to move.”
Justin Mares Feb 4, 2026 ▶ 4:19 How Truemed Is Incentivizing Americans to Invest in Prevention
NO PRIORS Assertion Contradicted
Nadler: Medical error is the third leading cause of US deaths
“It's well known, and it's been often repeated, that medical error is a third leading cause of death in the United States after heart disease and cancer.”
Daniel Nadler Sep 5, 2025 ▶ 4:43 No Priors Ep. 130 | With OpenEvidence Founder Daniel Nadler
a16z Assertion Partly supported
Topol: Major age-related diseases incubate for 20 years before symptoms
“It takes 20 years to get these diseases, with rare exception. You know, heart disease, almost all cancers, and neurodegenerative, they are incubating for a very long time.”
Dr. Eric Topol May 27, 2025 ▶ 3:42 7 More Healthy Years: What We Can Learn from Super Agers
PRODUCT MARKET FIT Assertion Supported
The first symptom of heart disease is often a catastrophic event
“The most common presentation for having heart disease like that is not presenting with chest pain or shortness of breath, but it's simply having a catastrophic event, dying of a heart attack or suffering a heart attack at home with no antecedent warning.”
Dr. Jim Apr 14, 2025 ▶ 3:40 He raised $300M to prevent heart attacks. Here's how he got his health tech startup off the groun... · PMF Show
Arterial plaque buildup integrates a lifetime of heart disease risk factors
“When something has too many factors that are contributing to the disease, I think that the best way to do it is to find a single metric that integrates the lifetime exposure of That, to that, of that individual, to all of those known and unknown risk factors, …”
Dr. Jim Apr 14, 2025 ▶ 6:09 He raised $300M to prevent heart attacks. Here's how he got his health tech startup off the groun... · PMF Show
PRODUCT MARKET FIT Assertion Supported
Dr. Jim Min: 15–20M Americans present yearly with heart disease symptoms
“It's about somewhere between 15 and twenty million people in the US every year who present like that.”
Dr. Jim Apr 14, 2025 ▶ 29:35 He raised $300M to prevent heart attacks. Here's how he got his health tech startup off the groun... · PMF Show
MY FIRST MILLION Assertion Not checkable as stated
Means: Nine of the top ten US killers are diet-driven
“Nine out of 10 killers of Americans are foodborne illnesses. I mean, we can dance around it. It's just that simple. Like, you would wipe out heart disease, diabetes, kidney disease, respiratory illness, COVID deaths even, if you got our country metabolically m…”
Calley Means Jun 26, 2024 ▶ 48:22 The Dark Story Behind Ozempic’s $500B Business Empire
MY FIRST MILLION Assertion Partly supported
Nagpal: North American Indians face 4x higher risk of heart disease
“Like an Indian person living in North America, right? So we have the same exact like upbringing, whatever, is anywhere between four to six times more likely to have heart disease, diabetes, like it's just, it's real bad.”
Ankur Nagpal Jan 17, 2024 ▶ 49:39 $250M Founder Reveals How The Rich Avoid Taxes (Legally) | ft. Ankur Nagpal
a16z Assertion Supported
Robbins: 4,000 people die daily from heart disease and cancer
“4000 people die every day of heart disease and cancer, and no one says a word.”
Tony Robbins Dec 20, 2023 ▶ 40:24 Tony Robbins on the Future of Health & Longevity
ALL-IN Assertion Supported
Chamath Palihapitiya links GDP growth in emerging economies to spikes in diabetes and heart disease
“You look at these emerging economies, and as GDP cranks, the first thing that happens is heart disease cranks up, and diabetes cranks up”
Chamath Palihapitiya Dec 1, 2023 ▶ 36:13 Tucker Carlson: State of America, leaving Fox News, Media Control, Politics, and more
Sinclair: Reversing Biological Age Will Eliminate Alzheimer's and Cancer
“Truly reset the age of the body and diseases of aging, like Alzheimer's and heart disease, even cancer will go away if we become young again.”
Dr. David Sinclair May 3, 2022 ▶ 1:11:27 David Sinclair: Reversing the Aging Process
Barrett: Depression, anxiety, and heart disease stem from body budget deficits
“It translates into depression, anxiety, heart disease, diabetes. They're all metabolic illnesses that come from a debt, running a deficit in your body budget.”
Lisa Feldman Barrett Sep 15, 2020 ▶ 32:07 #92 Lisa Feldman Barrett: Balancing the Brain Budget
a16z Assertion Supported
Age is the primary underlying risk factor for heart disease and cancer
“Now, these are fundamentally very different diseases, different symptoms, different progressions, but they share the same underlying driving risk factor, which is how old you are.”
Kristen Fortney Dec 23, 2018 ▶ 0:18 Extending Human Lifespan
20VC Disclosure
Deming: All Longevity Fund portfolio companies target multi-disease pathways
“All the companies that we invest in have drugs that have worked not just in kind of mouse models of Alzheimer's typically, but also diabetes and heart disease, and kind of typically the pathways that we invest in have been tested in and work in almost every Ag…”
Laura Deming Nov 26, 2018 ▶ 13:16 20VC: Why Raising A First Time Fund Is Like Raising A Seed Round, Why We Need New and Different Fund Models & Why Longevity Is The Most Rewarding Place To Invest with Laura Deming, Founding Partner @ The Longevity Fund

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