Sirtuins
topic on 1 show · 5 statements across 2 episodes
5 statements about Sirtuins, every show
Sinclair: Sirtuin Gene Therapy Extends Mouse Lifespan in Lab Studies
“And there are seven of these epigenetic regulators, the things that prevent the scratches, and we can turn them on
With gene therapy.
In mice, we do this, and if you do it in the brain of a mouse, they'll live longer.
Do it in the body, they can live longer.”
Sinclair: NMN Supplementation Has Prevented Jet Lag for a Decade
“I haven't had jet lag for a decade because I've been able to modulate my own body clock by using these chemicals, which as I mentioned are activating sirtuins and controlling the clock.”
Sinclair: Stressed Plant Molecules Activate Human Longevity Pathways
“What we've realized is that in addition to be being antioxidants, they actually turn on those longevity pathways, the sirtuins.
They work on mTOR.
There's another one called AMPK, which senses blood sugar and energy.
And by eating plants that in general
Make t…”
Sinclair: Olive Oil and Red Wine Compounds Activate Sirtuins to Improve Health
“And there are actually chemicals within those foods of a Mediterranean diet in olive oil and red wine. That we found in my lab to activate these sirtuins and probably also slow down the clock, but they certainly improve health.”