The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 32 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 1 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Bryan Johnson: Gerber IP-blocks heavy metal test results outside California
“Yeah, I think the four, four big. And so it's like, okay, so go to Gerber's website, I can't find heavy metals results anywhere. And then I realized my VPN's on, and I'm coming from a server outside of California, they've IP blocked.”
Bryan Johnson: Most All-In Summit attendees have mental health issues
“And if we're honest, the majority of you in this room have some moderate to serious mental health problem.”
Bryan Johnson compares his 'Don't Die' movement to major world religions
“Don't die is the next major ideology on par with democracy, capitalism, Christianity, Islam.”
Bryan Johnson: Don't Die Certified found high glyphosate levels in diapers
“We looked at diapers. There was a dangerously high level of glyphosate in diapers.”
Bryan Johnson says psilocybin triggered a metabolic reset and microbiome shift
“What we found in psilocybin though, is it had, we found a first in human observation. It had this metabolic reset in the brain where my blood glucose before this was in the top. 99.5 percentile of all the population. Okay. After it went to the top 99.9 percent…”
Bryan Johnson: 5-MeO-DMT annihilates the default mode network compared to psilocybin
“Five MEO DMT compared to psilocybin, like just absolutely like blasted clean. My default mode network. It felt like psilocybin dampens it, like it softens it, but this thing just annihilated my default mode network.”
Bryan Johnson: 5-MeO-DMT was more efficacious than diet and exercise combined
“If I just subjectively compare my experience with five MEO to having a better diet and exercising every day and sleeping well and doing the sauna and doing hyperbolic oxygen therapy, this was more efficacious than all of them. In terms of the reset of me as a …”
Bryan Johnson: VCs put anti-psychedelic clauses in founder deal documents
“One investor told me that he even put it in the deal docs that, you know, if we invest, you're not going to do these psychedelics because they wanted to minimize the risk profile.”
Bryan Johnson created personal organoids to test longevity drugs in vitro
“We have the organoids stood up. We haven't done our first takes yet.”
Bryan Johnson: Psychedelics provided 30 to 40 years of psychological rejuvenation
“I felt like it was like 30, 40 years of Psychological rejuvenation. Like, you know, it's like to transform me back to a childlike state. That is insane. I don't get that from the sauna. Or from eating well. Or from sleeping well.”
Bryan Johnson claims he has the best health biomarkers in the world
“Basically, I have the best biomarkers of anybody in the world.”
Bryan Johnson: Managing resting heart rate before sleep is the best health habit
“So you guys, the single best thing I've learned out of everything I've ever done is your resting heart rate before sleep is the best thing you can do for your health.”
Bryan Johnson: Lowering pre-bed resting heart rate is top health metric
“So the key marker is lowering your resting heart rate before bed. That is the number, I'd say if you could mark, if you could optimize one marker in your entire life, it's that.”
Bryan Johnson: I achieved eight months of 100% perfect sleep scores
“I did eight months of perfect sleep. A hundred percent sleep every night to show I could do high quality sleep.”
Bryan Johnson: Plasma exchange was driven by father's cognitive decline
“Yeah, you know, I did it because my dad was experiencing cognitive decline, and he called me in a panic, and he said, I will do anything to save my consciousness, and so I did it for him.”
Bryan Johnson: Kernel scans show psilocybin generated new neural connectivity
“So you look at my brain on psilocybin from Kernel, you see my patterns before, like the New York to London connection. You see my brain afterwards, and it's exactly what you said. New patterns are emergent. The old ones have quieted down. It's like a new map o…”
Bryan Johnson: Blueprint rejuvenated heart and lungs, but brain is harder
“We've had a lot of success rejuvenating my heart and my lungs and muscle and body fat, but rejuvenating the brain is very hard.”
Bryan Johnson: FOXL-III stem cell therapy showed over 50% tissue rejuvenation
“So the mesenchymal stem cells, you know, packaged up with the FOXL-III delivery you know, that showed that over 50% of tissue is getting that rejuvenation.”
Bryan Johnson: New Limit computationally solved cellular reprogramming factor discovery
“They've done, I mean, they've made remarkable progress. They figured out how to computationally Solve the discovery process. And so they they're much faster than they initially thought.”
Bryan Johnson: GLP-1s and plasmid therapies will drive major longevity shifts
“In the future, like, I think we'll look back and we'll see GLP ones as the first big drop. Like what I can just inject myself and like it solves hunger and totally. Yeah. And then the second will probably be something like new limit or one of these Fox, one of…”
Bryan Johnson: Blueprint will surpass $100M revenue in under 12 months
“We'll beat a hundred million dollars in less than 12 months”
Bryan Johnson: CPG is the worst business model in the world
“CPG sucks. It's the worst business in the world.”
Johnson: RFK Jr. will challenge status quo power and force reconfiguration
“I think he is going to challenge status quo power. And I think that's going to create a lot of conflict and a lot of reconfiguration.”
Bryan Johnson: Sleep is the single biggest health optimization power law
“Sleep is, like, by far and away the biggest power law. Then exercise, number two, diet, number three.”
Bryan Johnson: Blueprint conducted the world's most quantified psilocybin experiment
“And so we did the world's most studied, the most quantified experiment doing psilocybin, three doses at 25 milligrams of psilocybin.”
Bryan Johnson: Blueprint targets mitochondrial rejuvenation after exhausting existing treatments
“We've knocked out all the stuff you can do today. Like we've gone through it all, done it all. The next gen therapies are just not there yet. So we're looking at mitochondrial rejuvenation.”
Bryan Johnson: Sprinting is an underappreciated longevity therapy
“Sprinting is one of the most underappreciated longevity therapies.”
Bryan Johnson: Developing in-house FOXL-III gene therapy is a two-year project
“That's like a two-year project.”
Bryan Johnson: Brain atrophy from aging reduces single-leg balancing ability
“As you age, part of your brain that keeps you well-balanced atrophies, and you can't maintain the balance very well, so kids are very good at this. As you age, you get worse, ok?”
Bryan Johnson's single-leg balance test benchmarks for determining biological age
“So, if you are, ah, between 15 and 30 seconds, that's roughly age 20 to 40. Seven to 15 seconds, you're between 40 and 60, and zero to seven, you're 60 plus. As an age category, ok?”