The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 684 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Bilgen: BillionToOne Processes Over 600,000 Tests Annually With ~20% Market Share
“We are processing more than 600,000 tests a year, and in terms of the overall market share, We are close to 20% market share there.”
Friedman: Most genetic abnormalities previously required invasive amniocentesis for detection
“Before Billion to One, most genetic abnormalities could only be detected via amniocentesis, an invasive procedure that is only used in high-risk pregnancies.”
Bilgen: Fetal and tumor cell-free DNA are fundamentally identical to detect
“And, you know, we realized that, you know, fundamentally there is nothing different about, you know, cell-free fetal DNA and cell-free tumor DNA, and the same technology can be applied to both of them.”
Mellata: Variance Reviews GoFundMe Fundraisers and Fortune 50 Seller Verifications
“We've been working with GoFundMe, for instance, to review all of their fundraisers at scale, some Fortune 50 for verifying all of their sellers and complex UBO verifications, and today coming out of stealth.”
Mellata: GoFundMe uses Variance AI agents for fraud and sanctions compliance
“So Variance is used to verify, for instance, if a fundraiser is going to be built for A military operation, for instance, or if you're building a fundraiser for a crisis that you were not part of, which would be fraudulent, well, GoFundMe sort of has the respo…”
Mukund Jha: Hundreds of AI agents will collaborate on single tasks by year-end
“I think by end of the year you'll have, you know, agents which are running for hours. And like maybe hundreds of agents collaborating on the single task.”
Hodak: Science completed clinical trial published in NEJM in 2025
“We finished a big clinical trial last year, which was published in the New England Journal of Medicine in the fall.”
Hodak: Current cortical motor decoders achieve only around 10 bits per second
“Spoken word is like 40 bits per second. You can, many people can type in the like 20, twenty-ish bits. And so the 10 bit per second cortical motor decode is like not going to make your life better. I wouldn't get serious brain surgery for that.”
Adults cured of congenital cataracts struggle to process visual information
“There actually are some cases of patients that were born blind who but it wasn't it wasn't a loss of the optic nerve, it wasn't something in the brain, but they had congenital cataracts, so their vision was blurry from birth, and they were never able to really…”
Friedman: Moltbook saw more content in two days than early Reddit
“Like I don't have the Reddit traffic stats, but my guess is like more content was posted on Maltbook in the first two days and was posted on Reddit in like the first two years or something.”
Steinberger: Major AI platforms lock user memory data into proprietary silos
“There's no, there's, definitely there's no way for a different company to get your memories out. So if I was like a company who like provides chat services, You could use me, but then I couldn't access the memories. So, like, the companies try to, like, bound …”
PostHog raises a $75M Series E at a $1.4B valuation
“James is here hot off the news of raising a seventy-five million Series E round of funding at a 1.4 billion dollar valuation, making PostHog the latest YC unicorn.”
Skates: Amplitude generates $350M in annual revenue and spends nearly that much
“We're three hundred and fifty million in revenue, and, you know, we're deploying close to that in terms of total spend every year”
Pollak: Base Compresses Transactions to Ethereum to Slash Costs 1,000%
“So what base does is you can kind of think about it like an HOV lane. We sit on top of Ethereum. We take millions and millions of transactions. We compress them and we publish them to Ethereum. And that means that when we're compressing them, we can get a ton …”
Pollak: Entrepreneurs are launching native fiat stablecoins across emerging markets
“Now alongside the dollar stable coins, you actually have entrepreneurs in all those countries who are creating stable coins for their currencies. So you have a Brazilian real currency. You have a Nigerian Naira currency. You have an Indonesia rupee currency. Y…”
Pollak: Developers Are Bringing Stocks, Bonds, and Debt Onto Base
“And that's what we're seeing every day on base right now. It's like people are bringing stock, they're bringing bonds, they're bringing more stable coins, like I talked about earlier, they're Actually, you know, bringing collateralized debt positions. Like, ev…”
Pollak: Every post and creator on Base app is a coin
“On the base app, it's a new social product where every single post that you make is a coin and every single creator is a coin.”
Friedman: Over 100 YC startups hiring forward deployed engineers
“I was looking earlier today, and if you look at the YC job board, there's over a hundred YC startups that are hiring for a job with the title for deployed engineer and up from basically zero, three years ago”
McGrew: Palantir CTO Shyam Sankar invented the FDE strategy
“And I think this is where Shamsankar, who's very early employee, you know, now that I think the president and CTO of Palantir, he really invented the FDE strategy.”
Dylan Field: Figma announced acquisition of Payload CMS
“In terms of open source, we actually just announced today the acquisition of Payload CMS, which is an open source project, and I'm really excited about what we can do there and how we can support open source more.”
Kaplan: Claude 4 will store and retrieve memories across context windows
“Claude IV can blow through its context window with a very complex task, but can also, ah, store memories as files or records, retrieve them in order to sort of keep doing work across many, many, many context windows.”
Finn: Architectural fix boosted robot language following rate from 20% to 80%
“And second, it also followed language far better an 80% follow rate rather than a 20% follow rate which suggests that we're able to preserve the kind of pre-training in the vision language model backbone.”
Jumper: AlphaFold 2 architecture on 1% of data matched AlphaFold 1
“The Al Qureshi lab, did a very, ah, careful experiment, where they took AlphaFold II, the architecture, and they trained it on one percent of the available data. And they could show that alpha fold two trained on one percent of the data was as accurate or more…”
Jumper: AlphaFold had one-third the error of any CASP competitor
“And we had about a third of the error of any other group on this assessment.”
Srinivas: Sundar Pichai is personally doing bug support on X
“Like I've noticed even Sundar is doing bug support on X right now.”
Chollet: Every High-Performing ARC AI Method Uses Test-Time Adaptation
“And today, every single AI approach that performs well on Arc is using one of these techniques.”
Fei-Fei Li: AlexNet was the first time two GPUs powered deep learning
“It's not just convolutional neural network. It was also the first time that two GPUs were put together by Alex and his team. And were used for the computing of deep learning. So, it was really the first moment of data, GPUs, and neural network coming together.”
Nadella: World Bank study found AI copilots are top education tech intervention
“By the way, one of the other ones, since you brought it up, there was a World Bank study they did, I think in Nigeria, and now they've taken it to Peru or Chile, one of those in South America. It's, you know, we've been working at Microsoft forever on can ther…”
Altman: OpenAI's o3 model cost dropped by 5x in one week
“And also, like last week, O-three cost five times as much as it did this week, and that's gonna keep going.”
Musk: Five humans have received Neuralink implants
“We have now five humans who have received the kind of the read where it's reading signals, and you've got people with ALS who really have no, they're tetraplegics, but they can now communicate at, with Similar bandwidth to a human with a fully functioning body…”
Tesla Autopilot neural networks systematically replaced explicit C++ code
“As we made the autopilot better, basically the neural network grew in capability and size, and in addition to that, all the C++ code was being deleted and kind of like was And a lot of the kind of capabilities and functionality that was originally written in o…”
Tan: Cursor Reached $100M ARR in 20 Months at $9B Valuation
“They recently hit a nine billion dollar valuation and are one of the fastest growing startups of all time, reaching a hundred million dollars ARR just 20 months after launching.”
Palicha: Zepto raised $9M, $50M, and $100M rounds in four months
“But even from a capital perspective, we went from, like, effectively the hundred, 125 K from YC to, like, a nine million dollar round To a fifty million dollar round to a hundred million dollar round in like four months.”
Thompson: GLP-1 Drugs Linked to Lower Dementia Rates in Veterans Study
“I did on my podcast, Plain English, an interview with someone who, ah, did this observational study, this population research on millions of people in the Veterans Affairs system who have been on GLP-I drugs for their type one, type two diabetes, or on other d…”
Xu: DoorDash has over 7 million drivers; nearly 60% are women
“Today, DoorDash has over seven million drivers in on the platform. Of these dashers, the drivers on the platform, almost 60% are women.”
McGrew: OpenAI authored early robotics paper as 'OpenAI' to avoid credit disputes
“And one of the early robotics papers, we actually said site as open AI because we didn't want to get into a fight. You know, the first author is the one who, you know, gets cited and their name shows up every single time. So we said, you know, we're not going …”
Zaparde: Zip reaches 350 employees and $2.2B valuation after Series D
“Yeah, so the company is about 300 fifty-ish people we've raised about three hundred seventy million dollars now, and the most recent round was our Series D at 2.2 billion post last month.”
Dessaigne: Dozens or Hundreds of Startups Are Building LLM Observability
“Many other companies think the same thing, and that's why we have dozens, if not hundreds, Of such companies out there.”
Friedman: Full OpenAI o1 Model Is a Huge Step Function Above o1-Preview
“Like the full O-one model, which is coming out any day now is a huge step function above even O-one preview, which is what enabled all these incredible results at the hackathon.”
Altman: OpenAI's GPT Series Originated From Radford's Unsupervised Sentiment Neuron Discovery
“And at the time, unsupervised learning was just not really working. So he noticed this one really interesting property, which is there was a neuron that was flipping positive or negative with sentiment. And yeah, that led to the GPT series.”
Hu: DoorDash built its initial product in one afternoon using Google Drive
“DoorDash, as a product, was built in one afternoon. Whether you believe it or not, the tech stack was basically Google Drive to upload the menus. HTML, CSS for putting the menus. The phone was Tony's phone.”
Hu: Seven 'Attention' authors founded startups collectively valued over $6B
“That paper came out in 2017, and the fun fact, I was just looking this up, out of all those authors, eight authors, seven of them started different companies, and all of the companies in total, they're rate, they're worth valuation more than six billion.”
Caldwell: Space launch costs are falling along a Moore's Law curve
“The cost per pound to put something in space, and it looks like Moore's law, where what's happening is that there's this Moore's law looking graph on how cheap How much cheaper it is getting to put something into orbit.”
Flora: Asher Bio raised its first $1M on SAFEs with an idea
“The founders of Asher came into YC with just the idea. And they were able to raise the first round of funding using safes quickly from angels. This is pretty novel for a biotech company. And using that first million or so that they raised, they could accelerat…”
Flora: Zapier reached $100M in revenue having raised money only once
“And today that's a hundred million dollar revenue business. And they only raised money that one time.”
Habib: Fine-tuning is what separated ChatGPT from earlier GPT models
“If you look at what the difference is between ChatGPT or the most recent OpenAI Text DaVinci Three model, and what's been in the platform for two years and has not gotten as much attention, the difference is fine tuning. Like it's the same base model, more or …”
Habib: Anthropic matched RLHF performance using AI-generated feedback
“Anthropic had this very exciting paper just a couple of weeks ago where actually we're able to get similar results to RLHF without the H. So just actually having a second model provide the evaluation feedback as well. And that's obviously a lot more scalable.”