Everything Dr. Jim said on any show that made the record, most notable first. Each card names its show and opens the statement there.
Not all arterial plaque is bad: stable plaque actually protects you
“We learned that not all plaque is bad. In fact, that some plaques are extremely dangerous for you and the strongest predictors of who will have a heart attack and others are actually Very stable and almost protected against having a heart attack in the future.”
The first symptom of heart disease is often a catastrophic event
“The most common presentation for having heart disease like that is not presenting with chest pain or shortness of breath, but it's simply having a catastrophic event, dying of a heart attack or suffering a heart attack at home with no antecedent warning.”
90% of heart attacks are preventable with existing medical treatments
“90% of heart attacks are preventable. We, it's not that we lack the treatments. It's that we're just not identifying people soon enough so that we can prevent these events from happening.”
Heart medications don't eliminate plaque; they transform it into stable protective plaque
“And what we found was that the medicines, they didn't make plaque go away per se. They just transformed that plaque from the good to the, from the bad to the good plaque over time, and that was the mechanism of stabilization.”
Cleerly is running a 7,500-patient RCT on asymptomatic screening
“We're doing a large-scale randomized control trial right now. It's about 7500 patients. We're a little over 2000 patients enrolled, and the purpose of this trial is to test the hypothesis that image-guided care, clearly guided care, is superior to conventional…”
Cleerly's massive clinical trial costs well over $200 million
“Like, if you include the in-kind support, like, it's well over two hundred million dollars to do this trial.”
Heart disease kills 40% more people than all cancers combined
“Heart attacks are the number one cause of death. They're the number one cause of death in men and women. Cardiovascular disease deaths are the number one cause of death and total 40% more deaths than all cancers combined.”
Arterial plaque buildup integrates a lifetime of heart disease risk factors
“When something has too many factors that are contributing to the disease, I think that the best way to do it is to find a single metric that integrates the lifetime exposure of That, to that, of that individual, to all of those known and unknown risk factors, …”
Min: CT scans are the only current tool to visualize soft arterial plaque
“In this particular case, the only technology that's available today that allows you to look at that really bad plaque, which is the very cholesterol fatty filled plaques that are building up silently in the walls of patient's arteries is the CT scan today.”
Getting reimbursement for a digital health product takes 10 to 15 years
“And so then you go through this effort and this is probably, I've just described the 10 to 15 year effort here to get to that point.”
Medical practice takes 20 years to change because doctors must retire first
“And so it's just, and then they always say in medicine that things take about 20 years to change medicine. And if you think about it, that is about the time that it takes for one generation to retire and a new generation to come about. So, you know, once peopl…”
Over 50% of heart attack victims are completely asymptomatic beforehand
“Oh, well over 50%.”
Min: Cleerly raised $225M Series C from Fidelity and T. Rowe Price
“So the Series C round came together with Fidelity and T. Rowe Price.
Pablo Srugo: How much was that?
Dr. Jim: that was about two hundred twenty-five million.”
Cleerly was 17 days away from running out of cash during COVID-19
“I mean, during the pandemic, right, like, we were 17 days away from being out of operating capital.”
Dr. Min: A heart attack occurs every 40 seconds in the US
“In the U.S., there'll be somebody who suffers a heart attack every 40 seconds.”
Manual coronary plaque tracing previously took 8 to 10 hours per scan
“We hired 20 technologists, CT technologists who had gone to radiographic imaging school, and they were the ones who were tracing out all of the images so that we could quantify and characterize the amount and the type of plaque that there was. It was taking th…”
Min: Cleerly's AI has been validated against invasive catheter benchmarks
“There's, you know, a number of studies that we've done as a company that have validated our technologies against every invasive catheter that you could think of to prove that, like, what we're seeing is actually the disease that the interventional or the invas…”
Dr. Jim: There are 1,100 health insurance payers in the US
“There's 1100 payers in the country, so then you've got to go talk to them each one by one.”
Dr. Jim Min: 15–20M Americans present yearly with heart disease symptoms
“It's about somewhere between 15 and twenty million people in the US every year who present like that.”
Cleerly has grown over 100% annually for the past five years
“Yeah, I mean, we've done a blended, a compounded annual growth of about a little over a hundred percent over the last five years, and so we've been doubling, more than doubling every year, which is great.”
Dr. Min: Cleerly has served close to 100,000 total patients
“I think, I forget exactly how many patients we've done in total, but it's probably got to be close to a 100,000 at this point in time, so somewhere in that range or so.”
Dr. Jim Min: Historically, arterial plaque could only be detected invasively
“Historically, we could only see it through invasive tests, so you'd have to stick a wire or a catheter down somebody's heart artery.”