AlphaFold, every mention

Nobel Laureate John Jumper: AI is Revolutionizing Scientific Discovery · Y Combinator Jul 15, 2025 · 20 mentions

• ▶ 3:54 John Jumper That, ultimately, we are building tools that will enable scientists to make discoveries, and what I think is really heartening about the work we've done and the part that really, I think, still just resonates with me at my core is there…
• ▶ 10:51 John Jumper We want to put something in the middle and then alpha fold, and we want to end up with something on the right.
• ▶ 13:29 John Jumper So someone, AlphaFold II is the system that is quite famous, the one that, ah, was quite a large improvement. 3 times in the scene
• ▶ 13:34 John Jumper AlphaFold I was the best in the world. 2 times in the scene
• ▶ 15:27 John Jumper Alpha-fold is an equivariant system, and it's great. 2 times in the scene
• ▶ 15:48 John Jumper Alpha fold itself on this GDT scale that you can see on the left graph, alpha fold two was about 30 GDT better than alpha fold one, and equivariance explains two or three of this.
• ▶ 15:48 John Jumper Alpha fold itself on this GDT scale that you can see on the left graph, alpha fold two was about 30 GDT better than alpha fold one, and equivariance explains two or three of this.
• ▶ 20:09 John Jumper You know, this morning I got an alpha fold prediction, and now it's much better. 2 times in the scene
• ▶ 20:48 John Jumper In fact, there was a special issue of science on the nuclear pore complex a few months after the tool came out, and the special issue was all about this particular very large kind of several hundred protein system, and three out of the… 6 times in the scene
• ▶ 26:42 John Jumper And I think this is really where we see the foundational model aspect of alpha fold or other narrow systems.