structure prediction

“Folding is the more complex process of actually understanding, like, how it goes from, like, this disordered state into, like, a structured, like, state, and that I don't think we've made that much progress on, but the idea of, like, yeah, going straight to th…”

“What's going to happen in a regression model is that, you know, I'm going to try to make an average of those different kind of answers that I had in mind. When you have a generative model, what you're going to do is, you know, sample all these different answer…”

“And in some cases it might actually be even easier to design a protein binder that is an antibody than to actually predict how it might bind that target in general.”

“The nice thing about structure prediction is there is a ground truth that you can compare against. For design, you, don't really have that. You're like, here's some new, like disease molecule. Give me a binder for that. And like, if you want to know if this th…”