The Ledger
Every statement that passed quotation and attribution checks. Mix any filter with any other: certainty 1/5, debate potential 5/5, or both at once.
why aren't all 13 resolved? a statement only gets an assessment when the public record can support or contradict it. opinions and what-ifs never can, and 0 checkable ones are still open, waiting for their date. predictions held up or didn't; assertions are supported or contradicted. on every card: ▮▮▮▮▮ certainty · ▮▮▮▮▮ debate potential. speakers are clickable
Sinclair: Research shows cellular epigenetic aging damage can be reversed
“And what we've discovered is that there are ways to, well, we discovered one of the main causes of scratches, that's broken chromosomes, which happens all the time in our bodies. Extreme cell damage also does that if we crush nerves. But we've also figured out…”
Sinclair: Data Shows Carnivore Diet Does Not Promote Long-Term Longevity
“I'm convinced and the data shows it from population studies that a carnivorous diet isn't a longevity producing diet in the long run, right?”
Sinclair: Sirtuin Gene Therapy Extends Mouse Lifespan in Lab Studies
“And there are seven of these epigenetic regulators, the things that prevent the scratches, and we can turn them on
With gene therapy.
In mice, we do this, and if you do it in the brain of a mouse, they'll live longer.
Do it in the body, they can live longer.”
Sinclair: One Gram of Daily NMN Raises Blood NAD Levels
“And I know from clinical trials that I've been involved with that taking a gram of NMN, which I do every day, raises NAD levels in whole blood, in the cells in the blood, probably in the rest of my body as well.”
Sinclair: Combining exercise and NMN doubled running endurance in mice
“In the animal studies in my lab, when we gave NMN, this molecule that I take every day, to a mouse that was sedentary, didn't have a wheel, didn't run, it could run further, ok?
And we actually have human data that's looking really promising in that direction …”
Sinclair: Research Restored Eyesight and Reversed Aging in Mice
“About a year ago, we published that we could reverse the age of an animal. And we restored eyesight to a blind old mouse and cure glaucoma in that animal.”
Sinclair: 100,000 People Die Worldwide Every Day From Aging-Related Causes
“Every day over a 100,000 people die from aging itself”
Sinclair: Sirtuin Gene Therapy Extends Lifespan in Mice
“In mice, we do this, and if you do it in the brain of a mouse, they'll live longer. Do it in the body. They can live longer, but we can't genetically modify ourselves.”
Sinclair: Hunger Cravings Subside After Three Weeks of Fasting
“Now, if you start fasting, and you've never done it before, you will feel hungry. There's a hormone called ghrelin, which will cause that. Of course, it's not real. Hunger is just mental state, but after three weeks, you find, I found, that the state of hunger…”
Sinclair: Having a reliable partner is among the top drivers of longevity
“It's been shown by studying hundreds of people over their lifetimes that one of the most important, if not the most important factor, is to have a reliable partner. A pet can substitute for that if you don't have one of those at the time. But yeah, you want co…”
Sinclair: High Lp(a) affects ~30% of people and reduces lifespan
“LP little a is the worst. You know, about 30% of us have this, and we're destined, if we don't do something, to have a short lifespan.”
Sinclair: Rapamycin extends animal lifespan even when started late in life
“There are animal studies you can, I could point to that show that you can have, affect this mTOR pathway with a drug called rapamycin that extends their lifespan, even if they're the equivalent of 70 years old.”
Sinclair: Finnish studies show sauna bathing dramatically protects heart health
“There's now a lot of evidence that being in a sauna is good for heart health at a minimum. There's a lot of studies of thousands of mostly men in Finland that do sauna bathing, as they call it. And they are protected dramatically, like they are exercising.”