The Ledger, every show

“Once AI becomes super intelligent, which should occur in like 20, 26 or something like that. If it hasn't already, I'm not kidding. I'm not saying this very soon. Once it's super intelligent and then by 20, 29, it's going to be like orders of magnitude smarter…”

“I think a lot of people aren't prepared for the mid to late 20 thirties, maybe even earlier, when the, when we just don't have old people anymore. We have people that are chronologically 57 years old, but biologically they look 22.”

“Why don't we just change the DNA so that our DNA creates a beautiful body for us in the probably late 20 thirties. That's going to be almost inevitable.”

“As a system is incremented up in intelligence and gets to human levels, high human levels, and then superhuman levels, alignment almost completely resolves itself.”

“These drugs are going to be Orders of magnitude safer and fewer side effects than anabolic steroids.”

“And then us uploading our brains into the cloud, living there for every Kurtzweil style, which I'm super down with. I think that's inevitable.”

“A few years later, People who have lost their arms through amputation, for example, of their legs, their replacement parts will be better than biological parts. Just better.”

“This is such a real thing that a large fraction of female athletes at the very top of their sports have trouble getting up for a competition, like waking up to try to do their best, especially in very sports which require confrontation, jujitsu, wrestling even…”

“We're going to have this, I predict very confidently in the late 20 twenties, especially through the 20 thirties, we're going to have a drug Renaissance where they're going to be able to make drugs that are incredibly targeted at one specific thing. They're go…”

“So this idea that corporations intentionally, pharmaceutical corporations are intentionally keeping people sick is baffling and wrong”

“There's actually only one reason housing is expensive. Pure regulation.”

“The COVID vaccine situation was largely uncontroversial, insanely effective, and saved probably twenty million lives worldwide.”

“It, it's like quaternary if I had to put it. I mean, it just matters in such nuanced ways that there are like 10 things that matter more. The total effect magnitude of when you space your meals is teeny tiny. A lot of people in the fitness industry like to maj…”

“If you have a few drinks now and again, it has Literally no statistical impact on longevity or quality of life or anything like that.”

“As far as nicotine, nicotine is actually like pretty close to a true nootropic, which means it elevates your ability to think clearly and stay focused and all that stuff.”

“Smoking is bad almost exclusively because you're smoking. Tar and all that stuff. If you take smoking here as a negative, nicotine pouch is right here, and a lot of people have this false equivalency idea of like, well, it's anything nicotine is bad. Relativel…”

“So testosterone is one of those things that if you're older, if you're in your late thirties, forties, and so on, and blood tests confirm that you're on the low end and you have the symptoms of low testosterone, it is a very good idea to get testosterone repla…”

“But for most people, their testosterone is totally fine and absolutely not even close to the limiting factor on how they feel and their longevity and quality of life.”

“What do you go, how do you fight AI with just straight up better AI? And because we have free markets, because we have really good people, and because we have a fuckload of infrastructure, RAI's just gonna be smarter by orders of magnitude than the bad AI.”

“I would say do not take anabolic steroids. You can look at testosterone replacement therapy to take you to the high and normal range of testosterone production.”

“I think Brian Johnson has a very unconventional view, but I think Brian Johnson is prescient, and I think his view that we may never have to deal with death in the conventional sense or aging in the conventional sense is going to be something that Even by the …”

“Exercise machines like leg presses and hack squats, they're like the biggest revolution for those was in the eighties, and to some extent have arguably gotten worse since then.”

“Over time, specifically after roughly the 19 fifties and moving up in an exponentially increasing curve. What you could call the price palatability of food has skyrocketed.”

“The biggest factor of who's getting super obese and who's not is probably just people's genetically determined, largely genetically determined baseline hunger signaling and food pleasure response.”

“Mexico's income per capita is now similar to what the US income per capita was in the 19 sixties. It is no longer accurate to call Mexico a third world country or a poor country. Almost no one there is poor. Food insecurity is an incredibly unlikely thing in M…”

“Technically it's a third generation GLP drug, but fourth gen is Trisapatide. It's already on the market, Manjaro. Fewer side effects, bigger primary effect. There are fifth gen drugs currently in FDA approval process, which make Ozempic look like a starter pac…”

“They actually lower your addictive drive to almost everything. People like quit smoking. They're quitting drinking on these drugs. They're, they stop biting their nails and stuff.”

“Corporations do not want you to be fat. Not in the least. It turns out there's no, they want to be rich. And how do they get rich? They give you what you tell them you want. Not verbally with your dollars.”

“That's very likely, yeah. The effect might, in some people, be profound, where, like, they started their jaw stuff, and, like, a few months later, like, oh my god, like, Tony Dan's, that kind of thing, hanging out.”

“If you have one or two glasses of wine a night, most nights, Statistically, it has almost no effect on anything negative-wise.”

“There's physical addiction, which is, like, if someone just stops doing heroin, they have to be supervised, otherwise they could die, and they have, like, crazy fevers and all this other hallucinations, and once you're over the hump, like, you're fine, but the…”

“The average person, if they're eating a decently well-balanced diet, just doesn't need any supplements. Of any kind.”

“Most pre-workouts are in my opinion, like wildly overdosed.”

“There's a supplement called it was a jacked three D that was the old formula prior to like the 2015 or something. And that legitimately had a version of methamphetamine in it.”

“It turns out that people live to older age so much more now that they live long enough to get cancer.”

“Many of the people who are anxious are precisely the people for whom life is the easiest.”

“If you do a million crunches, your body fat on your abs will go away, which does not happen. It's all almost all systemic.”

“Another one is that if you do lots and lots of cardio, you'll lose like an unbelievable amount of weight. And that's also not true because the biggest variable for weight control is your diet and not cardio.”

“Because it seems to be that when muscles are put under tension and stretch at the same time, they grow more.”

“And then the other piece of advice is that if you eat a healthy, high protein diet and control your calories, that plus this kind of resistance training is like 80% of all of health and fitness.”

“If you drink three to four and more drinks most nights, you're going to be paying a small health and longevity downside. And then the negatives exponentially accelerate. After that.”

“Another one is obesity. Radically decreases testosterone levels.”

“As everyone gets wealthier, and the problems of the world are beginning to be more tractable. AI is helping a lot there. I think there's going to be a turn inwards to where people want to look better, feel better, live longer, be healthier, and also work on th…”

“As these drugs gain maturity and evolve over time, you're basically going to have a turn dial for people to lose as much fat and much weight as they want. And there are many different kinds of classes of drugs that are currently in development, currently in hu…”

“Peptides don't grow much muscle. They do help with some kind of joint healing properties. They have fat loss properties.”

“There are currently drugs in stage two clinical trials. One of them I know is by Regeneron Pharmaceuticals. It's an activin and myostatin dual antagonist”

“This kind of stuff helps and it definitely helps in, in context, slow the aging process, but the epigenetic, genetic modification, drug-based modification, that's the real tidal wave. We're just swimming in a puddle right now.”

“New medications like Ozempic, Trisapatide, et cetera, Manjaro, all those things. While, why they were some of the only things to really take a big chunk out of obesity is because they take your, whatever genetic food drive and palatability drive you have, how …”