The Ledger

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Disclosure
Bryan Johnson: 5-MeO-DMT was more efficacious than diet and exercise combined
“If I just subjectively compare my experience with five MEO to having a better diet and exercising every day and sleeping well and doing the sauna and doing hyperbolic oxygen therapy, this was more efficacious than all of them. In terms of the reset of me as a …”
Bryan Johnson Mar 26, 2026 ▶ 17:47 Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
Disclosure
Bryan Johnson created personal organoids to test longevity drugs in vitro
“We have the organoids stood up. We haven't done our first takes yet.”
Bryan Johnson Mar 26, 2026 ▶ 31:46 Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
Disclosure
Bryan Johnson: Psychedelics provided 30 to 40 years of psychological rejuvenation
“I felt like it was like 30, 40 years of Psychological rejuvenation. Like, you know, it's like to transform me back to a childlike state. That is insane. I don't get that from the sauna. Or from eating well. Or from sleeping well.”
Bryan Johnson Mar 26, 2026 ▶ 36:59 Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
Disclosure
Bryan Johnson: I achieved eight months of 100% perfect sleep scores
“I did eight months of perfect sleep. A hundred percent sleep every night to show I could do high quality sleep.”
Bryan Johnson Apr 3, 2025 ▶ 1:46:32 All-In Live from Austin: Colin and Samir, Chris Williamson, and Bryan Johnson
Disclosure
Bryan Johnson: Plasma exchange was driven by father's cognitive decline
“Yeah, you know, I did it because my dad was experiencing cognitive decline, and he called me in a panic, and he said, I will do anything to save my consciousness, and so I did it for him.”
Bryan Johnson Apr 3, 2025 ▶ 1:49:06 All-In Live from Austin: Colin and Samir, Chris Williamson, and Bryan Johnson
Disclosure
Bryan Johnson: Kernel scans show psilocybin generated new neural connectivity
“So you look at my brain on psilocybin from Kernel, you see my patterns before, like the New York to London connection. You see my brain afterwards, and it's exactly what you said. New patterns are emergent. The old ones have quieted down. It's like a new map o…”
Bryan Johnson Mar 26, 2026 ▶ 8:15 Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
Disclosure
Bryan Johnson: Blueprint targets mitochondrial rejuvenation after exhausting existing treatments
“We've knocked out all the stuff you can do today. Like we've gone through it all, done it all. The next gen therapies are just not there yet. So we're looking at mitochondrial rejuvenation.”
Bryan Johnson Mar 26, 2026 ▶ 26:48 Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
Disclosure
Johnson: Don't Die Certified aims to test 20% of top US foods
“We want to test 20% of the foods that make up 80% of the US diet, so then we can say, on average, the average American consumes blank, you know, mercury per day, or cadmium, or whatever.”
Bryan Johnson Apr 3, 2025 ▶ 1:39:09 All-In Live from Austin: Colin and Samir, Chris Williamson, and Bryan Johnson
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