Dr. Nicole Paulk
CEO & Founder, Siren Biotechnology. On 1 show, 1 appearance. The Shows tab opens the full record on each.
founderexecutivescientistacademic@Nicole_Paulk ↗LinkedIn ↗sirenbiotechnology.com ↗
Dr. Nicole Paulk is a pioneer in adeno-associated virus (AAV) gene therapy who previously led an academic laboratory as a professor at UCSF. She founded Siren Biotechnology to develop universal AAV immuno-gene therapies designed to treat solid tumors and severe genetic conditions.
1shows
1appearances
18statements
11resolved
4supported
3contradicted
36%fully supported
Everything Dr. Nicole Paulk said on any show that made the record, most notable first. Each card names its show and opens the statement there.
Dr. Nicole Paulk: Viral gene therapy can completely cure inherited genetic blindness
“So we're able to completely cure blindness.”
Prediction: Every person alive today will eventually receive viral gene therapy
“I promise you, in your lifetime, no matter how old any of you are in this audience, in your lifetime you are going to receive a viral gene therapy as medicine.”
Anti-aging rejuvenation gene therapies are likely five to ten years away
“We're probably five to 10 years out on being ready to do this, but this is absolutely coming in your lifetime. You could get a rejuvenation gene therapy.”
FDA blocks clinical trials for lifestyle gene therapies like aging or sleep
“The FDA only lets you queue up clinical trials to test drugs that are for diseases, but aging is not a disease state. Wanting to sleep fewer hours is not a disease state. Insomnia is, but wanting to just sleep fewer hours and be fully rested is not a disease s…”
Catalent Pharma has a 2.5-year waitlist for 5,000-liter viral bioreactors
“But viruses are still something, like, if I queue up the biggest CDMO in the world, Catalent Pharma and ask them to make us a 5000 liter bioreactor virus, they'll absolutely say yes, but they won't even touch it for two and a half years.”
Dr. Nicole Paulk: Giving humans biological night vision is scientifically possible today
“Oh, night vision is totally possible.”
Dr. Nicole Paulk: Every human develops single-cell tumors every single day
“Every single one of you in this audience has a tumor. You've had a tumor every single day of your life. It's usually a single cell. You often have many of them throughout your body.”
Siren Biotechnology's viral gene therapy effectively cured mice of brain cancer
“So we can massively improve the lifespans of these animals, and for all intents and purposes, cure these mice, ah, of brain cancer”
Siren Biotechnology plans human trials for brain cancer gene therapy in 2025
“And we're queuing up for a clinical trial in twenty-twenty-five. So we're excited to start our clinical trial in twenty-twenty-five”
Siren Biotech faces 18 months of paperwork before Phase I cancer trials
“We could start our brain cancer clinical trial today, but we're looking at 18 months of paperwork in order to file to do that first phase one”
Dr. Nicole Paulk: 80% of protein-coding genes fit inside AAV viral vectors
“Of all protein coding genes, 80% of those genes can fit within my virus.”
Viral gene therapies can now treat more than single-gene disorders
“So historically, we have used these to treat single gene genetic disorders, but we can use these much more broadly now, and I'll share a little bit about that.”
Dr. Nicole Paulk: The vast majority of viruses do not sicken humans
“The vast majority of viruses on the planet are very good at getting inside of you, but very few of them make you sick.”
Traditional gene therapies take 10-15 years and up to $3B to develop
“So every gene therapy on the planet, all the ones on that bullseye I just showed you on the last slide, whether they're from academia, industry, big pharma, doesn't matter. Every one of those is bespoke and personalized for a single indication, so that virus t…”
Humira generated $21B annually as the most successful drug in 20 years
“This antibody sells on average a little over twenty one billion dollars worth of just that drug every single year and has been the most successful drug for the last 20 years.”
DEC2 gene mutation allows some to feel rested on four hours' sleep
“These patients, again, single mutation, single gene, these patients only need four hours of sleep a night to be completely rested the same way that we have, ah, the need for eight to nine hours of sleep a night.”
One line per show, most statements first. The link opens Dr.'s full record on that show: the calibration, argument clarity, speaking style and every statement made there.
| Show | Role there | Eps | Statements | Record | |
|---|---|---|---|---|---|
 ALL-INLEDGER | CEO & Founder, Siren Biotechnology | 1 | 18 | 36% 4/11 | full record on All-In → |