Patrick Collison: Evo 2 achieves state-of-the-art human mutation prediction from one human genome
Patrick Collison · The Stablecoin Future, Milei's Memecoin, DOGE for the DoD, Grok 3, Why Stripe Stays Private · Feb 22, 2025 · at 1:04:09
Patrick Collison discusses how the Arc Institute's Evo 2 model generalizes across species to predict human genome mutation risks.
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“It's trained on nine trillion base pair gene tokens. So, you know ChatGBT, LLMs are normally trained on, on, you know, the, on, on human language. This is a language model, but it's trained on, on DNA, the language of life. And there's only one human genome in the training set. It's mostly other species. And even though it's only seen one human genome, it's state of the art at predicting the pathogenicity of human genome mutations.”
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