Harvard geneticist Dr. David Sinclair discusses dietary impacts on aging and the mTOR pathway on The Knowledge Project with Shane Parrish.
Assertion Supported
Sinclair: Research shows cellular epigenetic aging damage can be reversed
“And what we've discovered is that there are ways to, well, we discovered one of the main causes of scratches, that's broken chromosomes, which happens all the time in our bodies. Extreme cell damage also does that if we crush nerves. But we've also figured out…”
Prediction Didn’t hold up
Sinclair: Team May Reverse Aging in Humans Within 18 Months
“In Canada, we have a non-human primate study for safety to see how that goes, and within the next 18 months, if all goes well, we will be reversing aging in a human, if all goes well.”
Assertion Not checkable as stated
Sinclair: Research Shows Interventions Can Make an 80-Year-Old Biologically 60
“We're keeping animals and increasingly we're showing with people that you can keep them younger for longer so that when you're 80, you can actually be 60.”
Prediction Open · timeframe May 2172
Sinclair: Someone Born Today Will Live to Be 150 Years Old
“But I do think that somebody born today
We'll live that long because the technology is just going so quickly.”
Assertion Supported
Sinclair: Sirtuin Gene Therapy Extends Mouse Lifespan in Lab Studies
“And there are seven of these epigenetic regulators, the things that prevent the scratches, and we can turn them on
With gene therapy.
In mice, we do this, and if you do it in the brain of a mouse, they'll live longer.
Do it in the body, they can live longer.”
Assertion Partly supported
Sinclair: Time-Restricted Feeding Extended Mouse Lifespan by 30% Regardless of Diet
“And there's a very famous study that was done by a colleague of mine, Rafael de Cabo at the NIH in Bethesda, and he made three different types of diets for mice.
One that had a lot of protein, the other had carbs, the other had fat, and he thought he would fin…”