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cryo-EM

3 statements across 2 episodes · 2 bullish · 0 bearish · 3 people on the record · first statement Jun 30, 2026 by Evan Feinberg · across every show →

Everything said about cryo-EM, oldest first

Jun 30, 2026 neutral
Assertion Supported
Feinberg: Solving experimental 3D protein structures takes months and tens of thousands
“Like you might as well solve the three D crystal structure or cryo-EM structure is what you're saying, which can cost tens of thousands of dollars. It can be months or years. Right. Entire PhD theses, postdocs can sometimes work literally 24 seven trying to so…”
Evan Feinberg Jun 30, 2026 ▶ 10:22 🔬 "The Most Innovative Diffusion Research Is Happening in Drug Discovery, Not Image Generation"
Aug 11, 2026 positive
Assertion Supported
Patil: Modern structure prediction models achieve sub-angstrom experimental accuracy
“We're getting the point now where these structure prediction models are within, you know, a few angstroms or less of the actual atomic positions that you validate.”
Neil Patil Aug 11, 2026 ▶ 34:37 🔬They Thought the Model Was Broken — Matt McPartlon & Neil Patil, Chai Discovery
Aug 11, 2026 positive
Assertion Supported
McPartlon: Chai-2 achieved 0.33 angstrom error in cryo-EM testing
“And in this case, it was a 0.33 angstrom error, which is one third the width of an atom.”
Matt McPartlon Aug 11, 2026 ▶ 34:45 🔬They Thought the Model Was Broken — Matt McPartlon & Neil Patil, Chai Discovery
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