The Ledger

Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.

clear all ✕

why aren't all 6 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable

Prediction Didn’t hold up
Friedberg: 50 protein-folding startups will be funded in 12-18 months
“I think we're within, within one year, J. Cal, of a lot of startups replicating this alpha fold technique, and then using that to go do drug discovery, and you'll see 50 startups getting funded 12 to 18 months from now based on some novel protein idea.”
David Friedberg Dec 4, 2020 ▶ 46:12 E14: Salesforce acquires Slack, DeepMind’s AlphaFold breakthrough, Trust Fund Socialists & more
Prediction Held up
Friedberg predicts competitors will replicate DeepMind's AlphaFold within 24 months
“It's an inevitability that in the next couple of 24 months, someone else will replicate this.”
David Friedberg Dec 4, 2020 ▶ 41:00 E14: Salesforce acquires Slack, DeepMind’s AlphaFold breakthrough, Trust Fund Socialists & more
Assertion Supported
Friedberg: AlphaFold accuracy matches experimental microscopic measurement precision
“And the accuracy of their predictive model now is within the range of error of the microscopes that are being used to actually scan and measure those proteins.”
David Friedberg Dec 4, 2020 ▶ 31:31 E14: Salesforce acquires Slack, DeepMind’s AlphaFold breakthrough, Trust Fund Socialists & more
Assertion Supported
Hassabis: AlphaFold is a hybrid model incorporating physics and chemistry rules
“So AlphaFold itself is a hybrid model where you have the learning component, this probabilistic component you're talking about, which is, you know, based on neural networks and transformers and things, and that's learning from the data you give it you know, an…”
Demis Hassabis Sep 12, 2025 ▶ 26:53 Inside Google DeepMind: AGI, Robotics, & World Models Explained - Demis Hassabis
Assertion Supported
Friedberg: DeepMind's protein modeling led to dozens of startups and billions invested
“And there have been literally dozens of companies that have been started since DeepMind was published, and probably several billion dollars of capital that's gone into companies that are creating new drugs, creating new industrial biotech applications, using t…”
David Friedberg Oct 11, 2024 ▶ 33:08 Hurricane fallout, AlphaFold, Google breakup, Trump surge, VC giveback, TikTok survey
Assertion Partly supported
Friedberg: Harvard study combined X-ray imaging and AlphaFold to map nuclear pore complex
“What this team at Harvard did that they published two weeks ago is a really groundbreaking, extremely detailed view of the entire nuclear comp, nuclear pore complex, Around the nucleus of the cell by combining both x-ray imaging and alpha fold.”
David Friedberg Jun 30, 2022 ▶ 1:30:30 E85: SBF's crypto bailout, Zendesk sells for ~$10B, buyout targets, US diplomacy, AlphaFold & more
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