AlphaFold 2, every mention

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every year anyone Matt McPartlon 5Gabriele Corso 5Jeremy Wohlwend 2

Verbatim, from the transcripts: the passages where AlphaFold 2 comes up

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🔬They Thought the Model Was Broken — Matt McPartlon & Neil Patil, Chai Discovery Aug 11, 2026 · 6 mentions

  • ▶ 2:15 Matt McPartlon So this is like alpha fold one days, um, and it was in the field during alpha fold two.
  • ▶ 6:07 Matt McPartlon Outfold one was like, and outfold two was like this huge breakthrough, but then like outfold two multimer came out like a year later.
  • ▶ 53:57 Matt McPartlon And like a lot of people think outfold to like solve structure prediction. 3 times in the scene
  • ▶ 1:09:47 unnamed speaker But the only way you can accomplish that is, I mean, the reason AlphaFold II and AlphaFold III worked, they were small models, relatively speaking, they were very compute intensive, but they were very data efficient.

🔬Generating Molecules, Not Just Models Feb 12, 2026 · 18 mentions

  • ▶ 1:07 unnamed speaker Uh, I guess we're maybe, what, six years post AlphaFold II right now, which was, like, kind of a big moment. 4 times in the scene
  • ▶ 6:45 unnamed speaker Going back to the AlphaFold II moment, like, um, I remember this very well. 2 times in the scene
  • ▶ 15:40 Jeremy Wohlwend There's this nice line in the, um, I think it's in the AlphaFold II manuscript.
  • ▶ 21:33 unnamed speaker AlphaFold II came out and it was like, I think, fairly groundbreaking for this field. 3 times in the scene
  • ▶ 34:57 Gabriele Corso Um, now, you know, models like AlphaVault II and AlphaVault III are, you know, still very large models, but at the same time, 4 times in the scene
  • ▶ 38:44 unnamed speaker Yeah, so you, you know, uh, AlphaFold II, really cool. 2 times in the scene
  • ▶ 47:32 Gabriele Corso And so, you know, the example of, of, uh, doctrine was, you know, we, um, published this initial, uh, model called DiffDoc, um, in my first year of PhD, which was sort of like, you know, one of the early, um, models to try to predict, uh,…
  • ▶ 58:24 Jeremy Wohlwend I think like some of the interesting ones, like, I mean, we had, you know, this one individual who like wrote like a complex GPU kernel, you know, for part of the architecture, um, on, on a piece of, the funny thing is like that piece of…
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