Sinclair: Epigenetic information loss is the primary driver of aging and disease
Dr. David Sinclair · David Sinclair: Reversing the Aging Process · May 3, 2022 · at 6:14
Harvard geneticist Dr. David Sinclair explains the Information Theory of Aging, contrasting the static genome with the epigenetic control systems that determine cellular function over time.
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“Eventually born, and this epigenomic information that tells cells how to behave, we think breaks down over time, and that results in diseases, tissue dysfunction, so, you know, you start to look older, you can't clear toxins, you can't think well, your nerve cells don't work well, you become less able to see at night, eventually you get diseases that kill you, and that's really the major cause of suffering on this planet, and what we've done as a medical community Is to look at the end stage of this process, and we call these things diseases, and try to treat them with drugs and, you know, basically putting band-aids on the problem, forgetting what got us to that point in the first place, which is aging itself, which I have proposed and is increasingly thought to be the case, that it's disruption of that epigenetic control system that tells the cells which genes to turn on and off.”
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