Default Mode Network

topic on 5 shows · 6 statements across 6 episodes

the Y Combinator Startup Podcast We Live to Build the Knowledge Project BigDeal All-In

6 statements about Default Mode Network, every show

ALL-IN Assertion Not checkable as stated
Bryan Johnson: 5-MeO-DMT annihilates the default mode network compared to psilocybin
“Five MEO DMT compared to psilocybin, like just absolutely like blasted clean. My default mode network. It felt like psilocybin dampens it, like it softens it, but this thing just annihilated my default mode network.”
Bryan Johnson Mar 26, 2026 ▶ 10:07 Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
BIGDEAL Insight
Sanchez: Asking questions immediately halts the listener's default mode network
“And questions shut that down instantly. It like immediately forces the brain to come into the present moment, whether it wants to or not. And this is how you pull anyone back into the conversation, even if they were drifting.”
Codie Sanchez Dec 22, 2025 ▶ 11:27 Stop Rambling: The 3-2-1 Speaking Trick That Makes You Sound Like A CEO
WE LIVE TO BUILD Assertion Supported
Strauss: Classical psychedelics downregulate default mode network and enable cross-brain communication
“Classical psychedelics seem to do a few things. The first thing they do is they seem to Downregulate the default mode network. And so the default mode network, which is responsible for sort of inhibiting connections between parts of the brain that don't normal…”
Tyler Strauss Mar 8, 2022 ▶ 29:57 Your Brain Has Only 3% of Its Vision in Focus Right Now
KNOWLEDGE PROJECT Assertion Partly supported
Kelly: Glimpsing balances default mode network and triggers synchronized gamma brainwaves
“And it actually, when you're in an fMRI, which I've been, it balances, if you keep going, it'll balance your default mode network and your task mode network. It will open your parietal lobe. It'll not only calm you, moving you from beta to alpha, but it'll act…”
Loch Kelly Feb 9, 2021 ▶ 44:17 #103 Loch Kelly: Effortless Mindfulness
Oakley: Learning requires alternating between focused and diffuse modes of thinking
“And that learning involves going back and forth between these two different modes. And if you don't get something the first time, guess what? That's okay. If you don't get it when you're sitting there focusing the first time, Back off, you know, after you focu…”
Barbara Oakley Apr 10, 2018 ▶ 13:47 #31 Barbara Oakley: Learning How to Learn
Y COMBINATOR Assertion Supported
Watts: Meditation and psychedelics similarly deactivate default mode network
“Meditation does that too. It quietens down that mental control. The monkey mind. It's quieting the monkey mind. That's all I would say really we're doing with psychedelics and with meditation.”
Dr. Rosalind Watts Mar 15, 2018 ▶ 48:49 Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts · Y Combinator

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