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NO PRIORS Prediction Not checkable as stated
Fedus: Physical sciences and engineering will follow machine learning scaling laws
“And I think the physical sciences, physical engineering, Will have a very similar property where we establish these scaling properties and Bring that mindset.”
Liam Fedus Apr 3, 2026 ▶ 18:58 AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
NO PRIORS Prediction Not checkable as stated
Fedus: Self-improving software AI will not automatically generalize to domains like biology
“So rolling forward that software engineering self-improvement, I think you're going to have a system that can write complete repositories, identify bugs, refactor code, But it doesn't suddenly understand biology. Right? It's just like there's a domain gap ther…”
Liam Fedus Apr 3, 2026 ▶ 23:50 AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
NO PRIORS Prediction Not checkable as stated
Fedus: Recursive self-improvement is happening in software and entering AI research
“So, In that domain, I think it's happening now-ish. And I think we'll see the same thing too for AI research. That's a slower outer loop because now the experiment isn't just checking some unit tests passing, but it's checking what was the scaling property? Di…”
Liam Fedus Apr 3, 2026 ▶ 24:26 AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
NO PRIORS Assertion Not checkable as stated
Fedus: John Schulman steered OpenAI toward a general chatbot over narrow tools
“And we're all spitballing ideas, like writing bot coding bot. You know, very natural at the time. Some of our least interesting ideas were a meeting bot, so it would just sit in a Google Meet, take notes, and then send out, like, to-dos after. But John Schulma…”
Liam Fedus Apr 3, 2026 ▶ 4:34 AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
NO PRIORS Prediction Not checkable as stated
Fedus: AI Matter Synthesis Will Profoundly Impact Semiconductors, Aerospace, and Energy
“As you're pointing out, you're going from systems that aren't just writing essays, not just writing software, but to literally generating matter. And I think it has pretty profound implications to semiconductors, airspace, energy.”
Liam Fedus Apr 3, 2026 ▶ 16:18 AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
a16z Assertion Not checkable as stated
Fedus: Physics and chemistry demonstrate scaling laws similar to AI
“On the material science side, we're seeing scaling laws within physics, within chemistry both with respect to simulations, with respect to experiment, and it's like the same kind of principles at play and ML.”
Liam Fedus Sep 30, 2025 ▶ 3:02 Building an AI Physicist: ChatGPT Co-Creator’s Next Venture
NO PRIORS Assertion Not checkable as stated
Fedus: Compute costs outweigh physical infrastructure in materials AI labs
“What's interesting is just the compute costs relative to physical infrastructure is actually surprising where, you know, so much money is spent on the compute that the physical infrastructure sometimes is actually lower, but, you know, has very large lead time…”
Liam Fedus Apr 3, 2026 ▶ 20:03 AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
NO PRIORS Assertion Not checkable as stated
Fedus: Hybrid automated lab systems already produce large amounts of reliable data
“Already the reliability of the sort of like hybrid systems is sufficient to produce Huge amounts of reliable data”
Liam Fedus Apr 3, 2026 ▶ 26:41 AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
a16z Prediction Open · timeframe Sep 2028
Fedus: Periodic Labs will build AI co-pilots for space and defense
“Basically co-pilots for engineers, researchers in advanced industries. So maybe perhaps just being in Silicon Valley, we, you know, we really think about like computer oriented work. Everything is digital. Everything is bits, but there's so many industries. Li…”
Liam Fedus Sep 30, 2025 ▶ 27:32 Building an AI Physicist: ChatGPT Co-Creator’s Next Venture
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