Xaira Therapeutics

“This is also why we incorporate PPI networks as the prior knowledge into our model. And although the model right now are trained on single gene perturbations, but once the model is trained, you can actually predict combinatorial perturbations just on the model…”

“So effectively we differentiate iPSC into 10 different cell types in one single experiment without restriction. And we did a genome scale perturbation across them. So you can imagine instead of just generating 10,000 different biological experiments, We did 10…”

“One of the rewarding signals I receive after we develop Excel is that like it's a wow moment from biologists that this is the first time biologists actually find the model can predict exactly how these unseen cell lines kind of respond to different perturbatio…”

“There are three main AI platforms that we're building here. The first one is Protein Design, work that spun out of our co-founder Dr. David Baker's group from UW. A lot of the current generation of protein designers are here in the company. So there, the think…”

“Critically, Excel has not seen active cell T cells. And it's able to make accurate prediction, not only on the known biology, the TCR complex, predicting their effect accurately, that these are going to inactive the T cells, which It's exactly what we would ex…”

“However, definitely our ongoing work and the next version of Excel will be able to infer the spatially aware representations for different cells.”

“When we started data generation, so we put out the method that I talked about, as well as the first two datasets, which is the world's largest perturbsic data released at the time. Last June in the preprint, we call it dataset XLS Orion.”

“X-Cell is Xera's first virtual cell models. It is an AI model that can predict the response to genetic perturbations. Certainly we can extend it to other type of interventions such as drug perturbations chemical perturbations, et cetera.”