The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
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Sinclair: Research shows cellular epigenetic aging damage can be reversed
“And what we've discovered is that there are ways to, well, we discovered one of the main causes of scratches, that's broken chromosomes, which happens all the time in our bodies. Extreme cell damage also does that if we crush nerves. But we've also figured out…”
Sinclair: Team May Reverse Aging in Humans Within 18 Months
“In Canada, we have a non-human primate study for safety to see how that goes, and within the next 18 months, if all goes well, we will be reversing aging in a human, if all goes well.”
Sinclair: Data Shows Carnivore Diet Does Not Promote Long-Term Longevity
“I'm convinced and the data shows it from population studies that a carnivorous diet isn't a longevity producing diet in the long run, right?”
Sinclair: Sirtuin Gene Therapy Extends Mouse Lifespan in Lab Studies
“And there are seven of these epigenetic regulators, the things that prevent the scratches, and we can turn them on
With gene therapy.
In mice, we do this, and if you do it in the brain of a mouse, they'll live longer.
Do it in the body, they can live longer.”
Sinclair: Time-Restricted Feeding Extended Mouse Lifespan by 30% Regardless of Diet
“And there's a very famous study that was done by a colleague of mine, Rafael de Cabo at the NIH in Bethesda, and he made three different types of diets for mice.
One that had a lot of protein, the other had carbs, the other had fat, and he thought he would fin…”
Sinclair: Slowing US Aging by One Year Saves $86 Trillion
“They calculated that the US alone, just by slowing down aging by one year, and making people productive, more productive for one year, would save over the next three decades, 86 trillion dollars, which we waste now on just keeping people alive in a sick state …”
Sinclair: NIH study found daily feeding windows extended mouse lifespans by 30%
“And there's a very famous study That was done by a colleague of mine, Rafael de Cabo at the NIH in Bethesda, and he made three different types of diets for mice. One that had a lot of protein, the other had carbs, the other had fat, and he thought he would fin…”
Sinclair: Recommended longevity habits add 14 to 15 years of life
“Just by doing the things that I'm talking about today, you'll get an extra 14, 15 years on average.”
Sinclair: One Gram of Daily NMN Raises Blood NAD Levels
“And I know from clinical trials that I've been involved with that taking a gram of NMN, which I do every day, raises NAD levels in whole blood, in the cells in the blood, probably in the rest of my body as well.”
Sinclair: Diabetics on Metformin Outlive Healthy Non-Diabetics
“By looking at type two diabetics, and there's a stunning, stunning fact, that type two diabetics that would normally have a short lifespan, when they take metformin, typically at two grams a day, I'm on one gram a day, by the way, they actually have less disea…”
Sinclair: Hip fracture mortality in elderly matches late-stage cancer
“The chances of dying after you break your hip as an older person is about as bad as late stage cancer.”
Sinclair: 80% of human longevity is lifestyle, only 20% is genetics
“80% of our longevity
And our health in the future is in our own hands.
Only 20% is genetic, which we cannot yet do much about.”
Sinclair: Combining exercise and NMN doubled running endurance in mice
“In the animal studies in my lab, when we gave NMN, this molecule that I take every day, to a mouse that was sedentary, didn't have a wheel, didn't run, it could run further, ok?
And we actually have human data that's looking really promising in that direction …”
Sinclair: Olive Oil and Red Wine Compounds Activate Sirtuins to Improve Health
“And there are actually chemicals within those foods of a Mediterranean diet in olive oil and red wine. That we found in my lab to activate these sirtuins and probably also slow down the clock, but they certainly improve health.”
Sinclair: Cellular Autophagy Requires Three Days of Fasting to Activate
“But once you've gone more than three days, there's a special type of recycling of proteins that's very beneficial called autophagy or autophagy. And that takes about three days.”
Sinclair: Research Restored Eyesight and Reversed Aging in Mice
“About a year ago, we published that we could reverse the age of an animal. And we restored eyesight to a blind old mouse and cure glaucoma in that animal.”
Sinclair: 100,000 People Die Worldwide Every Day From Aging-Related Causes
“Every day over a 100,000 people die from aging itself”
Sinclair: Sirtuin Gene Therapy Extends Lifespan in Mice
“In mice, we do this, and if you do it in the brain of a mouse, they'll live longer. Do it in the body. They can live longer, but we can't genetically modify ourselves.”
Sinclair: Hunger Cravings Subside After Three Weeks of Fasting
“Now, if you start fasting, and you've never done it before, you will feel hungry. There's a hormone called ghrelin, which will cause that. Of course, it's not real. Hunger is just mental state, but after three weeks, you find, I found, that the state of hunger…”
Sinclair: Having a reliable partner is among the top drivers of longevity
“It's been shown by studying hundreds of people over their lifetimes that one of the most important, if not the most important factor, is to have a reliable partner. A pet can substitute for that if you don't have one of those at the time. But yeah, you want co…”
Sinclair: High Lp(a) affects ~30% of people and reduces lifespan
“LP little a is the worst. You know, about 30% of us have this, and we're destined, if we don't do something, to have a short lifespan.”
Sinclair: Rapamycin extends animal lifespan even when started late in life
“There are animal studies you can, I could point to that show that you can have, affect this mTOR pathway with a drug called rapamycin that extends their lifespan, even if they're the equivalent of 70 years old.”
Sinclair: Depriving rats of sleep for two weeks causes diabetes
“If you stop a rat from sleeping for just two weeks, it will develop diabetes.”
Sinclair: Finnish studies show sauna bathing dramatically protects heart health
“There's now a lot of evidence that being in a sauna is good for heart health at a minimum. There's a lot of studies of thousands of mostly men in Finland that do sauna bathing, as they call it. And they are protected dramatically, like they are exercising.”