Mar 26, 2025 · 1h 22m · bigdeal
Ozempic Expert: They’re Lying To You About Getting Fat | Dr. Tyna Moore
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In this episode of The Big Deal Podcast, host Codie Sanchez interviews Dr. Tyna Moore to examine the science of metabolic health, demystify GLP-1 peptides, and emphasize resistance training and hormonal resilience over dogmatic wellness trends. Dr. Moore delivers actionable, evidence-based frameworks to help individuals reverse metabolic dysfunction, manage cortisol, and take radical personal accountability for their longevity.
How this conversation actually went
Every chapter scored 0–10 on four independent dynamics. Hover any point for the reasoning behind the score. Codie holds 26.9% of the talking time here. How this is scored →
Codie as informed peer 3.6 Guest teaching 5.9 Guest disagreement 2.4 Codie pushing back 0.4
speaking balance: gold is Codie, purple is the guest (3 minute bins)
Sharpest disagreement ▶ 52:41 Calling Out Peptide Influencer Hypocrisy
Dr. Tyna aggressively attacks a doctor influencer who built an audience bashing GLP-1s while commercially marketing BPC-157 peptide pills.
Hardest push from Codie ▶ 5:45 Challenging Overcomplicated DietingCodie uses a humorous dog feeding analogy to question whether health optimization is truly complex or just basic caloric restriction and walking.
Biggest teaching moment ▶ 45:38 Reframing GLP-1s as Regenerative PeptidesDr. Tyna educates the audience and host by detailing how GLP-1s function as systemic signaling peptides rather than simple appetite suppressants.
Codie holds their own ▶ 27:11 Citing Proximity Productivity DataCodie showcases her own research background by quoting precise asymmetric performance statistics regarding seating proximity to high vs low performers.
the scores for every segment, with the reasoning behind each
| Chapter | Topic | Codie as informed peer | Guest teaching | Guest disagreement | Codie pushing back | Why |
|---|---|---|---|---|---|---|
| Episode Preview and Core Health Theses | 3 | 3 | 1 | 0 | Codie opens the episode framing the conversation around walking the walk and asks Dr. Tyna about her journey from pack-a-day smoking to functional medicine. Dr. Tyna explains her transition and why she started training for menopause before age 40. | |
| Metabolic Syndrome and Balancing AMPK vs. mTOR Pathways | 3 | 6 | 2 | 1 | Codie questions whether weight loss can simply be reduced to eating less and walking more. Dr. Tyna reframes the debate by breaking down the biochemical interplay between the catabolic AMPK and anabolic mTOR pathways. | |
| Dietary Nuance, Protein Targets, and Carnivore Pitfalls | 3 | 7 | 2 | 1 | Codie asks about the inverted food pyramid model. Dr. Tyna explains that strict carnivore diets can induce insulin resistance and outlines optimal protein targets (1g per pound of body weight). | |
| Understanding Sarcopenia and Modulating Exercise for Women | 4 | 7 | 2 | 1 | Codie asks for a clear definition of sarcopenia. Dr. Tyna explains the difference between sarcopenia and cachexia, warning that high-intensity workouts like Orange Theory can elevate cortisol and backfire in aging women. | |
| Managing Cortisol, Sprint Intervals, and Individual Tolerance | 4 | 6 | 1 | 0 | Dr. Tyna details sprint interval training protocols and how unmanaged cortisol degrades muscle tissue. Codie inquires how women can accurately gauge if a workout aligns with their recovery capacity. | |
| The Hormesis Principle, Refeeding, and Strategic Recovery | 3 | 6 | 1 | 0 | Dr. Tyna introduces hormesis as strategic stress paired with deliberate recovery and refeeding. Codie affirms the relief of rejecting constant hustle culture in favor of structured restorative balance. | |
| The Protective Value of Body Fat and Estrogen Stores | 4 | 7 | 2 | 0 | Dr. Tyna explains why retaining some body fat is essential for women entering menopause, as fat stores produce estrone after ovarian decline. Codie connects this to evolutionary fertility cues. | |
| Hormonal Shifts with Age and the Mental Power of Deadlifts | 4 | 6 | 2 | 1 | Codie asks if metabolism inherently slows with age. Dr. Tyna cites data showing metabolic rate remains stable while estrogen loss reduces stress tolerance, emphasizing heavy deadlifts for nervous system regulation. | |
| The Contagious Nature of Microbiomes and Social Circles | 6 | 5 | 1 | 0 | Dr. Tyna explains how microbiomes and metabolic states are communicable between cohabitants. Codie demonstrates domain knowledge by citing specific studies on productivity contagion within a 25-square-foot radius and divorce trends. | |
| Setting Social Boundaries and Female Evolutionary Dynamics | 4 | 4 | 2 | 1 | Codie and Dr. Tyna discuss the necessity of pruning social circles to protect health habits. Dr. Tyna brings up a study on female intrasexual competition, and Codie humorously agrees with the evolutionary premise. | |
| Navigating Envy and Turning Peers into Expanders | 3 | 2 | 0 | 0 | Codie candidly shares an instance of jealousy toward a peer and how addressing it openly turned that peer into an expander. Dr. Tyna shares a parallel experience with business launches. | |
| The Root Causes of the Modern Infertility Crisis | 4 | 7 | 4 | 1 | Dr. Tyna outlines the multivariable causes of declining fertility, including thyroid dysfunction, environmental toxins, plummeting male testosterone, and widespread metabolic collapse. Codie notes the overwhelming majority of her peers utilize IVF. | |
| Medical System Incentives and Global Demographic Shifts | 4 | 6 | 4 | 0 | Dr. Tyna criticizes the medical system for defaulting to IVF as a lucrative hammer without addressing root metabolic health. Codie connects the demographic trend to broader warnings regarding population collapse. | |
| Demystifying GLP-1 Peptides Beyond Weight Loss | 3 | 8 | 5 | 0 | Dr. Tyna demystifies GLP-1s, explaining that they are signaling peptides with systemic neuroregenerative and anti-inflammatory properties rather than simple appetite suppressants. She recounts fierce pushback and debates across polarized camps. | |
| Social Media Censorship, Patient Cases, and Peptide Hypocrisy | 4 | 7 | 6 | 0 | Dr. Tyna recounts being deplatformed on social media after presenting published data on semaglutide. She sharply calls out the hypocrisy of anti-Ozempic influencers who simultaneously sell peptide supplements like BPC-157. | |
| Pharmaceutical Monopolies, Compounding, and Microdosing | 4 | 8 | 4 | 1 | Dr. Tyna discusses pharmaceutical patent disputes against compounding pharmacies and explains why standard commercial pen doses cause severe side effects compared to microdosing strategies. | |
| Standard of Care Limitations vs. Functional Cycling | 4 | 8 | 4 | 1 | Dr. Tyna contrasts allopathic rigid standard of care requirements with functional medicine cycling protocols. She warns that high-dose, long-term GLP-1 usage without strength training leads to severe lean tissue wasting. | |
| Physician Burnout, Patient Resistance, and Gut Support | 5 | 7 | 4 | 1 | Codie explains her brother's chronic GI and cyclical vomiting issues and standard medicine's tendency to prescribe psychotropic drugs. Dr. Tyna explains structural time constraints on physicians and recommends digestive enzymes, ox bile, and HCl. | |
| Catalysts for Health: Starting in the Gym and on the Plate | 4 | 6 | 2 | 0 | Dr. Tyna argues that true lifestyle transformation is typically catalyzed by hitting a wall of pain or vanity, noting that regular gym habits naturally cascade into better nutrition and sleep choices. | |
| Leading by Example and Personal Health Accountability | 3 | 5 | 2 | 0 | Codie asks how to support resistant family members. Dr. Tyna emphasizes that one cannot force change and must simply model healthy behaviors, concluding with radical personal accountability. | |
| Key Longevity Pillars: Hormones, Peptides, and Stress Control | 3 | 7 | 2 | 0 | Dr. Tyna provides actionable longevity advice for high performers, advising early hormone monitoring, peptide literacy, and aggressive chronic stress reduction to avoid metabolic decline in their late forties. | |
| Dr. Tyna Moore's Educational Platforms and Resources | 1 | 1 | 0 | 0 | Dr. Tyna shares where listeners can find her educational resources, reads a brief reflective letter to her younger self urging less stress and more joy, and Codie delivers the closing call to action. |
Statements from this episode (37)
Codie Sanchez: Doctors advising on health should visibly look fit
“Like if people are healthy, it doesn't mean hot, like you have to look like Kim Kardashian, but like healthy and fit and talking to us about being healthy and fit, you should probably look the fucking part. Is that a crazy thing to say that like doctors should…”
Dr. Moore: Today's youth drink far less alcohol than previous generations
“I don't think that today's young people are drinking nearly as much, but when I grew up, everybody was drinking, particularly in places where there was nothing else to do”
Dr. Moore: 94% of US adults suffer from cardiometabolic compromise
“We have 20 18 stats that were published in 2021 showing that close to, I think, 90 four percent of U.S. Adults have cardiometabolic compromise.”
Dr. Moore: High-dose GLP-1 medications trigger problematic muscle wasting
“This is where I think high dose GLP one comes into being a problem is it revs the AMPK.”
Dr. Moore: Excessive carnivore diets can induce insulin resistance
“You can over carnivore yourself into insulin resistance. High levels of arachidonic acid can send you into insulin resistance as well.”
Dr. Moore: Women inevitably develop greater insulin resistance with age
“As we age as women and we lose our estrogen stores, we become more insulin resistant period. And the more muscle mass we lose with age and atrophy, because that's just a normal part of aging as we start to atrophy everywhere. That we will become more insulin r…”
Dr. Moore: High-intensity workouts become less effective during menopause
“I think women in particular, they think, okay, orange theory, CrossFit, I'm going to hit it hard. As we get into menopause, that becomes less the success rate goes down there.”
Dr. Moore: Excessive workout intensity elevates cortisol and degrades muscle
“Cortisol is also catabolic. Cortisol chews up your tissues. So if we're cranking cortisol in the gym, but we're trying to gain muscle, you can see where intensity needs to be dialed in for the individual.”
Dr. Moore: Workouts should leave you energized, not completely exhausted
“I think you should feel better when you leave the gym than you came in. You should feel invigorated. You should feel like you got a boost. You should feel like it's going to carry you through your day. You should feel like your mood's improved. You should not …”
Dr. Moore: Intermittent fasting and high-intensity training cause weight gain
“If you're a middle-aged woman, you're stressed out of your mind, you're insulin resistant by nature because your hormones are waning. Now you're trying to do these long, intermittent fasts. You're trying to do hardcore intensity training because you're like, I…”
Dr. Moore: Hormetic stress requires rest and refeeding to be therapeutic
“The key to hormetic stress is to rest the organism after and refeed.”
Dr. Moore: A celebratory glass of wine might actually lower cortisol
“A glass of wine to celebrate might actually lower your cortisol and allow you to have a happier homeostasis inside your body.”
Dr. Moore: Extreme leanness in women is not optimal for longevity
“Keeping that super shredded look as a woman, I don't think it's great for longevity.”
Dr. Moore: Women tolerate stress and sleep deprivation worse than men
“Women do not tolerate stress the way men do. Women do not tolerate lack of sleep the way men do. Women do not tolerate You know, consistent intensity the way women are sorry, men do.”
Dr. Moore: Lifting weights is non-negotiable for aging without injury
“This is non-negotiable if you want to age well. And you, it's not about looking hot. It's about not breaking a hip.”
Dr. Moore: Lift weights and sleep before making any major decision
“If I have to make a big decision about something, I will lift and then I will sleep. Before I decide anything, and then when I wake up, it's usually the same decision I came to before that. But I promise myself that I will exhaust my nervous energy, I will sle…”
Dr. Moore: One person's antibiotics shift the entire household's microbiome
“He was sharing that a study a few years ago where one person in the family took an antibiotic and the entire family's microbiome shifted within days.”
Codie Sanchez: Sitting near a high performer boosts productivity by 15%
“There's great Studies that show that your productivity increases by about 15% if you sit in a 25 square foot radius of another, of a high performer, and it decreases by about 30% if you sit next to a underperformer.”
Codie Sanchez: Close social ties getting divorced increases personal divorce risk
“Your likelihood of getting divorced increases if you are around people in quite close that get divorced.”
Dr. Moore: Five obese online friends exponentially increases your obesity risk
“They showed in one study that if you have even five friends on the internet, just internet, Proximity, not in real person who are struggling with obesity, your chances of becoming obese are exponentially higher.”
Codie Sanchez: Achieving fitness and wealth requires setting strict peer boundaries
“If you want to get fit, if you want to get financially free, you have to be okay setting boundaries for other people to stay out of if they are not going to help you progress because we are just not strong enough as individual willpowered beings to have willpo…”
Dr. Moore: Some product launches make $1M while others completely fail
“I'm over here, like, throwing shit at the wall, hoping it sticks, and sometimes it sticks, and I make a million dollars, and sometimes it doesn't stick, and it's just a, I just had a, like, an abysmal launch happen that did not convert, and I was like, I clear…”
Dr. Moore: Male testosterone rates and fertility are plummeting
“And then we've got abysmal fertility in men. We've got, you know, plummeting testosterone rates. So their swimmers are not swimming so well.”
Dr. Moore: IVF hormonal treatments damage metabolic health and reduce fertility
“That's the problem, is that hormonal load that these women go through is just wreaking havoc on their metabolic health, so they're becoming less and less and less It's fertile through the process of IVF.”
Dr. Moore: Doctors default to treatments tied to specialty and profits
“Because that's their hammer. And that hammer is profitable. It's their hammer, you know, like every, every doctor is going to have their hammer.”
Dr. Moore: South Korea passed the demographic point of no return
“I think in most countries in the world, the, what I have seen is that there's not even a population being born to replace the population. So we are at a certain point, there's a critical point where there's no return, and I think South Korea's definitely hit i…”
Dr. Moore: GLP-1s actively heal metabolic pathways beyond suppressing appetite
“They're not just working by decreasing your, you know, stomach motility. They're not just making you feel fuller longer. They're not just shutting down your appetite in your brain. They're not, that's not where it ends. They actually are healing metabolic path…”
Dr. Moore: Obesity is a standalone risk factor for multiple cancers
“Because obesity is a standalone risk factor for multiple types of cancer.”
Dr. Moore: Instagram banned me for sharing semaglutide COVID-19 data
“When I started talking about the data that I found from 20 21 on the protective mechanism of semaclutide against COVID, I got deplatformed at 232,000 off Instagram.”
Codie Sanchez: Never trust someone who refuses to criticize their own side
“I never really trust someone who hasn't pushed back against not only The other side, but their side. Because you have to be willing to do both in order to have, like, a reasonable rational debate.”
Dr. Moore: Big Pharma aggressively sent cease-and-desists to compounding pharmacies
“And they had sent a lot of Cease and desist letters to the telemedicine companies, the compounding pharmacists, the many doctors who were prescribing compounded, they really have, and Nova Nordisk And Eli Lilly have been pushing very hard against the compounde…”
Dr. Moore: Eli Lilly directly reported doctors' social media accounts
“And when she appealed. She was allowed to find out who reported her, and it was Eli Lilly, and it was the day after my account went down.”
Dr. Moore: Prozac was never studied as a long-term depression treatment
“Like Prozac for instance. It was never studied long term for depression. It was studied to be implemented as a basically like an emergency shoot when you're going through a terrible time period. You use it during a window.”
Dr. Moore: Do not take GLP-1s without lifting weights and eating protein
“I don't think that anybody even has the right to start a GLP-ONE if they also aren't going to the gym and lifting weights. And they're not also hitting their macros, their protein macros. So my argument from day one has been, it's not the peptides fault. It's …”
Dr. Moore: Untreated fatty liver becomes cirrhotic in 10 to 20 years
“Most doctors have fatty liver themselves. So they tell you, oh, your labs are normal. You have some fatty liver. That's okay. It's like, no, it's not okay. Your liver is literally going to be cirrhotic in 1020 years. Like this is maybe a little longer depends …”
Dr. Moore: Resistance training naturally drives improvements in diet and sleep
“Committing to that process because that process begets the other processes. So when you're training, you will automatically start to reprioritize what you put in your mouth because you work too hard in the gym to sacrifice and, you know, ruin the opportunity f…”
Dr. Moore: I used GLP-1s to address stress-induced weight gain
“Even with my best intentions at 50 years old, my metabolic health was starting to become compromised because of chronic stress. There's not, you know, there's not much I can do outside. I'm doing the gym. I'm doing the food. I'm doing all the things. And I was…”