Epigenome
topic on 2 shows · 3 statements across 3 episodes
3 statements about Epigenome, every show
Friedberg: Study shows fat cells retain epigenetic memory after weight loss
“In humans, they basically took five individuals that were obese and lost more than 25% BMI. And they looked at the epigenome, they looked at the markers of what genes are upregulated and downregulated before and after they lost the weight. After they lost the …”
Belmonte: Closed chromatin maintains cell youth while open chromatin causes aging
“When the epigenome, when the chromatin is closed, we call this heterochromatin, the cell is young, is healthy. When the chromatin is open, it leads to the increase, the loss of buffer capacity, and therefore, disease and aging.”
Sinclair: Epigenetic information loss is the primary driver of aging and disease
“Eventually born, and this epigenomic information that tells cells how to behave, we think breaks down over time, and that results in diseases, tissue dysfunction, so, you know, you start to look older, you can't clear toxins, you can't think well, your nerve c…”