Everything Juan Carlos Izpisua Belmonte said on any show that made the record, most notable first. Each card names its show and opens the statement there.
Belmonte: Metformin increases cognitive abilities and lifespan in monkeys
“For instance, I just finished, it's not, I think I can say that tomorrow, there will be just one of these molecules that diabetic people take, metformin, to lower down their glucose. They can reprogram the cells so that all the cognitive functions are not just…”
Belmonte: Epigenetic reprogramming rejuvenates mice without altering their underlying DNA
“Just by this small change in the chromatin, we can rejuvenate a mouse.”
Belmonte: Yamanaka factor pulses reverse diabetes symptoms in obese mutant mice
“If we just give a short pulse of these Yamanaka factors, we get this mouse. The mouse still keeps eating because it has the mutation. We haven't corrected. But the mouse now has less fat in the liver and can respond to glucose like a normal A young and healthy…”
Belmonte: Altos Labs has rejuvenated isolated human cells in vitro
“We have done this in isolated human cells in the petri dish, but the next step is to move to a human being, an entire organism like the mouse.”
Belmonte: Short Yamanaka factor pulses alter chromatin while preserving cell identity
“Rather than having the factors for a long time, we just gave a short pulse. What that is doing is altering the chromatin, but for a very short time, it's a small shock, and then the chromatin gets closed and maintains its identity.”
Belmonte: Exercise creates cellular gene expression changes similar to Yamanaka factor pulses
“We have compared what are the changes in the cell between exercise and the short pulses of Yamanaka factors. And you couldn't believe the similarities in the changes in gene expression that exercise does, and how overlap these changes happen when we do the Yam…”
Belmonte: Cellular reprogramming could translate from animal models to humans by 2034
“I feel the next decade, probably many of these discoveries with the caveat that it's a mouse, and a mouse is not a human, might be translated to human.”
Belmonte: Closed chromatin maintains cell youth while open chromatin causes aging
“When the epigenome, when the chromatin is closed, we call this heterochromatin, the cell is young, is healthy. When the chromatin is open, it leads to the increase, the loss of buffer capacity, and therefore, disease and aging.”
Belmonte: Inherited genetic mutations account for under 1% of human diseases
“Precision medicine, by which we can Fix some of these mutations, errors that our parents transmit into the book of our life. But that's less than one percent of the diseases.”
Belmonte: Age becomes the major disease risk factor after age 40 to 45
“After a certain number of years, around 40, 45, the major risk factor for getting any disease is precisely that, years, age.”
Belmonte: Age-related diseases emerge when cellular buffer capacity declines
“During normal aging, there is more stress. And the buffering capacity, the resilience of these cells goes down. And when these two arrows, these two curves, Mix. Disease appear.”
Juan Carlos Izpisua Belmonte
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