Yamanaka factors
5 statements across 3 episodes · 5 bullish · 0 bearish · 2 people on the record · first statement Jan 27, 2023 by David Friedberg · across every show →
Everything said about Yamanaka factors, oldest first
Jan 27, 2023 positive
Oct 1, 2024 positive
Belmonte: Yamanaka factor pulses reverse diabetes symptoms in obese mutant mice
“If we just give a short pulse of these Yamanaka factors, we get this mouse. The mouse still keeps eating because it has the mutation. We haven't corrected. But the mouse now has less fat in the liver and can respond to glucose like a normal A young and healthy…”
Oct 1, 2024 positive
Belmonte: Exercise creates cellular gene expression changes similar to Yamanaka factor pulses
“We have compared what are the changes in the cell between exercise and the short pulses of Yamanaka factors. And you couldn't believe the similarities in the changes in gene expression that exercise does, and how overlap these changes happen when we do the Yam…”
Oct 1, 2024 positive
Belmonte: Short Yamanaka factor pulses alter chromatin while preserving cell identity
“Rather than having the factors for a long time, we just gave a short pulse. What that is doing is altering the chromatin, but for a very short time, it's a small shock, and then the chromatin gets closed and maintains its identity.”
Feb 28, 2026 bullish
Friedberg: Over a dozen startups are developing Yamanaka factor therapies
“There are now over a dozen startups that are trying to deliver Yamanaka factors, which are these proteins or some other sort of protein that can actually reverse aging by restoring the epigenome and cells and make them young again.”